The neural organization of face and object patches in inferotemporal cortex
颞下皮层面部和物体斑块的神经组织
基本信息
- 批准号:8047967
- 负责人:
- 金额:$ 5.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-03-17 至 2012-03-16
- 项目状态:已结题
- 来源:
- 关键词:AddressAreaBehavioralBrainCellsDevelopmentElectrodesExhibitsFaceFamiliarityFunctional Magnetic Resonance ImagingGoalsHumanImageImaging technologyKnowledgeLocationMagnetic Resonance ImagingMapsMeasurementMeasuresMemoryNeuronsPerceptionPopulationProcessPropertyProsthesisResolutionSamplingSeriesShapesStagingStructureSystemTechniquesTestingVisionVisualVisual system structureWorkbasebiological systemsexperiencefallsimprovedinferotemporal cortexinsightinterestneural prosthesisnext generationnoveloptical imagingrelating to nervous systemrepairedvisual processvisual processing
项目摘要
DESCRIPTION (provided by applicant): The brain's remarkable ability to recognize and remember objects depends on a series of visual processing stages culminating in inferotemporal cortex (IT). As the highest purely visual processing stage, IT contains dedicated domains for processing specific object classes, such as faces. Little is known, however, about the detailed organization and properties of neurons within these domains. The goal of this proposal is to provide such information by precisely targeting neural recordings to face and object selective regions of IT. An integrated system will be developed that uses fMRI to localize regions of interest and a novel x-ray based technique to return neural coordinates within these regions. Our first aim will be to measure the selectivity and tolerance properties of neurons throughout the 3D extent of an fMRI defined object patch. Different hypotheses about fine scale organization will be tested, and the underlying selectivity of neural populations compared to selectivity measured by fMRI. The second aim of our proposal will compare the organization in a face patch with a patch for novel objects. Face selective cells are already known to exist in face patches, but the question to be addressed is how the number, organization, or strength of tuning of cells in face patches differs from that in regions selective to unfamiliar objects. Such information will provide insights into how IT is organized across objects and whether strong familiarity with objects like faces refines neural maps. By bridging the gap between human fMRI and underlying neural structures, this work directly impacts our understanding of human object selective cortex. In case of loss of visual function, object level domains at the interface of memory and perception are prime targets for visual neural prosthetics. Knowledge of their precise locations and structures will guide repair and lay groundwork for the development of next-generation prosthetics.
描述(由申请人提供):大脑识别和记忆物体的卓越能力依赖于以颞下皮层(IT)为高潮的一系列视觉处理阶段。作为最高级的纯视觉处理阶段,IT包含用于处理特定对象类(如人脸)的专用领域。然而,人们对这些区域内神经元的详细组织和特性知之甚少。该建议的目标是通过精确地将神经记录定向到IT的面部和对象选择区域来提供这些信息。将开发一个集成系统,使用功能磁共振成像来定位感兴趣的区域,并使用一种新的基于x射线的技术来返回这些区域内的神经坐标。我们的第一个目标是在fMRI定义的物体贴片的整个3D范围内测量神经元的选择性和耐受性。将测试关于精细尺度组织的不同假设,并将神经种群的潜在选择性与fMRI测量的选择性进行比较。我们建议的第二个目标是比较面部贴片和新物体贴片中的组织。人脸选择细胞已知存在于人脸斑块中,但需要解决的问题是,人脸斑块中细胞的数量、组织或调节强度与选择不熟悉物体的区域有何不同。这些信息将有助于了解IT是如何跨对象组织的,以及对人脸等对象的高度熟悉是否会改善神经地图。通过弥合人类功能磁共振成像和潜在神经结构之间的差距,这项工作直接影响了我们对人类目标选择皮层的理解。在视觉功能丧失的情况下,记忆和感知界面的物体层次域是视觉神经修复的主要目标。了解它们的精确位置和结构将指导修复,并为下一代假肢的发展奠定基础。
项目成果
期刊论文数量(0)
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Elias Issa其他文献
Elias Issa的其他文献
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{{ truncateString('Elias Issa', 18)}}的其他基金
Multiscale imaging of marmoset cortex during visual object recognition and learning
狨猴皮层在视觉对象识别和学习过程中的多尺度成像
- 批准号:
9978313 - 财政年份:2020
- 资助金额:
$ 5.13万 - 项目类别:
The role of cortical feedback in visual face processing
皮层反馈在视觉面部处理中的作用
- 批准号:
8528613 - 财政年份:2012
- 资助金额:
$ 5.13万 - 项目类别:
The role of cortical feedback in visual face processing
皮层反馈在视觉面部处理中的作用
- 批准号:
8354364 - 财政年份:2012
- 资助金额:
$ 5.13万 - 项目类别:
The neural organization of face and object patches in inferotemporal cortex
颞下皮层面部和物体斑块的神经组织
- 批准号:
7809569 - 财政年份:2009
- 资助金额:
$ 5.13万 - 项目类别:
The neural organization of face and object patches in inferotemporal cortex
颞下皮层面部和物体斑块的神经组织
- 批准号:
7672700 - 财政年份:2009
- 资助金额:
$ 5.13万 - 项目类别:
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