Mechanisms of Alcohol Pathology: A Collaborative Partnership Between NCCU & UNC

酒精病理学机制：国立政治大学之间的合作伙伴关系

• 批准号: 7980361
• 负责人: Gregory Jay Cole
• 金额: $ 65.96万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7980361
• 关键词: Mechanisms; Alcohol; Pathology; Collaborative; Partnership

DESCRIPTION (provided by applicant): This is an application for a cooperative agreement (U54), "Mechanisms of Alcoholic Pathology" (MAP), between faculties of the Biomedical/Biotechnology Research Institute (BBRI) at North Carolina Central University (NCCU), a Minority-Serving Institution, and the Bowles Center for Alcohol Studies at The University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this CMARCD Program. Within this proposal, an NCCU Administrative component and three Research Components will integrate with the UNC-ARC Administrative, Education, 5 Research Components, and Cores, as well as other activities at the Bowles Center for Alcohol Studies. The UNC-ARC investigates mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that easily integrate into the ongoing overall theme of the UNC-ARC. Thus, both the UNC-ARC research components and this U54 proposal are integrated around the central theme that alcohol-induced pathology involves molecular and cellular changes that occur with alcohol abuse and alcoholism. The objectives of this U54 partnership are: 1) To investigate molecular mechanisms of alcohol-induced cellular pathology. By conducting an integrated and focused investigation into the molecular mechanisms of alcohol pathology this proposal will make important contributions to understanding alcohol morbidity and will create an active and successful research program on alcohol pathology at NCCU; 2) To provide scholarly education on Alcohol Pathology. The educational efforts in this proposal will educate NCCU students on alcohol pharmacology and alcohol related pathologies and health disparities through a combined Annual Alcohol Research Day, new alcohol course curricula developed by NCCU faculty, an alcohol seminar series hosted by the BBRI, the UNC Bowles Center for Alcohol Studies seminar series, and NCCU fellowships to students on alcohol pathology and minorities. Ultimately, this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an acfive and successful alcohol research program within the NCCU-BBRI that synergizes with the UNC-ARC to advance education and discoveries.

描述（由申请人提供）：这是一份合作协议（U54），“酒精病理机制”（MAP），在北卡罗来纳中央大学（NCCU）的生物医学/生物技术研究所（bri），一个少数民族服务机构的院系和北卡罗来纳大学（UNC）医学院的鲍尔斯酒精研究中心之间的申请。该提案代表了北卡罗来纳大学和北卡罗来纳大学教师之间真正的合作努力，双方都为CMARCD项目的成功做出了重要贡献。在这项提案中，NCCU的行政组成部分和三个研究组成部分将与UNC-ARC的行政、教育、五个研究组成部分和核心以及鲍尔斯酒精研究中心的其他活动相结合。UNC-ARC研究酒精病理的机制，涉及酒精暴露引起的行为、组织和细胞病理。该提案将重点关注细胞病理学，这很容易融入UNC-ARC正在进行的总体主题。因此，UNC-ARC的研究组成部分和U54提案都围绕着酒精诱导的病理涉及酒精滥用和酒精中毒时发生的分子和细胞变化这一中心主题进行了整合。U54合作的目的是：1)研究酒精诱导细胞病理的分子机制。通过对酒精病理的分子机制进行综合和集中的调查，本提案将对了解酒精发病率做出重要贡献，并将在ncccu创建一个积极和成功的酒精病理研究项目；2)提供酒精病理学的学术教育。该提案的教育工作将通过年度酒精研究日、北卡罗来纳大学教师开发的新酒精课程、由英国酒精研究所主办的酒精系列研讨会、北卡罗来纳大学鲍尔斯酒精研究中心系列研讨会，以及北卡罗来纳大学酒精病理学和少数民族学生奖学金，向北卡罗来纳大学学生传授酒精药理学、酒精相关病理学和健康差异。最终，该提案将指导、促进、支持和指导酒精病理机制的研究，在nccu - bri内创建一个活跃而成功的酒精研究项目，与UNC-ARC协同推进教育和发现。