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Sol-Gel Synthesis of bioactive glass materials

生物活性玻璃材料的溶胶-凝胶合成

基本信息

批准号：
6813781
负责人：
ADEREMI R OKI
金额：
$ 13.67万
依托单位：
PRAIRIE VIEW AGRI & MECH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-01 至 2007-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6813781
关键词：
biomaterial development /preparation bone prosthesis bone regeneration cell differentiation cell proliferation gel glass manganese osteoblasts physical state tissue /cell culture tissue support frame zinc

项目摘要

DESCRIPTION (provided by applicant): The limitations in the use of biologic grafts, has stimulated research effort in the search for biomaterials able to physically support bone growth (osteoconductive) and stimulate new bone growth (osteoinductive). The use of bioactive glass in repairing bone defect are well documented. The most widely studied Bioglass(R) is the 45S5 Bioglass(R), a four component (SiO2-Na20-CaO-P205) melt-derived bioactive glass that has been used in numerous medical and dental applications, and its biocompatibility and biodegradability well established. In this proposal, we present a new approach that make use of sol-gel processing to synthesize new bioglass incorporating zinc oxide, or manganese oxide (SiO2-CaO-P205-MO, M= Zn or Mn). Such bioglass are expected to have higher surface area and exhibit wider compositional range compared to the 45S5 Bioglass(R). They are also expected to exhibit enhance performance as promoter of osteoblast colonization, without the loss of major phenotypic characteristics, minimize the glass corrosion inherent in 45S5 Bioglass(R) by controlled generation of hydroxide ion and provide enough mechanical strength for in vivo applications. Our hypothesis is that modification of the chemical composition of the bioglass system by substitution of sodium oxide with zinc or manganese oxides at permissible concentration, will not induce material toxicity but rather might enhance the performance of the bioglass as bone materials. Zinc is an essential element in the growth of humans and other animals and is generally considered nontoxic. Bone growth retardation is a common finding in various conditions associated with zinc deficiency, suggesting a physiological role of zinc in the growth and mineralization of bone tissue. Zinc compound has also been shown to reveal a stimulatory effect on differentiation of osteoblastic cells.

描述（由申请人提供）：生物移植物使用的局限性刺激了研究工作，寻找能够物理支持骨生长（骨传导）和刺激新骨生长（骨诱导）的生物材料。生物活性玻璃在骨缺损修复中的应用已有大量文献报道。研究最广泛的生物玻璃是45S5生物玻璃，这是一种四组分（SiO2-Na2O-CaO-P2O5）熔融衍生的生物活性玻璃，已用于许多医疗和牙科应用，其生物相容性和生物降解性已得到充分证实。在本论文中，我们提出了一种新的方法，即利用溶胶-凝胶法合成含有氧化锌或氧化锰（SiO_2-CaO-P_（20）_5-MO，M = Zn或Mn）的新型微晶玻璃。与45S5 Bioglass（R）相比，预期这样的生物玻璃具有更高的表面积并且表现出更宽的组成范围。它们还有望表现出作为成骨细胞定植促进剂的增强性能，而不损失主要表型特征，通过控制氢氧离子的产生来最小化45S5 Bioglass（R）中固有的玻璃腐蚀，并为体内应用提供足够的机械强度。我们的假设是，通过在允许浓度下用锌或锰的氧化物取代氧化钠来修改骨玻璃系统的化学成分，不会诱导材料毒性，而是可能增强骨玻璃作为骨材料的性能。锌是人类和其他动物生长的必需元素，通常被认为无毒。骨生长迟缓是与缺锌相关的各种病症中的常见发现，表明锌在骨组织的生长和矿化中的生理作用。锌化合物也显示出对成骨细胞分化的刺激作用。