Response variability in primary auditory cortex of behaving squirrel monkey

行为松鼠猴初级听觉皮层的反应变异性

• 批准号: 8141348
• 负责人: STEPHEN G LISBERGER
• 金额: $ 19.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141348
• 关键词: Address; Affect; Afferent Neurons; Animals; Attention; Auditory; Auditory area; Behavior; Behavioral; Birds; Cell physiology; Code; Detection; Discrimination; Electrodes; Elements; Exhibits; Frequencies; Generations; Goals; Incidence; Learning; Link; Maps; Measurement; Measures; Methods; Modality; Monkeys; Motor; Nature; Neurons; Operant Conditioning; Outcome; Perceptual learning; Performance; Positioning Attribute; Process; Psychophysiology; Rattus; Regimen; Research; Rodent; Role; Saimiri; Sensory; Stimulus; Stratum Granulosum; System; Task Performances; Testing; Training; Variant; awake; base; improved; interest; operation; programs; receptive field; relating to nervous system; research study; response; sensorimotor system; sensory stimulus; sound

The auditory cortex exhibits a broad range of response modes spanning from phasic, single spike or binary responses to tonic, multi-spike, sustained random firing sequences per stimulus. The goal of this project is to determine the character of response variability of different types of auditory cortical neurons in the awaken squirrel monkey. This will allow us to assess the potential role and influence of variability on neuronal encoding, and its impact on behavioral performance and to compare the results to other response modalities. To achieve this, it is necessary to obtain simultaneous estimates of neural and behavioral performance in the awaken animal. Response variability will be assessed under three conditions, in the passive listening animal to serve as a baseline, in the animal actively involved in a behavioral sound discrimination task to assess attention effects, and in animals that are highly trained to assess the effects of learning on the expression of response variability. In conjunction with the other projects, these studies will contribute to establishing general rules, across sensory and motor systems, of the nature and role of response variability in the generation of behavior.

听觉皮层表现出广泛的反应模式，从阶段性的，单一的尖峰或二进制 对每次刺激的强直、多尖峰、持续随机放电序列的反应。该项目的目标是 测定清醒时不同类型听皮层神经元的反应变异性特征 松鼠猴这将使我们能够评估变异性对神经元的潜在作用和影响。 编码，及其对行为表现的影响，并将结果与其他反应进行比较 方式。为了实现这一点，有必要同时获得神经和行为的估计， 动物觉醒的表现将在三种条件下评估响应变异性， 以被动听音动物作为基线，在动物积极参与某一行为时发出声音 辨别任务，以评估注意力的影响，并在动物，是经过高度训练，以评估的影响， 学习反应变异性的表达。与其他项目一起，这些研究将 有助于建立一般规则，在感觉和运动系统，的性质和作用， 行为产生的反应变异性。