Mechanisms of Alcohol Pathology: A Collaborative Partnership Between NCCU & UNC

酒精病理学机制：国立政治大学之间的合作伙伴关系

• 批准号: 8702036
• 负责人: Gregory Jay Cole
• 金额: $ 86.07万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8702036
• 关键词: Alcohol abuse; Alcoholism; Alcohols; Behavioral; Biotechnology; Education; Educational Curriculum; Faculty; Fellowship; Investigation; Mentors; Minority; Minority-Serving Institution; Molecular; Morbidity - disease rate; North Carolina; Pathology; Research; Research Institute; Series; Students; Tissues; U-Series Cooperative Agreements; Universities; alcohol exposure; alcohol pharmacology; alcohol research; cellular pathology; health disparity; medical schools; problem drinker; programs; success; university student

DESCRIPTION (provided by applicant): This is an application for a cooperative agreement (U54), "Mechanisms of Alcoholic Pathology" (MAP), between faculties of the Biomedical/Biotechnology Research Institute (BBRI) at North Carolina Central University (NCCU), a Minority-Serving Institution, and the Bowles Center for Alcohol Studies at The University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this CMARCD Program. Within this proposal, an NCCU Administrative component and three Research Components will integrate with the UNC-ARC Administrative, Education, 5 Research Components, and Cores, as well as other activities at the Bowles Center for Alcohol Studies. The UNC-ARC investigates mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that easily integrate into the ongoing overall theme of the UNC-ARC. Thus, both the UNC-ARC research components and this U54 proposal are integrated around the central theme that alcohol-induced pathology involves molecular and cellular changes that occur with alcohol abuse and alcoholism. The objectives of this U54 partnership are: 1) To investigate molecular mechanisms of alcohol-induced cellular pathology. By conducting an integrated and focused investigation into the molecular mechanisms of alcohol pathology this proposal will make important contributions to understanding alcohol morbidity and will create an active and successful research program on alcohol pathology at NCCU; 2) To provide scholarly education on Alcohol Pathology. The educational efforts in this proposal will educate NCCU students on alcohol pharmacology and alcohol related pathologies and health disparities through a combined Annual Alcohol Research Day, new alcohol course curricula developed by NCCU faculty, an alcohol seminar series hosted by the BBRI, the UNC Bowles Center for Alcohol Studies seminar series, and NCCU fellowships to students on alcohol pathology and minorities. Ultimately, this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an acfive and successful alcohol research program within the NCCU-BBRI that synergizes with the UNC-ARC to advance education and discoveries.

描述（由申请人提供）：这是北卡罗来纳州中央大学（NCCU）生物医学/生物技术研究所（BBRI）和北卡罗来纳州（北卡罗来纳州）医学院鲍尔斯酒精研究中心的合作协议（U 54）“酒精病理学机制”（MAP）的申请。该提案代表了NCCU和CMARCD教师之间真正的合作努力，这两个团体都做出了重大努力，对CMARCD计划的成功至关重要。在这项提案中，NCCU的行政组成部分和三个研究组成部分将与UNC-ARC行政，教育，5个研究组成部分和核心以及鲍尔斯酒精研究中心的其他活动相结合。UNC-ARC研究酒精病理学的机制，涉及酒精暴露引起的行为、组织和细胞病理学。该提案将侧重于容易纳入UNC-ARC正在进行的总体主题的细胞病理学。因此，UNC-ARC研究部分和U 54提案都围绕着酒精诱导的病理学涉及酒精滥用和酒精中毒发生的分子和细胞变化这一中心主题进行了整合。U 54合作的目标是：1）研究酒精诱导细胞病理学的分子机制。通过对酒精病理学的分子机制进行综合和集中的调查，这一建议将对理解酒精发病率做出重要贡献，并将在NCCU创建一个积极和成功的酒精病理学研究计划; 2）提供酒精病理学的学术教育。本提案中的教育工作将通过合并年度酒精研究日，由NCCU教师开发的新酒精课程，由BBRI主办的酒精研讨会系列，NCCU酒精研究研讨会系列和NCCU酒精病理学和少数民族学生奖学金，教育NCCU学生酒精药理学和酒精相关的病理学和健康差异。最终，该提案将进行，促进，支持和指导酒精病理学机制的研究，在NCCU-BBRI内创建一个acfive和成功的酒精研究计划，与UNC-ARC协同促进教育和发现。