MT VET COBRE II CORE A: ADMINISTRATIVE CORE

MT VET COBRE II 核心 A：管理核心

• 批准号: 8360158
• 负责人: MARK T QUINN
• 金额: $ 80.78万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360158
• 关键词: Academy; Accounting; Administrative Personnel; Advisory Committees; Advocate; Animal Model; Animals; Antifungal Agents; Applications Grants; Bioinformatics; Candida; Cellular biology; Centers of Research Excellence; Collaborations; Committee Members; Communicable Diseases; Communication; Complement; Computers; Consultations; Core Facility; Country; Critiques; Cryptococcus; Data; Data Reporting; Development; Educational workshop; Elements; Emerging Communicable Diseases; Evaluation; Event; Faculty; Fostering; Funding; Goals; Grant; Health; Human; Human Resources; Immunity; Individual; Infection; Infectious Disease Immunology; Infectious Diseases Research; Laboratories; Leadership; Location; Manuscripts; Mentors; Modeling; Montana; National Center for Research Resources; National Institute of Allergy and Infectious Disease; Participant; Pathogenesis; Pathology; Performance; Persons; Pilot Projects; Principal Investigator; Program Development; Progress Reports; Reading; Recommendation; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Allocation; Resources; Review Committee; Schedule; Science; Scientist; Series; Services; Source; Structure; Students; Techniques; Telephone; The science of Mycology; Travel; United States National Academy of Sciences; United States National Institutes of Health; Universities; Visit; Washington; Work; Writing; base; biosafety level 3 facility; career development; computer network; cost; data exchange; experience; improved; interest; journal article; lectures; meetings; member; pathogen; professor; programs; research facility; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Administrative Core A is directed by Dr. Mark Quinn and includes all administrative staff and Mentors. Dr. Quinn provides administrative oversight, chairs the Executive Committee, and serves as a research advocate and coordinator of the scientific research conducted under COBRE II. The purpose of the Administrative Core is to provide administrative support and services to the PI, Mentors, Project Leaders (including the Developmental Projects), Supplemental Projects, new faculty hires, and all other investigators and technical personnel associated with the Center of Zoonotic and Emerging Infectious Diseases. It is through the efforts of this Core that all projects and Cores B & C of the Center are integrated and regularly assessed. The Administrative Core also includes an Administrative and Accounting Associate who organizes the COBRE events and conferences and provides fiscal management and support for all aspects of the program, and a Program Evaluator who collects and analyzes data and reports on the progress of the programs. As PI and scientific leader of COBRE II, Dr. Quinn is responsible for all aspects of the program. As such, his primary objective is to promote close and productive scientific interaction among the component Projects, Cores, and other Center investigators. This Objective is accomplished through several mechanisms. Research seminars presented by investigators from the component Projects and investigators of the Center are scheduled monthly. The emphasis of these seminars is to present work-in-progress so the researchers in the program are kept