Mentoring translational cognitive science for stroke recovery

指导中风康复的转化认知科学

• 批准号: 8123315
• 负责人: A. M. Barrett
• 金额: $ 14.06万
• 依托单位: KESSLER FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-10 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8123315
• 关键词: Acute; Aftercare; American; Anatomic Models; Animal Model; Animals; Applications Grants; Award; Ballistics; Behavioral; Brain; Brain Injuries; Bromocriptine; Caring; Cerebrum; Chronic; Clinical; Clinical Research; Clinical Treatment; Cognitive; Cognitive Science; Collaborations; Commit; Detection; Disease; Feedback; Funding; Goals; Handedness; Hospitalization; Hypokinesia; Inpatients; International; Intervention; Laboratories; Laboratory Research; Learning; Left; Manuscripts; Measures; Medical; Medical Students; Mentors; Methods; Midcareer Investigator Award in Patient-Oriented Research; Morbidity - disease rate; Motor; Movement; Neurorehabilitation; Neurosciences; Outcome; Patients; Perception; Performance; Pharmaceutical Preparations; Physical Medicine; Physicians; Physiological; Postdoctoral Fellow; Primates; Psychological Theory; Rattus; Reading; Recovery; Rehabilitation Outcome; Rehabilitation therapy; Research; Research Personnel; Research Project Grants; Rotation; Savings; Science; Stimulus; Stratification; Stroke; Survivors; System; Techniques; Testing; Time; Training; United States National Institutes of Health; Vision; Vision Disorders; Visual; Walking; Wheelchairs; Work; acute stroke; base; cost; disability; distraction; functional disability; improved; next generation; novel; post stroke; programs; response; role model; spatial neglect; stroke recovery; stroke rehabilitation; theories; treatment response; visual feedback

DESCRIPTION (provided by applicant): Post-stroke, functional visual problems are frequently cerebral rather than ocular. However, brain systems are not the basis of current rehabilitation. Even marginally better outcomes in estimated 230,000 US acute stroke survivors with spatial neglect could result in annual savings > $200 million. The Candidate proposed that better spatial neglect rehabilitation outcomes may result from appropriate subject stratification: performance supported by dopaminergic "aiming" systems, as well as established perceptual "where" brain networks, determined recovery in classical animal studies. With outstanding mentoring and training, under a K08 award she developed and validated a spatial neglect assessment method quantifying these recovery components. Novel K02 studies further demonstrated that "aiming" and "where" functional stratification correlated with recovery and response to clinical treatment. Continuous NIH funding since 1999 allowed her to apply the translational stratification hypothesis to neurorehabilitation research, attracting numerous clinician-researcher trainees for hands-on training. Recently, R01 funding allows her to expand her research goals, investigating translational stratification of recovery trajectory in larger groups of stroke survivors with spatial neglect. A physician cognitive neuroscientist applying psychological theory to stroke rehabilitation, she is a unique role model for medical trainees at three distinct levels. Medical students compete for research laboratory rotations, and are mentored individually in clinical research. Physiatric resident physicians are mentored in clinical research, and physiatric residents and post-doctoral fellows perform program-required research in her laboratory, resulting in trainee-authored manuscripts and presentations (5 in 2008). The K24 mechanism provides critical protected time for the Candidate to expand the theoretical basis of her clinical research, and commit appropriately to mentoring activities. The proposal activities also build her collaboration with Anne Foundas, MD. Their developing translational neuro- anatomic model, to potentially predict recovery and response to spatial neglect treatment after stroke, is expected to generate novel hypotheses for further trainee-mentor collaboration and grant applications.

描述（由申请人提供）：中风后，功能性视力问题通常是大脑而不是眼睛。然而，大脑系统并不是当前康复的基础。即使是稍微好一点的结果，估计23万美国急性中风幸存者的空间忽视可以每年节省2亿美元。候选人提出，更好的空间忽视康复结果可能源于适当的受试者分层：由多巴胺能“瞄准”系统支持的表现，以及在经典动物研究中建立的感知“何处”大脑网络，决定了恢复。在出色的指导和培训下，她开发并验证了一种量化这些恢复成分的空间忽视评估方法，并获得了K08奖。新的K02研究进一步表明，“瞄准”和“何处”功能分层与临床治疗的恢复和反应相关。自1999年以来，美国国立卫生研究院的持续资助使她能够将翻译分层假说应用于神经康复研究，吸引了众多临床研究员实习生进行实践培训。最近，R01基金允许她扩大她的研究目标，研究空间忽视的中风幸存者群体中康复轨迹的翻译分层。作为一名将心理学理论应用于中风康复的内科认知神经科学家，她在三个不同的层面上为医学培训生树立了独特的榜样。医学生竞争研究实验室轮转，并在临床研究中单独指导。物理住院医师在临床研究中接受指导，物理住院医师和博士后研究员在她的实验室进行项目要求的研究，产生实习生撰写的手稿和报告（2008年5篇）。K24机制为候选人提供了关键的保护时间，以扩展其临床研究的理论基础，并适当地致力于指导活动。提案活动还建立了她与Anne Foundas医学博士的合作。他们正在开发的转化神经解剖学模型，可以潜在地预测中风后空间忽视治疗的恢复和反应，有望为进一步的实习生-导师合作和资助申请产生新的假设。