DEVELOPMENT OF A NEW MRI METHOD TO STUDY CARDIAC MOTION

心脏的良好运动是非常有临床意义的，而且有许多不同的 人们用各种技术来研究它，但都有很大的局限性。 和/或风险。该项目的目标是开发一种新的、非侵入性的、 利用磁共振研究心脏运动的方法 成像(MRI)，与以前相比，它具有显著的优势 可用的方法。这个应用程序的具体目标是专注于 这种方法的技术方面：1)开发方法本身，2) 分析其所能产生的数据的开发手段；3)开发手段 用于显示该分析的结果和4)验证结果。 我们还将使用这一技术来获得关于正常收缩的数据 心。更广泛、更长期的目标是将这种新方法用作 在心脏生理学研究方面的进一步研究的代价 以及心脏疾病影响的临床研究，如心肌梗死 心肌梗死、缺血和心肌病，心脏运动， 最终目标是提高我们诊断心脏病和 监督它的治疗。 产生磁性标记图案的基本技术 心肌中可用于非侵入性跟随心脏的条纹 通过心脏周期的室壁运动，已经在 初步表格。对该技术的进一步改进和扩展 将被开发，以提高其灵活性和临床易用性 申请。一种定量、高效地分析环境污染的方法 可以产生的大量数据将需要在 为了充分利用心脏方面的新信息 这项技术可以实现的动议。有效的手段 显示结果也将需要开发，以便使它们 随处可见。通过对比验证这些结果 对心壁运动进行同步独立测量 标准侵入性技术(植入脉冲传输的声学显微测量 也将进行压电晶体)，以评估 这种新方法的精确度。最后，我们将能够使用这个 技术，以获得更好的关于正常收缩模式的数据 人的左心室比目前常规的 技巧。

Heart well motion is of great clinical interest, and many different techniques have been employed to study it, all with significant limitations and/or risks. The goal of this project is to develop a new, noninvasive, methods for studying the motion of the heart, using magnetic resonance imaging (MRI), which offers significant advantages relative to previously available methods. The specific aims of this application are to focus on the technical aspects of this method: 1) developing the method itself, 2) developing means for analyzing the data it can produce, 3) developing means for displaying the results of this analysis and 4) validating the results. We also will use this technique to obtain data on contraction of the normal heart. The broader, more long-term objectives are to use this new method as a toll for further research, both in investigations of cardiac physiology and in clinical studies of the effects of heart disease, such as myocardial infarction and ischemia and cardiomyopathies, on cardiac motion, The ultimate goal is to improve our abilities to diagnose heart disease and to monitor its therapy. The basic technique, which produces a pattern of magnetically tagged stripes in the myocardium that can be used to noninvasively follow heart wall motion through the cardiac cycle, has already been implemented in preliminary form. Further refinements and extensions of this technique will be developed in order to improve its flexibility and ease of clinical application. Methods for quantitatively and efficiently analyzing the large amounts of data that can be produced will need to be developed in order to take full advantage of the new kinds of information on cardiac motion that this technique can make available. Effective means for displaying the results will also need to be developed in order to make them readily accessible. Validation of these results by comparison with simultaneous independent measurements of heart wall motion performed with standard invasive techniques (sonomicrometry with implanted pulse-transit piezoelectric crystals) will also be carried out in order to assess the accuracy of this new method. Finally, we will be able to use this technique to obtain much better data on normal contraction patterns in the human left ventricle than is currently available from conventional techniques.