权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Anisotropic and Nonlinear Structure-Function of Normal and Degenerate Tendon

正常肌腱和退化肌腱的各向异性和非线性结构函数

基本信息

批准号：
8035385
负责人：
DAWN M ELLIOTT
金额：
$ 29.06万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8035385
关键词：
Affect Aging Anisotropy Articular Range of Motion Athletic Attention Automobile Driving Basic Science Behavior Biochemical Collagen Fiber Complex Connective Tissue Data Disease Environment Extracellular Matrix Failure Fiber Human Image In Situ Injury Joints Knowledge Location Magnetic Resonance Imaging Measurement Measures Mechanics Methods Modality Modeling Normal tissue morphology Pain Physiological Positioning Attribute Process Property Research Research Design Role Rotator Cuff Sampling Shoulder Stretching Structure Structure-Activity Relationship Tail Tendon structure Testing Texture Tissue Engineering Tissues Transgenic Mice Workplace base design disability functional restoration improved injured innovation kinematics macromolecule mathematical model mechanical behavior novel prevent programs public health relevance repaired restoration soft tissue success supraspinatus muscle therapy design treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Rotator cuff damage due to degeneration and/or injury is a common cause of significant pain and disability affecting the young and old alike in workplace, recreational, athletic, and aging environments. Different from most tendons, the supraspinatus tendon must regularly withstand a complex loading environment including multi-axial tension, compression, and shear, which makes study of this problem difficult. The complex loading is due to its anatomical structure, with non-uniaxial forces generated by the surrounding soft tissues, the coracoacromial arch, oblique insertion angles, and non-uniform fiber orientations. In order to understand, predict, prevent, and treat supraspinatus degeneration and injury, as well as to design tissue engineered replacement structures, it is critical to develop a complete understanding of the mechanical capability of this tissue in normal and altered conditions. Therefore, the objective of this research program is to rigorously evaluate anisotropic and nonlinear structure-function relationships in normal and degenerate supraspinatus tendons. Specifically, we propose the following 2 aims: Aim 1: Quantify nonlinear and anisotropic mechanical behavior and collagen fiber re-orientation of normal and degenerated human supraspinatus tendon under multiple loading modalities including: uniaxial tension in the fiber-aligned and transverse directions, biaxial tension, and planar shear. Quantify biochemical composition and histological grade at adjacent locations to the mechanical test samples. Aim 2: Develop and apply a nonlinear anisotropic constitutive model to predict tendon structure-function relationships. Explicitly incorporate fiber distribution and fiber re-orientation under load and the contribution of fiber stretch, extrafibrillar matrix, and fiber-matrix interactions to tendon function. Determine the model parameters using the biaxial and shear experimental data from Aim 1 and validate the model by predicting the uniaxial tension data. Correlate model parameters with composition measurements to complete the structure-composition-function quantification and test hypotheses for these relationships with region and degeneration. Knowledge of these relationships will provide important information towards understanding the fundamental mechanisms driving normal tissue adaptation and aging, disease processes and potential treatments, and the design of tissue engineered replacement structures. PUBLIC HEALTH RELEVANCE: Rotator cuff damage due to degeneration and/or injury is a common cause of significant pain and disability affecting the young and old alike in workplace, recreational, athletic, and aging environments. Treatment strategies aim to restore mechanical function; however, tendon anisotropic and nonlinear mechanical behaviors are not well established. Therefore, the objective of this research program is to determine quantitative anisotropic and nonlinear structure-function relationships in normal and degenerate supraspinatus tendons.

描述（由申请人提供）：由于退化和/或损伤导致的肩袖损伤是在工作场所、娱乐、运动和老龄化环境中影响年轻人和老年人的显著疼痛和残疾的常见原因。与大多数肌腱不同，冈上肌腱必须定期承受复杂的载荷环境，包括多轴拉伸，压缩和剪切，这使得研究这个问题变得困难。复杂的载荷是由于其解剖结构，周围软组织、喙肩弓、斜插入角度和非均匀纤维方向产生的非单轴力。为了了解，预测，预防和治疗冈上肌变性和损伤，以及设计组织工程替代结构，这是至关重要的，以开发一个完整的理解，该组织在正常和改变条件下的机械能力。因此，本研究计划的目的是严格评估各向异性和非线性结构功能关系的正常和退化冈上肌腱。具体来说，我们提出了以下2个目标：目标1：量化非线性和各向异性的力学行为和胶原纤维重定向的正常和退化的人类冈上肌腱在多种加载方式下，包括：单轴拉伸纤维排列和横向方向，双轴拉伸，平面剪切。量化机械测试样品相邻位置的生化成分和组织学等级。目的2：开发和应用非线性各向异性本构模型预测肌腱的结构-功能关系。解释纳入纤维分布和纤维重定向负荷下的纤维拉伸，纤维外基质，和纤维-基质相互作用的肌腱功能的贡献。使用目标1的双轴和剪切实验数据确定模型参数，并通过预测单轴拉伸数据来验证模型。将模型参数与组成测量值相关联，以完成结构-组成-功能量化，并测试这些关系与区域和退化的假设。这些关系的知识将提供重要的信息，了解驱动正常组织适应和老化的基本机制，疾病过程和潜在的治疗，以及组织工程替代结构的设计。公共卫生关系：由于退化和/或损伤引起的肩袖损伤是在工作场所、娱乐、运动和老龄化环境中影响年轻人和老年人的显著疼痛和残疾的常见原因。治疗策略旨在恢复机械功能;然而，肌腱的各向异性和非线性力学行为尚未得到很好的建立。因此，本研究计划的目的是确定定量的各向异性和非线性结构功能关系，在正常和退化冈上肌腱。