informed of the progress of other projects on a regular basis and so that constructive input can be provided to these investigators. These seminars are scheduled monthly and rotate between the projects. Dr. Quinn also seeks to facilitate effective collaborations among the projects by personally visiting individual investigators on a regular basis. This allows for direct discussions of the ongoing needs and integration of each particular project or Core within the Center. As PI, Dr. Quinn is particularly aware that there is an optimal distribution of services of the Cores to the component Projects in terms of allocation of resources and communication of data. The Administrative Core is comprised of several additional components. The Executive Committee (EC) includes the Program Director (PD), the Core Directors, which includes Drs. Quinn, Jutila, and Pascual, and Dr. Allan Harmsen who was the previous COBRE PI. The members of the COBRE II EC also served on the COBRE I Executive Committee, thus providing continuity for the program. The COBRE II PI (Quinn) chairs the EC, which met regularly during the reporting period. The EC developed strategies with the EAC, oversaw the development of workshops and lecture series, and reviewed the progress of the projects through biannual assessment reports from the Mentoring Board. The EC reviewed Core progress reports, set priorities for resource allocation, and made recommendations to the PI for future research directions. The External Advisory Committee (EAC) advises on scientific, administrative, and research elements of the COBRE Program. The COBRE II EAC is composed of Drs. John Perfect, Frank DeLeo, Eugene Butcher, and Guy Palmer (Chair of EAC). These scientists were asked to sit on the EAC because their expertise complements the Center and because of their extensive scientific, administrative, and mentoring experience. Dr. Palmer is a Professor, Director of the Washington State University Center for Global Animal Health, and a member of the National Academy of Sciences. He also serves on the Board of Directors of the Washington State Academy of Science. Dr. Frank DeLeo is a Senior Investigator, Acting Chief for the Laboratory of Human Bacterial Pathogenesis, and Chief of the Pathogen-Host Cell Biology Section at the National Institute of Allergy and Infectious Diseases, located at the Rocky Mountain Laboratories in Hamilton, MT. Dr. Butcher is a Professor of pathology at Stanford University and an internationally recognized expert in immunity to infectious disease. Dr. Perfect is a Professor and the Director of Mycology Research Unit at Duke University. Dr. Perfect's research team investigates anti-fungal agents in animal models of Candida and Cryptococcus infections. The EAC met with the EC by phone conference once this reporting year. The EAC was also in regular contact with the EC for grant proposal reviews for the Project Leaders and consultation regarding new hires. The EAC traveled to Montana and met in person with all Project Leaders, Mentors, and Core Directors. At this meeting, the EAC provided group assessment and critiques of progress of the individual components of COBRE II, as well as progress of COBRE II as a whole. Overall, the EAC was integral in reviewing the second-year performance of COBRE II and in providing longitudinal assessment of the program and individual research projects. The EAC provided