Mechanisms of Alcohol Pathology: A Collaborative Partnership Between NCCU & UNC

酒精病理学机制：国立政治大学之间的合作伙伴关系

• 批准号: 8508753
• 负责人: Gregory Jay Cole
• 金额: $ 84.63万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8508753
• 关键词: Alcohol abuse; Alcoholism; Alcohols; Behavioral; Biotechnology; Education; Educational Curriculum; Faculty; Fellowship; Investigation; Mentors; Minority; Minority-Serving Institution; Molecular; Morbidity - disease rate; North Carolina; Pathology; Research; Research Institute; Series; Students; Tissues; U-Series Cooperative Agreements; Universities; alcohol exposure; alcohol pharmacology; alcohol research; cellular pathology; health disparity; medical schools; problem drinker; programs; success; university student

DESCRIPTION (provided by applicant): This is an application for a cooperative agreement (U54), "Mechanisms of Alcoholic Pathology" (MAP), between faculties of the Biomedical/Biotechnology Research Institute (BBRI) at North Carolina Central University (NCCU), a Minority-Serving Institution, and the Bowles Center for Alcohol Studies at The University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this CMARCD Program. Within this proposal, an NCCU Administrative component and three Research Components will integrate with the UNC-ARC Administrative, Education, 5 Research Components, and Cores, as well as other activities at the Bowles Center for Alcohol Studies. The UNC-ARC investigates mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that easily integrate into the ongoing overall theme of the UNC-ARC. Thus, both the UNC-ARC research components and this U54 proposal are integrated around the central theme that alcohol-induced pathology involves molecular and cellular changes that occur with alcohol abuse and alcoholism. The objectives of this U54 partnership are: 1) To investigate molecular mechanisms of alcohol-induced cellular pathology. By conducting an integrated and focused investigation into the molecular mechanisms of alcohol pathology this proposal will make important contributions to understanding alcohol morbidity and will create an active and successful research program on alcohol pathology at NCCU; 2) To provide scholarly education on Alcohol Pathology. The educational efforts in this proposal will educate NCCU students on alcohol pharmacology and alcohol related pathologies and health disparities through a combined Annual Alcohol Research Day, new alcohol course curricula developed by NCCU faculty, an alcohol seminar series hosted by the BBRI, the UNC Bowles Center for Alcohol Studies seminar series, and NCCU fellowships to students on alcohol pathology and minorities. Ultimately, this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an acfive and successful alcohol research program within the NCCU-BBRI that synergizes with the UNC-ARC to advance education and discoveries.

描述(由申请人提供)：这是北卡罗来纳中央大学(NCCU)生物医学/生物技术研究所(NCCU)的教职员工与北卡罗来纳大学(UNC)医学院鲍尔斯酒精研究中心(Bowles Center For Alcool Studies)的教员之间的一项合作协议(U54)的申请。这项提议代表了NCCU和北卡罗来纳大学教职员工之间真正的合作努力，这两个群体都做出了巨大的努力，对这个CMARCD项目的成功至关重要。在这项提议中，1个NCCU行政部分和3个研究部分将与北卡罗来纳大学-ARC行政、教育、5个研究部分和核心以及鲍尔斯酒精研究中心的其他活动相结合。UNC-ARC研究酒精病理的机制，涉及与酒精暴露有关的行为、组织和细胞病理。这项提案将侧重于容易融入正在进行的UNC-ARC总主题的细胞病理学。因此，北卡罗来纳大学ARC研究部分和这项U54提案都围绕着一个中心主题进行整合，即酒精诱导的病理学涉及酒精滥用和酒精中毒引起的分子和细胞变化。这一U54合作伙伴关系的目标是：1)研究酒精诱导细胞病理的分子机制。通过对酒精病理学的分子机制进行综合和集中的研究，这项建议将对了解酒精发病率做出重要贡献，并将在NCCU创建一个积极和成功的酒精病理学研究项目；2)提供酒精病理学的学术教育。该提案中的教育努力将通过年度酒精研究日、NCCU教职员工开发的新酒精课程课程、由BRI主办的酒精研讨会系列、北卡罗来纳州立大学鲍尔斯酒精研究中心研讨会系列以及NCCU为学生提供的酒精病理学和少数族裔奖学金，向NCCU学生提供酒精药理学和酒精相关病理学以及健康差距方面的教育。最终，这项提案将对酒精病理机制进行、促进、支持和指导研究，在NCCU-BBRI内创建一个成功的酒精研究计划，与北卡罗来纳大学-ARC协同推进教育和发现。