Development and Evaluation of MRI Methods to Assess Diastolic Function

描述（由申请人提供）：拟议研究的广泛，长期目标是通过磁共振成像（MRI）研究提供更好的方法来评估心力衰竭患者的心脏功能，从而提高对心力衰竭患者的护理能力。核磁共振成像是一种强大的医学成像方法，在心脏病患者的护理中发挥着越来越大的作用。然而，它仍然相对较少应用于评估舒张期，心脏周期的松弛期，它可以在收缩期之前受到影响，更常见的评估心脏周期的收缩期。本研究的具体目的是：1)进一步发展通过跟踪房室连接运动来评估舒张期的技术方法，2)在心力衰竭和舒张功能不全的患者样本和匹配的对照组中评估这些方法。如果成功，这项研究有可能提供一种改进的MRI舒张功能评估方法，这将有助于照顾许多已经或有发展为心力衰竭风险的患者。

DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed research is to improve the ability to care for patients with heart failure, by providing better means to evaluate their heart function with magnetic resonance imaging (MRI) studies. MRI is a powerful medical imaging method, with a growing role in the care of heart patients. However, it has still been relatively little applied to the evaluation of diastole, the relaxation phase of the cardiac cycle, which can be affected before systole, the more commonly evaluated contraction phase of the cardiac cycle. The Specific Aims of the proposed research are to: 1) further develop technical methods for evaluation of diastole through tracking the motion of the atrioventricular junction, and 2) evaluate these methods in a sample of patients with heart failure and diastolic dysfunction and in matched control subjects. If successful, the proposed research has the potential to provide an improved means to assess diastolic function with MRI, which would be useful in caring for many patients who have or are at risk for developing heart failure. PUBLIC HEALTH RELEVANCE: Assessment of diastolic function is an important part of the management of patients with heart failure, a major public health problem. Magnetic resonance imaging (MRI) has had a growing role in cardiac imaging, but its use for assessing diastolic function is still limited. The overall aim of this project is the development and initial evaluation of new methods for evaluating diastolic function with MRI systems; if successful, this could provide a way to improve the management of heart failure patients.