Center for Visual and Neurocognitive Rehabilitation

视觉和神经认知康复中心

• 批准号: 10782409
• 负责人: A. M. Barrett
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-10-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10782409
• 关键词: Acceleration; Age related macular degeneration; Aging; Alzheimer' s Disease; Animal Experiments; Animal Model; Biomedical Engineering; Brain Diseases; Caring; Collaborations; Communities; Disease; Doctor of Philosophy; Education; Ensure; Extramural Activities; Fostering; Funding; Goals; Grant; Health; Human; Intervention; Joints; Literature; Mentorship; Mission; Molecular Biology; Neurocognitive; Neurocognitive Deficit; Neurology; Ophthalmology; Patients; Personal Satisfaction; Physical Exercise; Physical Medicine; Recovery of Function; Rehabilitation therapy; Research; Research Personnel; Retina; Retinal Degeneration; Scientist; Services; Sleep; Stroke; System; Technology; Testing; Time; Training; Universities; Veterans; Visual; Visual impairment; career development; clinical trials in animals; design; experience; healthy aging; imaging facilities; meetings; military veteran; neural repair; neuroimaging; outreach; preclinical study; prevent; programs; psychoeducation; psychoeducational; recruit; rehabilitation research; repetitive transcranial magnetic stimulation; research and development; research study; synergism; telerehabilitation

The mission of the Atlanta VAMC Rehabilitation Research and Development Center for Visual and Neurocognitive Rehabilitation (CVNR) is to foster the best possible health and well-being of Veterans through uniquely synergistic research studies targeting disorders impacting visual and/or neurocognitive function. Our Center's organization is designed to catalyze synergies amongst collaborating CVNR researchers and with scientist and clinician affiliates to maximize and accelerate tangible benefits for Veterans' health. The Internal Steering Group is the hub of CVNR operational decisions and comprises Krish Sathian, MD, PhD (Executive Director); Bruce Crosson, PhD (Executive Associate Director); Machelle Pardue, PhD (Associate Director for Scientific Projects); Steven Wolf, PT, PhD (Associate Director for Training), Patricia Griffiths, PhD (Assistant Director for Outreach); Keith McGregor, PhD (Career Development Awardees' Representative); and Lisa Calas (Administrative Officer). The CVNR has three Research Programs: (A) Retinal & Neural Repair, (B) Visual Rehabilitation, and (C) Neurocognitive Rehabilitation. The CVNR's emphasis is on highly collaborative research efforts that straddle and integrate across the Programs. To this end, we plan three Integrative Projects that each draw on expertise and ideas from multiple Programs: (1) Physical exercise to prevent progression of age-related macular degeneration in Veterans; (2) Repetitive transcranial magnetic stimulation in aging and stroke: mechanistic pre-clinical studies using animal models; and (3) Making a psycho-educational tele- rehabilitative sleep intervention accessible for Veterans with visual impairment and their cohabitating care- partners. Each of these projects will be funded by the CVNR for an initial 2-year period, with the goal of seeding extramurally funded research by that time. In subsequent years, additional Integrative Projects will be funded after competitive review. Note that the activity of CVNR investigators is not limited to these Integrative Projects; each investigator is involved in multiple other projects that will be further enriched by the experiences and results of the Integrative Projects. The CVNR will also fund a set of Cores to provide services to investigators. Three of these are ongoing: a Neuroimaging Core directed by Dr. Crosson, a Molecular Biology Core directed by Dr. Boatright, and an Administrative Core directed by Ms. Calas. Two additional Cores will be added in year 3 of the new grant cycle: a Physical Exercise Core directed by Dr. Nocera and a Tele-rehabilitation Core co-directed by Drs. Griffiths and McGregor and Mr. Ross. The CVNR has strong ties with local affiliates, including the Birmingham-Atlanta GRECC; Emory University, particularly its imaging centers, its Alzheimer's Disease Research Center, and its Departments of Neurology, Ophthalmology and Rehabilitation Medicine; Georgia Institute of Technology; the joint Biomedical Engineering Department of Emory and Georgia Tech; and Georgia State University. Our research findings will be shared through the national network of Centers, disseminated in the scientific literature and at scientific meetings, presented to VA and other clinicians locally and nationally, and distilled into educational programs for Veterans, other consumer groups, and the community. The CVNR is committed to capacity building by recruiting trainees as well as junior and senior investigators into the VA system and providing trainees with outstanding mentorship to ensure the continued vitality of rehabilitation research.