concept development, program planning, research project development and mentoring, identification of resources, and evaluation of progress toward stated goals. In some cases, EAC members provided mentoring assistance to Project Leaders for grant proposal development and identified potential national mentors and collaborators. For Core A, the EAC's review was favorable. In their September evaluation, the EAC wrote: "The administrative core and overall direction of the program continue to be outstanding. In the past year, there has been a new faculty hire (Dr. Obar) and partial support for a new bioinformatics support person. The Research-in-Progress seminar series recommended by the EAC last year has been implemented and the external speaker series continues to be successful in attracting research leaders from throughout the country. The leadership is recognized and appreciated by the Project PIs." The Administrative Core organizes several programs to enhance research experiences and publicize the MSU COBRE Program, namely the national speaker series, participation in the National IDeA Conference (NISBRE) and Regional INBRE-COBRE Conferences, oversight of the Developmental Projects Program (formerly Pilot Projects Program), and support for the Bioinformatics Facility and Research within a cross-campus and interdisciplinary collaborative model. The national speaker series brings world-class infectious disease researchers to MSU campus. The COBRE-sponsored speakers tour labs at MSU and meet with COBRE researchers and students. These visits expose all faculty and students to cutting-edge science and provide informal review of ongoing research. COBRE students and faculty prepare for the seminars by reading journal articles and background science on the speakers' research prior to their visits. The annual research conferences and symposia are important venues that allow project leaders and other important researchers to showcase their research, interact with other researchers who share similar interests, and brainstorm new techniques and ways to expand or improve the science. Starting with COBRE II, the Pilot Projects were renamed as "Developmental Projects" This aspect of the Core still serves the same function. Namely, Developmental Grants provide vital funds for projects that have been successful in developing larger, federally-funded grants and fostering career development of junior investigators. Our COBRE Center is truly a center in terms of structure and proximity of most participants in one location. Indeed, this structure is facilitated by the fact that the entire Immunology and Infectious Diseases department is involved in the Center. The laboratories and offices of all COBRE Projects, two of the three Developmental Projects, all Cores, the PI and administrative personnel, and nine of the ten Mentors are located within the same building. In addition, this department operates the COBRE BSL-3 and ABSL-2 infectious disease research facilities, which are located within half a mile of the departmental research building. The close proximity of these investigators allows daily communications between investigators and facilitates coordination of interactions between the component projects and Cores. The third Developmental Project is located at UM, and the UM investigator travels to MSU once every other month for the Project Leader-Mentor meetings held