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中文摘要
翻译
感觉和运动皮层通过处理视觉信息,共同为运动提供视觉指导
英文摘要
Sensory and motor cortices cooperate to provide the visual guidance of movement by processing visual inputs and providing voluntary modulation of how strongly those inputs reach sub-cortical motor circuits. The present proposal uses smooth pursuit eye movements to ask how visual and motor cortex interact to produce smooth pursuit eye movements. First, it will study the neural basis for “gain-control”. In pursuit, the smooth eye movement region of the frontal eye fields (FEFSEM) modulates the strength of visual-drive for pursuit. Recordings from sensory area MT, motor area FEFSEM, and their brainstem targets will ask how gain control is represented a) when a target is perturbed during pursuit or fixation and b) for high-contrast and low- contrast visual stimuli, which produce high and low gains in the initiation of pursuit. Second, the research will evaluate the neural basis for pursuit latency. It will expand on preliminary data showing a trial-by-trial relationship between neural and pursuit latency in MT. It will ask whether latency or response amplitude in FEFSEM is better related to pursuit latency. It also will record from multiple single neurons in both structures to document how strongly the latencies are correlated across the population. Third, the proposed research will record simultaneously from multiple single neurons in MT and FEFSEM to determine the nature of the functional connectivity between the two areas, and to provide data that constrain how signals are transformed as they move from sensory to motor areas of the cortex. Integrated computational analyses will inform the experimental approaches by answering key questions such as: 1) how is the output from area MT used simultaneously to estimate the speed and direction of target motion and to determine how strongly the motor system should weight sensory evidence; 2) what is the functional connectivity among MT, FEFSEM, and the downstream motor system, and how can the system account for the mean, variation, and correlations among neural and behavioral responses; 3) How do MT and FEFSEM interact to control pursuit latency. The proposed research will make large steps towards understanding how multiple sites within the circuit for pursuit eye movements coordinate visual guidance of movement.
期刊论文(4)
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会议论文
DOI: 10.1038/s41467-022-29457-4
发表时间: 2022-04-05
期刊: Nature communications
影响因子: 16.6
作者: [Egger SW, Lisberger SG]
通讯作者: Lisberger SG
Toward a Biomimetic Neural Circuit Model of Sensory-Motor Processing.
走向感觉运动处理的仿生神经回路模型。
DOI: 10.1162/neco_a_01516
发表时间: 2023
期刊: Neural computation
影响因子: 2.9
作者: [Lisberger,StephenG]
通讯作者: Lisberger,StephenG
A sensory-motor decoder that transforms neural responses in extrastriate area MT into smooth pursuit eye movements.
一种感觉运动解码器,可将纹外区域 MT 的神经反应转化为平滑的眼球追踪运动。
DOI: 10.1101/2023.05.12.540526
发表时间: 2023
期刊: bioRxiv : the preprint server for biology
影响因子: --
作者: [Behling,Stuart, Lisberger,StephenG]
通讯作者: Lisberger,StephenG
Neural mechanisms of visual-motor control in smooth pursuit eye movement
  • 批准号:
    10711146
  • 项目类别:
  • 资助金额:
    $63.83万
  • 财政年份:
    2023
  • 负责人:
    STEPHEN G LISBERGER
  • 依托单位:
Neural Basis for Cerebellar Motor Learning
  • 批准号:
    9101364
  • 项目类别:
  • 资助金额:
    $50.42万
  • 财政年份:
    2016
  • 负责人:
    STEPHEN G LISBERGER
  • 依托单位:
The role of neural variability in production and plasticity of birdsong
Role of variation in the developmental acquisition, and the adult plasticity, of
国内基金
海外基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
  • 批准号:
    2021JJ40433
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2021
  • 负责人:
    孙磊
  • 依托单位:
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
  • 批准号:
    32001603
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2020
  • 负责人:
    段真珍
  • 依托单位:
AREA国际经济模型的移植.改进和应用
  • 批准号:
    18870435
  • 项目类别:
    面上项目
  • 资助金额:
    2.0万元
  • 批准年份:
    1988
  • 负责人:
    史树中
  • 依托单位: