Mayo Clinic Center for Translational Science Activities

梅奥诊所转化科学活动中心

• 批准号: 8233601
• 负责人: ROBERT A. RIZZA
• 金额: $ 51.57万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8233601
• 关键词: Address; Advisory Committees; Basic Science; Behavioral; Benchmarking; Biology; Caring; Center for Translational Science Activities; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Commit; Communities; Community Health; Development; Education; Educational Curriculum; Electronics; Ensure; Ethics; Evaluation; Feasibility Studies; Fostering; Goals; Health; Health Services; Health Services Research; Home environment; Human; Informatics; Instruction; Interdisciplinary Study; Investigation; Knowledge; Learning; Measures; Medical Informatics; Medical Research; Medicine; Mentors; Methodology; Methods; Mission; Outcome; Patient Care; Patients; Phase; Pilot Projects; Practice based research; Process; Program Evaluation; Provider; Research; Research Design; Research Ethics; Research Personnel; Resources; Schools; Science; Services; Speed; Staging; Structure; Students; System; Training; Training and Education; Translating; Translational Research; Translations; Vision; Work; base; behavioral/social science; biomedical informatics; career development; clinical epidemiology; clinical practice; college; comparative effectiveness; cost; design; effectiveness research; electronic data; experience; health care delivery; health disparity; improved; innovation; multidisciplinary; next generation; novel; programs; skills; social; social science research; tool

The overall goal ofthe Mayo Clinic CTSA is to confinue to build a broad-based and integrated home for clinical and translafional science (CTS) at Mayo Clinic that will ulfimately improve human health. In this context, we seek to make the Mayo CTSA and the resources it leverages both an engine of efficiency for clinical and translational research and at the same fime a driver of innovation. We also seek to integrate our local activities with consortium wide efforts directed at coordination and alignment. To achieve our goal we have six overarching specific aims for this renewal: Aim 1 - Train and maintain an outstanding multidisciplinary clinical and translational sciences workforce. This workforce includes teams of both invesfigators and support staff. Aim 2 - Eliminate barriers to the work of translation. This will be accomplished through a) confinued efforts at regulatory and compliance streamlining, b) provision of outstanding design, biostatisfics, and ethics support for invesfigators, and c) further integration of support services. Aim 3 - Collaborate with providers and communities to improve health care delivery and community health. This includes substantial commitments to practice-based research, communityengaged research and translafing comparative effectiveness research into clinical pracfice. Aim 4 - Deploy advanced facilities and other core resources to increase the value of clinical research. With value defined in this context as the quofient of quality and cost, the goal is to increase quality, decrease costs, and provide resources to the full spectrum of clinical and translational investigafion. Aim 5 - Stimulate novel research directions and methodologies by targeted support of innovative pilot and feasibility studies and fostering the development of novel methodologies. Aim 6 - Employ informatics to integrate and facilitate clinical and translational investigation. This encompasses a broad view of informafics including: a) developing a standardized electronic data capture and analysis tools for CTS, b) robust consultafion and tools for medical informatics that leverage Mayo's commitments to electronic clinical systems, and c) bioinformafics services and capabilities that will help facilitate the applicafion of the "new biology" to clinical and translafional invesfigafion. This vision is enfirely consistent with the stated mission of Mayo Clinic: "To provide the best care to every patient every day through integrated clinical practice, education, and research."

梅奥诊所CTSA的总体目标是继续建立一个基础广泛的综合家庭

项目成果

Pathways of translation: deep brain stimulation.

• DOI: 10.1111/cts.12055
• 发表时间: 2013-12
• 期刊: Clinical and translational science
• 作者: Gionfriddo MR;Greenberg AJ;Wahegaonkar AL;Lee KH
• 通讯作者: Lee KH

Translating gene transfer: a stalled effort.

翻译基因转移：一项停滞不前的努力。

• DOI: 10.1111/j.1752-8062.2011.00297.x
• 发表时间: 2011
• 期刊: Clinical and translational science
• 作者: Greenberg,AlexandraJ;McCormick,Jennifer;Tapia,CarmenJ;Windebank,AnthonyJ
• 通讯作者: Windebank,AnthonyJ

Incidental findings in imaging research: evaluating incidence, benefit, and burden.

• DOI: 10.1001/archinternmed.2010.317
• 发表时间: 2010-09-27
• 期刊: ARCHIVES OF INTERNAL MEDICINE
• 作者: Orme, Nicholas M.;Fletcher, Joel G.;Siddiki, Hassan A.;Harmsen, W. Scott;O'Byrne, Megan M.;Port, John D.;Tremaine, William J.;Pitot, Henry C.;McFarland, Elizabeth G.;Robinson, Marguerite E.;Koenig, Barbara A.;King, Bernard F.;Wolf, Susan M.
• 通讯作者: Wolf, Susan M.

Heat Stress and Thermal Ablation Induce Local Expression of Nerve Growth Factor Inducible (VGF) in Hepatocytes and Hepatocellular Carcinoma: Preclinical and Clinical Studies.

• DOI: 10.3727/105221618x15305531034617
• 发表时间: 2018-12
• 期刊: Gene expression
• 作者: S. Thompson;Danielle E Jondal;K. Butters;B. Knudsen;Jill L. Anderson;L. Roberts;M. Callstrom;D. Woodrum

Neuromyelitis optica IgG serostatus in fulminant central nervous system inflammatory demyelinating disease.

暴发性中枢神经系统炎症性脱髓鞘疾病中的视神经脊髓炎 IgG 血清状态。

• DOI: 10.1001/archneurol.2009.152
• 发表时间: 2009
• 期刊: Archives of neurology
• 作者: Magaña,SettyM;Pittock,SeanJ;Lennon,VandaA;Keegan,BMark;Weinshenker,BrianG;Lucchinetti,ClaudiaF
• 通讯作者: Lucchinetti,ClaudiaF