Mentoring translational cognitive science for stroke recovery

描述(申请人提供)：中风后，功能性视觉问题通常是脑部而不是眼睛。然而，大脑系统并不是目前康复的基础。在估计有空间忽视的23万名美国急性中风幸存者中，即使是稍微好一点的结果，每年也可以节省2亿美元。这位候选人提出，更好的空间忽视康复结果可能来自适当的受试者分层：在经典动物研究中，由多巴胺能“瞄准”系统支持的表现，以及已建立的知觉“Where”脑网络，决定了恢复。在出色的指导和培训下，在K08奖下，她开发并验证了一种量化这些康复组成部分的空间忽视评估方法。新的K02研究进一步证明，“瞄准”和“在哪里”的功能分层与临床治疗的恢复和反应有关。自1999年以来，NIH持续不断的资助使她能够将翻译分层假说应用于神经康复研究，吸引了无数临床医生-研究人员实习生进行实践培训。最近，R01基金允许她扩大她的研究目标，在更大的空间忽视中风幸存者群体中调查康复轨迹的翻译分层。她是一位将心理学理论应用于中风康复的内科认知神经学家，在三个不同的水平上为医学实习生树立了独特的榜样。医学生竞争研究实验室的轮换，并在临床研究中得到单独的指导。物理住院医师指导临床研究，物理住院医师和博士后研究员在她的实验室进行项目要求的研究，产生实习生撰写的手稿和演示文稿(2008年5篇)。K24机制为候选人提供了关键的保护时间，以扩大她的临床研究的理论基础，并适当地致力于指导活动。求婚活动还建立了她与医学博士安妮·方达斯的合作。他们正在开发的翻译神经解剖学模型，潜在地预测中风后空间忽视治疗的恢复和反应，预计将为进一步的实习生-导师合作和拨款申请产生新的假设。

DESCRIPTION (provided by applicant): Post-stroke, functional visual problems are frequently cerebral rather than ocular. However, brain systems are not the basis of current rehabilitation. Even marginally better outcomes in estimated 230,000 US acute stroke survivors with spatial neglect could result in annual savings > $200 million. The Candidate proposed that better spatial neglect rehabilitation outcomes may result from appropriate subject stratification: performance supported by dopaminergic "aiming" systems, as well as established perceptual "where" brain networks, determined recovery in classical animal studies. With outstanding mentoring and training, under a K08 award she developed and validated a spatial neglect assessment method quantifying these recovery components. Novel K02 studies further demonstrated that "aiming" and "where" functional stratification correlated with recovery and response to clinical treatment. Continuous NIH funding since 1999 allowed her to apply the translational stratification hypothesis to neurorehabilitation research, attracting numerous clinician-researcher trainees for hands-on training. Recently, R01 funding allows her to expand her research goals, investigating translational stratification of recovery trajectory in larger groups of stroke survivors with spatial neglect. A physician cognitive neuroscientist applying psychological theory to stroke rehabilitation, she is a unique role model for medical trainees at three distinct levels. Medical students compete for research laboratory rotations, and are mentored individually in clinical research. Physiatric resident physicians are mentored in clinical research, and physiatric residents and post-doctoral fellows perform program-required research in her laboratory, resulting in trainee-authored manuscripts and presentations (5 in 2008). The K24 mechanism provides critical protected time for the Candidate to expand the theoretical basis of her clinical research, and commit appropriately to mentoring activities. The proposal activities also build her collaboration with Anne Foundas, MD. Their developing translational neuro- anatomic model, to potentially predict recovery and response to spatial neglect treatment after stroke, is expected to generate novel hypotheses for further trainee-mentor collaboration and grant applications.