MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT)

描述（由申请人提供）：心力衰竭是一个主要的公共卫生问题，治疗选择有限。许多心力衰竭患者出现机械性不同步，并伴随心脏功能的进一步恶化。一些心力衰竭和不同步的患者受益于心脏起搏治疗（CRT），但三分之一或更多的心力衰竭患者选择接受常规标准的CRT治疗，未能从中获益。本项目的主要目标是：1）磁共振成像（MRI）的发展和评价和图像分析方法，以更好地预测使用心脏起搏治疗（CRT）治疗具有不同步性的心力衰竭的结果，以及2）使用成像导出的数据来计算机建模不同步性对心脏功能的影响及其对CRT的响应。由于心力衰竭是一种重要的临床疾病，并且目前用于预测CRT反应的方法准确性有限，因此该项目可能具有非常重要的临床意义。

DESCRIPTION (provided by applicant): Heart failure is a major public health problem, with limited treatment options. Many patients with heart failure develop mechanical dyssynchrony, with associated further deterioration in heart function. Some patients with heart failure and dyssynchrony benefit from cardiac resynchronization therapy (CRT), but a third or more of heart failure patients selected for treatment with CRT with conventional criteria fail to benefit significantly from it. The primary goals of this project are: 1) development and evaluation of magnetic resonance imaging (MRI) and image analysis methods to better predict outcome of the use of cardiac resynchronization therapy (CRT) for heart failure with dyssynchrony, and 2) use of the imaging-derived data for computer modeling of the effects of the dyssynchrony on cardiac function and its response to CRT. As heart failure is an important clinical condition, and as current means used to predict response to CRT have limited accuracy, this project is potentially clinically very significant.