Mechanisms of Alcohol Pathology: A Collaborative Partnership Between NCCU & UNC

酒精病理学机制：国立政治大学之间的合作伙伴关系

• 批准号: 7980361
• 负责人: Gregory Jay Cole
• 金额: $ 65.96万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7980361
• 关键词: Mechanisms; Alcohol; Pathology; Collaborative; Partnership

DESCRIPTION (provided by applicant): This is an application for a cooperative agreement (U54), "Mechanisms of Alcoholic Pathology" (MAP), between faculties of the Biomedical/Biotechnology Research Institute (BBRI) at North Carolina Central University (NCCU), a Minority-Serving Institution, and the Bowles Center for Alcohol Studies at The University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this CMARCD Program. Within this proposal, an NCCU Administrative component and three Research Components will integrate with the UNC-ARC Administrative, Education, 5 Research Components, and Cores, as well as other activities at the Bowles Center for Alcohol Studies. The UNC-ARC investigates mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that easily integrate into the ongoing overall theme of the UNC-ARC. Thus, both the UNC-ARC research components and this U54 proposal are integrated around the central theme that alcohol-induced pathology involves molecular and cellular changes that occur with alcohol abuse and alcoholism. The objectives of this U54 partnership are: 1) To investigate molecular mechanisms of alcohol-induced cellular pathology. By conducting an integrated and focused investigation into the molecular mechanisms of alcohol pathology this proposal will make important contributions to understanding alcohol morbidity and will create an active and successful research program on alcohol pathology at NCCU; 2) To provide scholarly education on Alcohol Pathology. The educational efforts in this proposal will educate NCCU students on alcohol pharmacology and alcohol related pathologies and health disparities through a combined Annual Alcohol Research Day, new alcohol course curricula developed by NCCU faculty, an alcohol seminar series hosted by the BBRI, the UNC Bowles Center for Alcohol Studies seminar series, and NCCU fellowships to students on alcohol pathology and minorities. Ultimately, this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an acfive and successful alcohol research program within the NCCU-BBRI that synergizes with the UNC-ARC to advance education and discoveries.

描述（由申请人提供）：这是一份合作协议（U54）申请，“酒精病理学机制”（MAP），是北卡罗莱纳中央大学（NCCU）生物医学/生物技术研究所（BBRI）、少数族裔服务机构和北卡罗莱纳大学（UNC）医学院鲍尔斯酒精研究中心之间的院系之间的申请。该提案代表了 NCCU 和 UNC 教员之间真正的合作努力，两个团体都做出了巨大的努力，对于该 CMARCD 计划的成功至关重要。在该提案中，NCCU 的一个行政部分和三个研究部分将与 UNC-ARC 行政、教育、5 个研究部分和核心以及鲍尔斯酒精研究中心的其他活动相整合。 UNC-ARC 研究酒精病理学的机制，涵盖酒精暴露引起的行为、组织和细胞病理学。该提案将重点关注易于融入 UNC-ARC 持续总体主题的细胞病理学。因此，UNC-ARC 研究组成部分和 U54 提案都围绕着一个中心主题进行整合，即酒精诱发的病理学涉及酒精滥用和酗酒时发生的分子和细胞变化。 U54 合作伙伴关系的目标是：1) 研究酒精诱导的细胞病理学的分子机制。通过对酒精病理学的分子机制进行综合和集中的研究，该提案将为了解酒精发病率做出重要贡献，并将在国立政治大学建立一个积极且成功的酒精病理学研究项目； 2) 提供酒精病理学的学术教育。该提案中的教育工作将通过年度酒精研究日、NCCU 教师开发的新酒精课程、由 BBRI 主办的酒精研讨会系列、北卡罗来纳大学鲍尔斯酒精研究中心研讨会系列以及 NCCU 为学生提供酒精病理学和少数族裔奖学金，对 NCCU 学生进行酒精药理学、酒精相关病理学和健康差异方面的教育。最终，该提案将开展、促进、支持和指导酒精病理学机制的研究，在 NCCU-BBRI 内创建一个积极且成功的酒精研究计划，与 UNC-ARC 协同推进教育和发现。