Hybrid Organic-Inorganic Composite Materials for Bone Repairs

描述（由申请人提供）：生物玻璃和生物陶瓷已在骨修复中获得临床应用。但是，由于其脆性和较差的机械性能，其应用通常限于非承载条件。通过剪切混合生物活性无机相（玻璃、陶瓷或羟基磷灰石）与高机械性能生物相容性有机聚合物相制备的聚合物复合材料由于与天然骨相似而引起了人们的强烈兴趣，所述天然骨是磷灰石和胶原基质的复合材料。合成复合材料中有机聚合物相与无机磷灰石或玻璃相之间的界面结合差通常导致在用作骨组织工程支架的应用中，特别是在承载条件下，应力传递能力较低。为了实现高应力传递，需要两相的化学整合。这里提出的工作的具体目标是：1。通过溶胶-凝胶技术制备了无机玻璃（CaO-SiO 2-ZnO）与各种有机相结合的三维大孔杂化材料：a.生物相容性有机聚合物，聚（富马酸丙二醇酯）和聚（三甲氧基硅基）丙基甲基丙烯酸酯（PTPMA）-与玻璃化学结合。B.通过溶胶-凝胶处理与玻璃结合的硅烷官能化的碳纳米管。c.使用水热技术使纳米磷灰石在侧壁官能化的碳纳米管（-COO-、HO-和膦酸基团）上成核。这些制备的复合材料有望显示出优异的骨结合能力，具有改善的机械性能，从而找到应用，特别是作为骨组织工程的支架。我们还将开发成分-性能关系，为预测制造变量（有机：无机基质的比例、孔隙率、聚合物类型和聚合物与共聚物的比例）如何影响生物活性（骨结合能力）提供指导，与散装骨相比，以及与天然骨相比的机械性能。将使用模拟体液和人胎儿成骨细胞进行生物活性研究。拟议工作的另一个目的是汇集互补的专业知识，以支持在PVAMU强大的生物医学研究，特别是，提高研究生产力和各自的研究人员的奖学金。这项研究将制造具有良好的骨结合能力和改善的机械性能的混合复合材料，而没有与使用自体移植物和同种异体移植物修复有缺陷或患病的骨相关的问题。该项目涉及合成复合材料的制造，可用于骨修复或骨疾病的治疗。这些轻质复合材料具有生物相容性，能够刺激体液中的骨矿物质形成。

DESCRIPTION (provided by applicant): Bioglass and Bioceramics have found clinical applications in bone repairs. However, because of their brittleness and poor mechanical properties, their applications are generally limited to non load bearing conditions. Polymer composites fabricated by shear mixing of bioactive inorganic phase (bioglass, ceramics, or hydroxyl apatite) with high mechanical performance biocompatible organic polymer phase are eliciting strong interest because of the similarity with natural bone, a composite of apatite and collagen matrix. The poor interfacial bonding between the organic polymer phase and the inorganic apatite or bioglass phase in synthetic composites generally give rise to lower stress transfer ability in applications as scaffolds for bone tissue engineering especially under load bearing condition. To achieve high stress transfer, chemical integration of the two phases would be required. The specific aims of the work proposed here are: 1. To fabricate by sol-gel techniques 3-D macroporous hybrid materials incorporating inorganic bioglass (CaO-SiO2-ZnO) with a variety of organic phases: a.Biocompatible organic polymers , poly(propylene fumarate) and poly(trimethoxysilyl)propylmethacrylate (PTPMA)-chemically integrated with bioglass. b.Silane functionalized carbon nanotubes integrated with bioglass by sol-gel processing. c.Nucleation of nano-apatite on side wall functionalized carbon nanotubes (-COO-, HO- and phosphonic acid groups) using hydrothermal technique. These fabricated composites are expected to show excellent bone bondind ability arising from bioglass with improved mechanical properties and thus find application, especially as scaffolds in bone tissue engineering. We shall also develop composition-property relationship to provide guidance for predicting how fabrication variables, (ratio of organic : inorganic matrix, porosity, type of polymer and polymer to co-polymer ratio) affect bioactivity (bone bonding ability) when compared to bulk bioglasses and mechanical properties compared to natural bone. The bioactivity will be conducted using simulated body fluid and cell studies using human fetal osteoblastic cells. Another aim of the proposed work is to bring together complementary expertise to support strong biomedical research at PVAMU and specifically, enhance research productivity and scholarship of respective investigators. This proposed study will fabricate hybrid composites materials with excellent bone bonding ability and improved mechanical properties without the problems associated with the use of autografts and allografts in repairing defective or diseased bone This project involves the fabrication of synthetic composite materials that can be utilized in bone repair or treatment of bone diseases. These lightweight composites are biocompatible and are able to stimulate bone mineral formation in body fluid.