亚特兰大VAMC康复研究和发展中心的使命是视觉和 神经认知康复（CVNR）是为了促进退伍军人的最佳健康和福祉 通过针对影响视觉和/或神经认知的疾病的独特协同研究， 功能我们中心的组织旨在促进合作的CVNR之间的协同作用 研究人员以及科学家和临床医生附属机构，以最大限度地提高和加快有形效益， 退伍军人的健康内部指导小组是CVNR运营决策的中心，包括 Krish Sathian，MD，PhD（执行董事）;布鲁斯克罗森，PhD（执行副董事）; Machelle Pardue，PhD（科学项目副主任）; Steven Wolf，PT，PhD（ 培训），Patricia Griffiths博士（外联助理主任）;基思麦格雷戈博士（职业 发展奖获得者代表）和丽莎卡拉斯（行政干事）。 CVNR有三个研究项目：（A）视网膜和神经修复，（B）视觉康复， （C）神经认知康复。CVNR的重点是高度合作的研究工作， 跨越并整合各个项目。为此，我们计划了三个综合项目，每个项目 关于多个项目的专业知识和想法：（1）体育锻炼，以防止与年龄有关的进展 退伍军人黄斑变性;（2）老年和中风中的重复经颅磁刺激： 使用动物模型进行的机制性临床前研究;（3）制作心理教育电视节目， 为视力障碍的退伍军人及其同居护理提供康复性睡眠干预- 伙伴这些项目中的每一个都将由CVNR资助，最初为期2年，目标是 在那个时候为研究提供资助在随后的几年里，更多的综合项目将 在竞争性审查后获得资助。请注意，CVNR调查人员的活动不仅限于这些 综合项目;每个研究者都参与了多个其他项目，这些项目将通过以下方式进一步丰富 综合项目的经验和成果。 CVNR还将资助一套核心，为调查人员提供服务。其中三个是 正在进行中：由Crosson博士指导的神经影像学核心，由Boatright博士指导的分子生物学核心， 以及卡拉斯女士领导的行政核心新的第三年将增加两个核心 赠款周期：由Nocera博士指导的体育锻炼核心项目和 Drs.格里菲思，麦格雷戈和罗斯先生. CVNR与当地分支机构有着密切的联系，包括 伯明翰-亚特兰大GRECC;埃默里大学，特别是其成像中心，其阿尔茨海默病 研究中心及其神经病学、眼科学和康复医学系;格鲁吉亚 埃默里大学和格鲁吉亚理工学院联合生物医学工程系; 格鲁吉亚州立大学。 我们的研究成果将通过国家中心网络共享，在 科学文献和科学会议，提交给VA和其他临床医生在当地和国家， 并提炼成退伍军人，其他消费者群体和社区的教育计划。的 CVNR致力于通过招募学员以及初级和高级调查员来进行能力建设 加入退伍军人管理系统，并为学员提供出色的指导，以确保 康复研究。

项目成果

The Utility of Cerebrovascular Reactivity MRI in Brain Rehabilitation: A Mechanistic Perspective.

• DOI: 10.3389/fphys.2021.642850
• 发表时间: 2021
• 期刊: Frontiers in physiology
• 影响因子: 4
• 作者: Krishnamurthy V;Sprick JD;Krishnamurthy LC;Barter JD;Turabi A;Hajjar IM;Nocera JR
• 通讯作者: Nocera JR

The Relationship Between Resting Cerebral Blood Flow, Neurometabolites, Cardio-Respiratory Fitness and Aging-Related Cognitive Decline.

• DOI: 10.3389/fpsyt.2022.923076
• 发表时间: 2022
• 期刊: FRONTIERS IN PSYCHIATRY
• 影响因子: 4.7
• 作者: Krishnamurthy, Venkatagiri;Paredes Spir, Isabella;Mammino, Kevin M.;Nocera, Joe R.;McGregor, Keith M.;Crosson, Bruce A.;Krishnamurthy, Lisa C.
• 通讯作者: Krishnamurthy, Lisa C.

Task-residual functional connectivity of language and attention networks.

• DOI: 10.1016/j.bandc.2018.02.003
• 发表时间: 2018-04
• 期刊: Brain and cognition
• 影响因子: 2.5
• 作者: Tran SM;McGregor KM;James GA;Gopinath K;Krishnamurthy V;Krishnamurthy LC;Crosson B
• 通讯作者: Crosson B

Spatial Neglect and Anosognosia After Right Brain Stroke.

• DOI: 10.1212/con.0000000000001076
• 发表时间: 2021-12-01
• 期刊: Continuum (Minneapolis, Minn.)
• 作者: Barrett, A M

Spatial neglect treatment: The brain's spatial-motor Aiming systems.

• DOI: 10.1080/09602011.2020.1862678
• 发表时间: 2022-06
• 期刊: Neuropsychological rehabilitation
• 影响因子: 2.7