2/2 Mechanisms of alcohol pathology: A collaborative partnership between NCCU & UNC

 描述(由申请人提供)：这是北卡罗来纳中央大学(NCCU)、历史上的黑人学院和大学的教职员工与北卡罗来纳大学(UNC)医学院鲍尔斯酒精研究中心(BCAS)的合作协议(U54)的续签申请。这项提议代表了NCCU和北卡罗来纳大学教职员工之间真正的合作努力，两个小组都做出了重大努力，并对这一成功至关重要 酒精与健康差距研究中心(AHDRC)计划。在这项提议中，NCCU行政核心、指导和发展核心和五个研究部分将与北卡罗来纳大学-BCAS行政、指导和发展核心和研究部分以及鲍尔斯酒精研究中心的其他活动整合在一起。北卡罗来纳大学NIAAA酒精研究中心(ARC)和BCAS有许多教员研究酒精病理的机制，涉及酒精暴露引起的行为、组织和细胞病理的光谱。这项提案将侧重于细胞病理学，允许北卡罗来纳大学和北卡罗来纳大学教职员工在共同感兴趣的领域建立合作研究伙伴关系。这些伙伴关系向NCCU的教职员工开放了北卡罗来纳大学的研究实验室、核心设施和图书馆，增加了在NCCU发展生产性研究实验室的机会。此外，NCCU的大量学生将继续参与酒精病理机制的研究，提供关于非裔美国人与酒精相关的健康差异的教育，这些差异是由于与酒精相关的病理的发病率增加，而不是酒精使用障碍的增加。这个U54伙伴关系的目标是研究酒精诱导的细胞病理的分子机制。这项提案包括NCCU的八个研究项目，这些项目将调查胎儿酒精病理、酒精引起的肝病、酒精引起的口腔癌和乳腺癌以及酒精-大麻类神经毒性的分子机制。第二个目标是为NCCU的学生提供酒精病理学的学术教育。这项建议中的教育工作将包括NCCU本科生和研究生通过BCAS研讨会系列，通过在北卡罗来纳大学实验室和研究开发和导师会议的培训，出席年度RSA会议并介绍数据，NCCU主办的酒精研讨会系列，新课程关于酒精病理学的课程，重点是健康差异，以及为NCCU的学生提供具体的本科生暑期实习，以学习和了解酒精病理与两所院校实验室内的健康差异。最终，这项提案将对酒精病理机制进行、促进、支持和指导研究，在NCCU内创建一个积极而成功的酒精研究计划，与北卡罗来纳大学协同推进教育和发现。

 DESCRIPTION (provided by applicant): This is a renewal application for a cooperative agreement (U54), "Mechanisms of Alcohol Pathology" (MAP), between faculties of North Carolina Central University (NCCU), a Historically Black College and University, and the Bowles Center for Alcohol Studies (BCAS) at The University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this Alcohol and Health Disparity Research Center (AHDRC) Program. Within this proposal, an NCCU Administrative Core, Mentoring and Development Core, and five Research Components will integrate with the UNC-BCAS Administrative, Mentoring and Development Cores and Research Components, as well as other activities at the Bowles Center for Alcohol Studies. The UNC NIAAA Alcohol Research Center (ARC) and BCAS have many faculty studying mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that allow collaborative research partnerships on common areas of interest between UNC and NCCU faculty. These partnerships open UNC research laboratories, core facilities and libraries to NCCU faculty improving opportunities for developing productive research laboratories at NCCU. In addition, large numbers of NCCU students will continue to become involved in research on mechanisms of alcohol pathologies providing education on African-American alcohol related health disparities which are due to increased morbidity to alcohol related pathologies and not increased alcohol use disorder. The objectives of this U54 partnership are to investigate molecular mechanisms of alcohol- induced cellular pathology. This proposal includes eight NCCU research projects that will investigate the molecular mechanisms of fetal alcohol pathology, alcohol induced liver disease, alcohol induced oral and breast cancers as well as alcohol-cannabinoid neurotoxicity. A second objective is to provide scholarly education on Alcohol Pathology for NCCU students. The educational efforts in this proposal will involve NCCU undergraduate and graduate students through the BCAS seminar series, through training in UNC laboratories and research development and mentor meetings, attendance and presentation of data at the annual RSA meeting, an alcohol seminar series hosted by NCCU, a new course curricula on alcohol pathology developed with a focus on health disparities, as well as specific undergraduate student summer internships for NCCU students to study and learn about alcohol pathology and health disparities within laboratories in both institutions. Ultimately this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an active and successful alcohol research program within NCCU that synergizes with UNC to advance education and discoveries.