Development and Evaluation of MRI Methods to Assess Diastolic Function

描述（由申请人提供）：拟议研究的广泛、长期目标是通过提供更好的方法来评估磁共振成像（MRI）研究的心脏功能，从而提高心力衰竭患者的护理能力。MRI是一种强大的医学成像方法，在心脏病患者的护理中发挥着越来越大的作用。然而，它仍然相对较少地应用于评价舒张期，即心动周期的舒张期，其可以在收缩期之前受到影响，收缩期是更常见的评价心动周期的收缩期。拟议研究的具体目的是：1）通过跟踪房室交界处的运动，进一步开发评价阿托洛尔的技术方法，2）在心力衰竭和舒张功能障碍患者样本和匹配的对照受试者中评价这些方法。如果成功，拟议的研究有可能提供一种改进的方法来评估舒张功能与MRI，这将是有用的照顾许多患者谁有或有风险发展为心力衰竭。 公共卫生相关性：舒张功能的评估是心力衰竭患者管理的重要组成部分，心力衰竭是一个主要的公共卫生问题。磁共振成像（MRI）在心脏成像中的作用越来越大，但其用于评估舒张功能仍然有限。该项目的总体目标是开发和初步评价使用MRI系统评价舒张功能的新方法;如果成功，这可能会提供一种改善心力衰竭患者管理的方法。

DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed research is to improve the ability to care for patients with heart failure, by providing better means to evaluate their heart function with magnetic resonance imaging (MRI) studies. MRI is a powerful medical imaging method, with a growing role in the care of heart patients. However, it has still been relatively little applied to the evaluation of diastole, the relaxation phase of the cardiac cycle, which can be affected before systole, the more commonly evaluated contraction phase of the cardiac cycle. The Specific Aims of the proposed research are to: 1) further develop technical methods for evaluation of diastole through tracking the motion of the atrioventricular junction, and 2) evaluate these methods in a sample of patients with heart failure and diastolic dysfunction and in matched control subjects. If successful, the proposed research has the potential to provide an improved means to assess diastolic function with MRI, which would be useful in caring for many patients who have or are at risk for developing heart failure. PUBLIC HEALTH RELEVANCE: Assessment of diastolic function is an important part of the management of patients with heart failure, a major public health problem. Magnetic resonance imaging (MRI) has had a growing role in cardiac imaging, but its use for assessing diastolic function is still limited. The overall aim of this project is the development and initial evaluation of new methods for evaluating diastolic function with MRI systems; if successful, this could provide a way to improve the management of heart failure patients.