Research Training in the Major Psychoses and Clinical Neurobiology

主要精神病和临床神经生物学的研究培训

• 批准号: 8078370
• 负责人: NANCY C ANDREASEN
• 金额: $ 0.43万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8078370
• 关键词: Clinical; Neurobiology; Psychotic Disorders; Research Training

DESCRIPTION (provided by applicant): This application requests continuation of funding for a very successful and well-established post-doctoral training program (dating back to 1991) in Major Psychoses and Translational Clinical Neuroscience. It seeks to integrate training in translational clinical neuroscience with an emphasis on the study of schizophrenia and other major psychoses using a "lifespan trajectory perspective." That is, trainees may study illnesses during their characteristic age of onset, but they may also examine them from the perspectives of neurodevelopmental and/or aging processes. This program in integrative translational clinical neuroscience will place strong emphasis on all three aspects: "integrative," "translational/clinical," and "neuroscience." The ultimate goal is to train a group of young investigators who will combine a high level of sophistication about the complexities of clinical phenomena with a firm grounding in some specific area of neuroscience, such as neuroimaging, cognitive neuroscience, and genetics/genomics/molecular biology. The program supports five trainee slots/year. Trainees remain in the program for a minimum of two years, and many elect to continue their training for a total of three years because of the complexities inherent in doing sophisticated integrative translational clinical neuroscience. The minimum experience required for entry into the program is a doctoral degree (M.D., Ph.D.), but many of our trainees have also completed residency training and have M.D./Ph.D.s. Relevance An integration of basic and clinical science will, we hope, help identify the mechanisms and causes of the major psychoses and to suggest improved methods for treating or preventing them. The disorders studied through this program (schizophrenia, depression, and bipolar illness) are three of the top ten contributors to the "global burden of disease," according to a recent study by the World Health Organization. Thus it is crucial that we train a young generation of investigators who will advance knowledge about these diseases over the coming decades. PUBLIC HEALTH RELEVANCE: The disorders studied through this program (schizophrenia, depression, and bipolar illness) are three of the top ten contributors to the "global burden of disease," according to a recent study by the World Health Organization. Thus it is crucial that we train a young generation of investigators who will advance knowledge about these diseases over the coming decades. 20

描述（由申请人提供）：本申请要求继续为重大精神病和转化临床神经科学领域非常成功且完善的博士后培训计划（可追溯至 1991 年）提供资金。它寻求将转化临床神经科学的培训与重点使用“寿命轨迹视角”对精神分裂症和其他主要精神病的研究结合起来。也就是说，受训者可以在其特征性发病年龄期间研究疾病，但他们也可以从神经发育和/或衰老过程的角度来检查它们。该综合转化临床神经科学项目将重点强调所有三个方面：“综合”、“转化/临床”和“神经科学”。最终目标是培养一批年轻的研究人员，他们将对临床现象的复杂性具有高度的了解，并在神经科学的某些特定领域（例如神经影像学、认知神经科学和遗传学/基因组学/分子生物学）拥有坚实的基础。该计划每年支持五个实习生名额。受训者在该计划中至少停留两年，许多人选择继续接受总共三年的培训，因为进行复杂的综合转化临床神经科学固有的复杂性。进入该计划所需的最低经验是博士学位（M.D.、Ph.D.），但我们的许多学员也完成了住院医师培训并拥有 M.D./Ph.D.。相关性我们希望，基础科学和临床科学的结合将有助于确定主要精神病的机制和原因，并提出治疗或预防这些疾病的改进方法。根据世界卫生组织最近的一项研究，通过该项目研究的疾病（精神分裂症、抑郁症和双向情感障碍）是造成“全球疾病负担”的十大因素中的三种。因此，我们培训年轻一代的研究人员至关重要，他们将在未来几十年内增进对这些疾病的了解。 公共卫生相关性：根据世界卫生组织最近的一项研究，通过该计划研究的疾病（精神分裂症、抑郁症和双向情感障碍）是造成“全球疾病负担”的十大因素中的三种。因此，我们培训年轻一代的研究人员至关重要，他们将在未来几十年内增进对这些疾病的了解。 20