Mentoring translational cognitive science for stroke recovery

指导中风康复的转化认知科学

• 批准号: 8318153
• 负责人: A. M. Barrett
• 金额: $ 13.98万
• 依托单位: KESSLER FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-10 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318153
• 关键词: Acute; Aftercare; American; Anatomic Models; Animal Model; Animals; Applications Grants; Award; Ballistics; Behavioral; Brain; Brain Injuries; Bromocriptine; Caring; Cerebrum; Chronic; Clinical; Clinical Research; Clinical Treatment; Cognitive; Cognitive Science; Collaborations; Commit; Detection; Disease; Feedback; Funding; Goals; Handedness; Hospitalization; Hypokinesia; Inpatients; International; Intervention; Laboratories; Laboratory Research; Learning; Left; Manuscripts; Measures; Medical; Medical Students; Mentors; Methods; Midcareer Investigator Award in Patient-Oriented Research; Morbidity - disease rate; Motor; Movement; Neurorehabilitation; Neurosciences; Outcome; Patients; Perception; Performance; Pharmaceutical Preparations; Physical Medicine; Physicians; Physiological; Postdoctoral Fellow; Primates; Psychological Theory; Rattus; Reading; Recovery; Rehabilitation Outcome; Rehabilitation therapy; Research; Research Personnel; Research Project Grants; Rotation; Savings; Science; Stimulus; Stratification; Stroke; Survivors; System; Techniques; Testing; Time; Training; United States National Institutes of Health; Vision; Vision Disorders; Visual; Walking; Wheelchairs; Work; acute stroke; base; cost; disability; distraction; functional disability; improved; next generation; novel; post stroke; programs; response; role model; spatial neglect; stroke recovery; stroke rehabilitation; theories; treatment response; visual feedback

DESCRIPTION (provided by applicant): Post-stroke, functional visual problems are frequently cerebral rather than ocular. However, brain systems are not the basis of current rehabilitation. Even marginally better outcomes in estimated 230,000 US acute stroke survivors with spatial neglect could result in annual savings > $200 million. The Candidate proposed that better spatial neglect rehabilitation outcomes may result from appropriate subject stratification: performance supported by dopaminergic "aiming" systems, as well as established perceptual "where" brain networks, determined recovery in classical animal studies. With outstanding mentoring and training, under a K08 award she developed and validated a spatial neglect assessment method quantifying these recovery components. Novel K02 studies further demonstrated that "aiming" and "where" functional stratification correlated with recovery and response to clinical treatment. Continuous NIH funding since 1999 allowed her to apply the translational stratification hypothesis to neurorehabilitation research, attracting numerous clinician-researcher trainees for hands-on training. Recently, R01 funding allows her to expand her research goals, investigating translational stratification of recovery trajectory in larger groups of stroke survivors with spatial neglect. A physician cognitive neuroscientist applying psychological theory to stroke rehabilitation, she is a unique role model for medical trainees at three distinct levels. Medical students compete for research laboratory rotations, and are mentored individually in clinical research. Physiatric resident physicians are mentored in clinical research, and physiatric residents and post-doctoral fellows perform program-required research in her laboratory, resulting in trainee-authored manuscripts and presentations (5 in 2008). The K24 mechanism provides critical protected time for the Candidate to expand the theoretical basis of her clinical research, and commit appropriately to mentoring activities. The proposal activities also build her collaboration with Anne Foundas, MD. Their developing translational neuro- anatomic model, to potentially predict recovery and response to spatial neglect treatment after stroke, is expected to generate novel hypotheses for further trainee-mentor collaboration and grant applications.

描述（由申请人提供）：中风后，功能性视力问题通常是大脑而不是眼睛。然而，大脑系统并不是目前康复的基础。在估计的230，000名患有空间忽视的美国急性卒中幸存者中，即使结果稍微好一点，也可能导致每年节省超过2亿美元。候选人提出，更好的空间忽视康复结果可能来自适当的受试者分层：多巴胺能“瞄准”系统支持的表现，以及建立的感知“哪里”大脑网络，在经典动物研究中确定恢复。凭借出色的指导和培训，在K 08奖下，她开发并验证了一种量化这些恢复组件的空间忽视评估方法。新的K 02研究进一步证明，“瞄准”和“在哪里”功能分层与临床治疗的恢复和反应相关。自1999年以来，NIH的持续资助使她能够将翻译分层假设应用于神经康复研究，吸引了众多临床研究人员实习生进行实践培训。最近，R 01基金使她能够扩大她的研究目标，调查在较大的中风幸存者空间忽视群体中恢复轨迹的平移分层。作为一名将心理学理论应用于中风康复的认知神经科学家，她是三个不同层次的医学实习生的独特榜样。医学生竞争研究实验室轮换，并在临床研究中单独指导。物理住院医师在临床研究中得到指导，物理住院医师和博士后研究员在她的实验室进行项目要求的研究，产生受训者撰写的手稿和演示文稿（2008年5）。K24机制为候选人提供了关键的保护时间，以扩展其临床研究的理论基础，并适当地致力于指导活动。提案活动还建立了她与医学博士Anne Foundas的合作。他们开发的翻译神经解剖模型，可能预测中风后空间忽视治疗的恢复和反应，预计将为进一步的受训者-导师合作和赠款申请产生新的假设。