Research Training in Pediatric Cardiology

描述（由申请人提供）：本申请请求继续支持拨款T32 HL 007710，目标是增加专注于儿科心血管疾病的成功临床和转化研究者的数量和质量。在这项资助的头14年期间，35名受训者的研究生产力和学术职业发展是可观的。在这一竞争性更新申请中，我们描述了培训和指导儿科心脏病学研究人员的计划，这些研究人员以患者为导向，并专注于儿科心脏病学的重大挑战。该计划为儿科心脏病学（MD）研究员提供两种模式研究培训途径：临床研究者和转化临床医生科学家途径。每个受训者都将有一个由临床和基础科学导师组成的初级导师和指导团队，从而增加思想和经验的广度，以促进职业发展。该计划确定并促进每个学员理想的个性化培训目标，以最大限度地提高他或她的机会，成为一个富有成效的学术研究者与可持续竞争力的校外研究支持。整合到该研究培训计划中的MUSC的科学和规划资源包括作为NHLBI儿科心脏网络的主要临床中心的参与；蓬勃发展的临床儿科心脏病学奖学金培训计划；一个儿科心脏病学和儿科心脏外科的合作临床教师，拥有广泛的出版物，研究资金和参与多机构研究的记录；在心血管发育生物学、心脏形态发生、细胞外基质生物学、心脏肥厚、重塑、伤口愈合、细胞修复、干细胞生物学、组织工程、生物工程和假体装置开发等方面具有突出的师资优势；通过美国国立卫生研究院资助的CTSA项目，在临床研究方法方面提供广泛的教学培训机会；一个完善的，成功的临床研究硕士学位课程；临床和基础科学研究环境，证明少数族裔招聘成功；实质性的机构承诺；达比儿童研究所；以及NIH/NCRR心血管发育生物学生物医学卓越研究中心（COBRE）。一个综合的多年评估计划将记录和评估项目目标达到的程度，并为持续改进和增强提供关键信息。

DESCRIPTION (provided by applicant): This application requests continued support of grant T32 HL 007710 with the goal of increasing the number and quality of successful clinical and translational investigators focused on pediatric cardiovascular disease. The research productivity and academic career advancement of the 35 trainees supported during the first 14 years of this grant are substantial. In this competing renewal application, we describe plans for training and mentoring pediatric cardiology research fellows in patient-oriented and translational research focused on significant challenges in pediatric cardiology. The program has two model research training pathways for pediatric cardiology (MD) fellows: the Clinical Investigator and Translational Clinician Scientist Pathways. Each trainee will have a Primary l\/ lentor and Mentoring Team composed of both clinical and basic science mentors, thereby increasing the breadth of ideas and experience available to enhance career development. The program identifies and promotes desirable individualized training goals for each trainee in order to maximize his or her opportunity to become a productive academic investigator with sustainable competitiveness for extramural research support. Scientific and programmatic resources at MUSC that are integrated into this research training program include participation as a primary Clinical Center in the NHLBI Pediatric Heart Network; a thriving clinical pediatric cardiology fellowship training program; a collaborative clinical faculty in pediatric cardiology and pediatric cardiac surgery with an extensive track record of publications, research funding and participation in multi-institutional studies; exceptional faculty strengths in cardiovascular developmental biology, cardiac morphogenesis, extracellular matrix biology, cardiac hypertrophy, remodeling, wound healing, cellular repair, stem cell biology, tissue engineering, bioengineering and prosthetic device development; a wide array of didactic training opportunities in clinical research methodology through the NIH-funded CTSA program; a well-developed, successful Master of Science in Clinical Research degree program; clinical and basic science research environments with proven minority recruitment success; substantial institutional commitment; the Darby Children's Research Institute; and an NIH/NCRR Center of Biomedical Research Excellence (COBRE) in cardiovascular developmental biology. An integrated multi-year evaluation plan will document and assess the extent to which program goals and objectives are met and provide critical information for ongoing improvement and enhancement.