concurrently with Center seminars. In addition, this investigator has full access to the Core facilities at MSU and UM, as well as to the BSL-3 facility located at MSU. Finally, the department of Immunology and Infectious Diseases maintains a computer network that interfaces with all computers at MSU. This network allows investigators to directly communicate with each other, including the transmission of data and manuscripts. Thus, this network also facilitates rapid and seamless communication between investigators and Mentors, including those at UM and the Rocky Mountain Laboratories.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 行政核心 A 由 Mark Quinn 博士指导，包括所有行政人员和导师。 Quinn 博士负责行政监督、担任执行委员会主席，并担任 COBRE II 下开展的科学研究的研究倡导者和协调员。 行政核心的目的是为 PI、导师、项目负责人（包括发展项目）、补充项目、新聘教员以及与人畜共患病和新发传染病中心相关的所有其他研究人员和技术人员提供行政支持和服务。正是通过该核心的努力，中心的所有项目和核心 B 和 C 都得以整合并定期评估。行政核心还包括一名行政和会计助理，负责组织 COBRE 活动和会议，并为计划的各个方面提供财务管理和支持；以及一名计划评估员，负责收集和分析数据并报告计划的进展情况。 作为 COBRE II 的 PI 和科学领导者，Quinn 博士负责该项目的各个方面。因此，他的主要目标是促进项目、核心和其他中心研究人员之间密切和富有成效的科学互动。这 目标是通过多种机制实现的。每月安排一次由各项目的研究人员和中心的研究人员举办的研究研讨会。这些研讨会的重点是展示正在进行的工作，以便该项目的研究人员定期了解其他项目的进展情况，以便为这些研究人员提供建设性的意见。这些研讨会每月安排一次，并在项目之间轮流举行。奎因博士还通过定期亲自拜访个别研究人员来寻求促进项目之间的有效合作。这样可以直接讨论中心内每个特定项目或核心的持续需求和集成。作为 PI，Quinn 博士特别意识到，在资源分配和数据通信方面，核心服务到组件项目的最佳分配。 管理核心由几个附加组件组成。 执行委员会 (EC) 包括项目总监 (PD)、核心董事，其中包括 Drs. Quinn、Jutila 和 Pascual，以及前任 COBRE PI 艾伦·哈姆森 (Allan Harmsen) 博士。 COBRE II EC 的成员也在 COBRE I 执行委员会任职，从而为该计划提供了连续性。 COBRE II PI (Quinn) 担任 EC 主席，该委员会在报告期内定期举行会议。 EC 与 EAC 一起制定战略，监督研讨会和系列讲座的开展，并通过指导委员会每半年的评估报告审查项目的进展情况。 EC 审查了核心进展报告，确定了资源分配的优先顺序，并向 PI 提出了未来研究方向的建议。 外部咨询委员会 (EAC) 就 COBRE 计划的科学、管理和研究要素提供建议。 COBRE II EAC 由博士组成。 John Perfect、Frank DeLeo、Eugene Butcher 和 Guy Palmer（EAC 主席）。这些科学家被邀请加入 EAC，因为他们的专业知识与中心相辅相成，而且他们拥有丰富的科学、管理和指导经验。帕尔默博士是华盛顿州立大学全球动物健康中心的教授、主任，也是美国国家科学院院士。 他还担任华盛顿州立科学院董事会成员。 Frank DeLeo 博士是位于蒙大拿州汉密尔顿落基山实验室的国家过敏和传染病研究所的高级研究员、人类细菌发病机制实验室代理主任和病原体宿主细胞生物学科主任。布彻博士是斯坦福大学病理学教授，也是国际公认的传染病免疫专家。 Perfect 博士是杜克大学教授兼真菌学研究室主任。 Perfect 博士的研究团队在念珠菌和隐球菌感染的动物模型中研究抗真菌药物。选管会在本报告年度与欧盟委员会举行了一次电话会议。 EAC 还与 EC 定期联系，以审查项目负责人的拨款提案以及有关新员工的咨询。 EAC 前往蒙大拿州并亲自会见了所有项目负责人、导师和核心董事。在本次会议上，EAC 对 COBRE II 各个组成部分的进展以及 COBRE II 的整体进展进行了小组评估和批评。总体而言，EAC 在审查 COBRE II 第二年的绩效以及提供该计划和个别研究项目的纵向评估方面发挥了不可或缺的作用。 EAC 提供概念开发、项目规划、研究项目开发和指导、资源识别以及对既定目标进展情况的评估。 在某些情况下，EAC 成员为项目负责人提供资助提案制定的指导援助，并确定了潜在的国家导师和合作者。 对于核心 A，EAC 的审查是有利的。 EAC 在 9 月份的评估中写道：“该项目的行政核心和总体方向仍然出色。去年，聘用了新的教员（Obar 博士），并为新的生物信息学支持人员提供了部分支持。EAC 去年推荐的正在进行的研究研讨会系列已经实施，外部演讲者系列继续成功地吸引了来自全国各地的研究领导者。领导层得到了该项目的认可和赞赏。” PI。” 行政核心组织了多项计划来增强研究经验并宣传 MSU COBRE 计划，即国家演讲者系列、参加国家 IDeA 会议 (NISBRE) 和地区 INBRE-COBRE 会议、监督发展项目计划（以前的试点项目计划）以及在跨校园和跨学科合作模式下支持生物信息学设施和研究。 全国演讲系列将世界一流的传染病研究人员带到密歇根州立大学校园。 COBRE 赞助的演讲者参观了密歇根州立大学的实验室，并与 COBRE 研究人员和学生会面。 这些访问让所有教师和学生接触到尖端科学，并对正在进行的研究进行非正式回顾。 COBRE 学生和教师在访问之前阅读有关演讲者研究的期刊文章和背景科学，为研讨会做准备。 年度研究会议和研讨会是项目负责人和其他重要研究人员展示他们的研究、与具有相似兴趣的其他研究人员互动以及集思广益扩展或改进科学的新技术和方法的重要场所。 从 COBRE II 开始，试点项目被重命名为“开发项目”。核心的这一方面仍然具有相同的功能。 也就是说，发展补助金为那些成功开发更大的联邦资助补助金和促进初级研究人员职业发展的项目提供重要资金。 我们的 COBRE 中心在结构和邻近性方面确实是一个中心，大多数参与者都集中在一个地点。事实上，整个免疫学和传染病部门都参与该中心这一事实促进了这种结构。所有 COBRE 项目的实验室和办公室、三个开发项目中的两个、所有核心、PI 和管理人员以及十名导师中的九名都位于同一栋大楼内。此外，该部门还运营着 COBRE BSL-3 和 ABSL-2 传染病研究设施，这些设施位于该部门研究大楼半英里范围内。这些调查人员距离很近，允许调查人员之间进行日常沟通，并促进组成项目和核心之间互动的协调。第三个发展项目位于 UM，UM 调查员每隔一个月前往 MSU 一次，参加与中心研讨会同时举行的项目负责人-导师会议。此外，该调查员可以完全访问 MSU 和 UM 的核心设施以及位于 MSU 的 BSL-3 设施。最后，免疫学和传染病系维护着一个与密歇根州立大学所有计算机连接的计算机网络。该网络允许调查人员直接相互沟通，包括数据和手稿的传输。因此，该网络还促进了研究人员和导师（包括密歇根大学和落基山实验室的导师）之间的快速、无缝沟通。