MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT)

MRI 评估患者是否适合心脏再同步治疗 (CRT)

• 批准号: 8916207
• 负责人: Leon Axel
• 金额: $ 38.95万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8916207
• 关键词: Apical; Bundle-Branch Block; Cardiac; Cardiovascular system; Caring; Clinical; Computer Simulation; Data; Deterioration; Development; Devices; EFRAC; Echocardiography; Evaluation; Failure; Functional disorder; Future; Gadolinium; Goals; Health; Heart; Heart failure; Image; Image Analysis; Individual; Lateral; Left; Left ventricular structure; Location; Logistic Regressions; Magnetic Resonance Imaging; Mechanics; Methods; Modeling; Motion; Myocardial Contraction; Outcome; Patient Selection; Patients; Pattern; Performance; Procedures; Prospective Studies; Public Health; Regression Analysis; Relative (related person); Research; Role; Series; Severities; Symptoms; Testing; United States; Validation; Ventricular; Weight; aortic valve; base; conventional therapy; follow-up; functional disability; gadolinium oxide; heart function; implantation; improved; response

DESCRIPTION (provided by applicant): Heart failure is a major public health problem, with limited treatment options. Many patients with heart failure develop mechanical dyssynchrony, with associated further deterioration in heart function. Some patients with heart failure and dyssynchrony benefit from cardiac resynchronization therapy (CRT), but a third or more of heart failure patients selected for treatment with CRT with conventional criteria fail to benefit significantly from it. The primary goals of this project are: 1) development and evaluation of magnetic resonance imaging (MRI) and image analysis methods to better predict outcome of the use of cardiac resynchronization therapy (CRT) for heart failure with dyssynchrony, and 2) use of the imaging-derived data for computer modeling of the effects of the dyssynchrony on cardiac function and its response to CRT. As heart failure is an important clinical condition, and as current means used to predict response to CRT have limited accuracy, this project is potentially clinically very significant.

描述(由申请人提供)：心力衰竭是一个主要的公共卫生问题，治疗选择有限。许多心力衰竭患者出现机械不同步，并伴随着心功能的进一步恶化。一些患有心力衰竭和不同步的患者从心脏再同步治疗(CRT)中受益，但按照传统标准选择接受CRT治疗的心力衰竭患者中，有三分之一或更多的患者未能从CRT中显著受益。该项目的主要目标是：1)开发和评估磁共振成像(MRI)和图像分析方法，以更好地预测心脏再同步治疗(CRT)治疗不同步心力衰竭的结果，以及2)利用成像得出的数据，对不同步对心功能的影响及其对CRT的反应进行计算机模拟。由于心力衰竭是一种重要的临床疾病，而且目前用于预测CRT疗效的方法准确性有限，因此该项目具有潜在的临床意义。