Development and Evaluation of MRI Methods to Assess Diastolic Function

描述(由申请人提供)：拟议研究的广泛、长期目标是通过提供更好的方法来利用磁共振成像(MRI)研究评估心力衰竭患者的心功能，从而提高护理心力衰竭患者的能力。核磁共振是一种强大的医学成像方法，在心脏病患者的护理中发挥着越来越大的作用。然而，它在评价舒张期和舒张期方面的应用相对较少，舒张期是心动周期的松弛阶段，在收缩之前会受到影响，而收缩是更常见的评价心动周期的收缩阶段。这项研究的具体目的是：1)进一步开发通过跟踪房室交界处的运动来评估舒张期的技术方法，以及2)在心力衰竭和舒张期功能障碍的患者样本和匹配的对照组受试者中评估这些方法。如果成功，这项拟议的研究有可能提供一种改进的手段，通过核磁共振来评估舒张期功能，这将有助于护理许多患有或有发展为心力衰竭风险的患者。 公共卫生相关性：评估舒张期功能是心力衰竭患者管理的重要组成部分，心力衰竭是一个主要的公共健康问题。磁共振成像(MRI)在心脏成像中的作用越来越大，但它在评估舒张期功能方面的应用仍然有限。这个项目的总体目标是开发和初步评估使用MRI系统评估舒张期功能的新方法；如果成功，这将为改善心力衰竭患者的管理提供一种方法。

DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed research is to improve the ability to care for patients with heart failure, by providing better means to evaluate their heart function with magnetic resonance imaging (MRI) studies. MRI is a powerful medical imaging method, with a growing role in the care of heart patients. However, it has still been relatively little applied to the evaluation of diastole, the relaxation phase of the cardiac cycle, which can be affected before systole, the more commonly evaluated contraction phase of the cardiac cycle. The Specific Aims of the proposed research are to: 1) further develop technical methods for evaluation of diastole through tracking the motion of the atrioventricular junction, and 2) evaluate these methods in a sample of patients with heart failure and diastolic dysfunction and in matched control subjects. If successful, the proposed research has the potential to provide an improved means to assess diastolic function with MRI, which would be useful in caring for many patients who have or are at risk for developing heart failure. PUBLIC HEALTH RELEVANCE: Assessment of diastolic function is an important part of the management of patients with heart failure, a major public health problem. Magnetic resonance imaging (MRI) has had a growing role in cardiac imaging, but its use for assessing diastolic function is still limited. The overall aim of this project is the development and initial evaluation of new methods for evaluating diastolic function with MRI systems; if successful, this could provide a way to improve the management of heart failure patients.