Development and Evaluation of MRI Methods to Assess Diastolic Function

评估舒张功能的 MRI 方法的开发和评估

• 批准号: 8290310
• 负责人: Leon Axel
• 金额: $ 25.35万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8290310
• 关键词: Affect; Asses; Cardiac; Caring; Clinical; Data; Development; Diagnosis; Diastole; Diastolic heart failure; EFRAC; Effectiveness; Etiology; Evaluation; Functional disorder; Heart; Heart Diseases; Heart failure; Image; Image Analysis; Investigation; Location; Magnetic Resonance Imaging; Measurement; Measures; Medical Imaging; Methods; Morbidity - disease rate; Motion; Myocardial; Myocardium; Normal Range; Patient Care; Patients; Phase; Public Health; Reference Standards; Relaxation; Reporting; Research; Risk; Role; Sampling; Severities; Source; Symptoms; System; Systole; Western World; base; design; disability; functional disability; heart function; imaging modality; improved; mortality; novel; research clinical testing; response; tool

DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed research is to improve the ability to care for patients with heart failure, by providing better means to evaluate their heart function with magnetic resonance imaging (MRI) studies. MRI is a powerful medical imaging method, with a growing role in the care of heart patients. However, it has still been relatively little applied to the evaluation of diastole, the relaxation phase of the cardiac cycle, which can be affected before systole, the more commonly evaluated contraction phase of the cardiac cycle. The Specific Aims of the proposed research are to: 1) further develop technical methods for evaluation of diastole through tracking the motion of the atrioventricular junction, and 2) evaluate these methods in a sample of patients with heart failure and diastolic dysfunction and in matched control subjects. If successful, the proposed research has the potential to provide an improved means to assess diastolic function with MRI, which would be useful in caring for many patients who have or are at risk for developing heart failure.

描述（由申请人提供）：拟议研究的广泛、长期目标是通过提供更好的方法来评估磁共振成像（MRI）研究的心脏功能，从而提高心力衰竭患者的护理能力。MRI是一种强大的医学成像方法，在心脏病患者的护理中发挥着越来越大的作用。然而，它仍然相对较少地应用于评价舒张期，即心动周期的舒张期，其可以在收缩期之前受到影响，收缩期是更常见的评价心动周期的收缩期。拟议研究的具体目的是：1）通过跟踪房室交界处的运动，进一步开发评价阿托洛尔的技术方法，2）在心力衰竭和舒张功能障碍患者样本和匹配的对照受试者中评价这些方法。如果成功，拟议的研究有可能提供一种改进的方法来评估舒张功能与MRI，这将是有用的照顾许多患者谁有或有风险发展为心力衰竭。

项目成果

Evaluation of diastolic function by three-dimensional volume tracking of the mitral annulus with cardiovascular magnetic resonance: comparison with tissue Doppler imaging.

• DOI: 10.1186/s12968-014-0071-3
• 发表时间: 2014-09-20
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Wu V;Chyou JY;Chung S;Bhagavatula S;Axel L
• 通讯作者: Axel L