Center for Zoonotic and Emerging Infectious Diseases

人畜共患病和新发传染病中心

• 批准号: 8874236
• 负责人: MARK T QUINN
• 金额: $ 108万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8874236
• 关键词: Center; Zoonotic; Emerging; Infectious; Diseases

DESCRIPTION (provided by applicant): Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent human contact. To address the growing need for infectious disease research, a COBRE Center of Excellence was established at MSU, with the goal of positioning Montana as a national leader in research on zoonotic infectious diseases. Over the past 9 years, the Center has been extremely successful, resulting in infrastructure development (facilities & equipment), recruitment and support of junior investigators (7 COBRE Projects, 6 new hires, and 20 Pilot Projects), and formation of a cohesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for infectious disease research in the region. Importantly, these efforts have fostered faculty career development and have created a pipeline of new researchers with interest and expertise in infectious disease pathogenesis. With this solid infrastructure foundation in place, we are now ideally poised for Center transition to a sustainable research enterprise. Our long term goal is to maintain a sustainable Center of Excellence that is focused on understanding the mechanisms of pathogenesis, host immune response, and immunotherapeutic development for zoonotic and emerging infectious diseases of regional and worldwide importance. The primary goal of COBRE III is to facilitate transition of the Center into a sustainable entity with state-of-the-art research core facilities and a vibrant research environment. Through COBRE III efforts, we also seek to maintain and enhance the critical mass of investigators needed to support future program initiatives. While the foundation and infrastructure for achieving these goals have been established during COBRE l/ll, there is still a critical need for infrastructure optimization and acquisition of additional researchers in he area of infectious diseases to enrich the group and facilitate programmatic efforts. The transition to Center sustainability will be stimulated by an enhanced Pilot Grants Program that will expand the scope and impact of Center research and increase the number of collaborative efforts leading toward larger program-type grants. Likewise, the transition to Center sustainability will involve solidfying scientific Core structure and optimizing utilization of Core research facilities/resources. Finally, Center transition will be enhanced by career development initiatives such as educational programs and mentoring activities, to meet the needs of all Center associated investigators. Importantly, this Center will continue to be highly interactive and collaborative and will play an important role in expanding the infectious disease research enterprise in Montana.

描述（由申请方提供）：人畜共患病和新发传染病对全球健康构成日益严重的真实的威胁，由于人口密度增加、家畜种群暴露增加以及野生动物拥挤在人类频繁接触的有限区域，因此我们必须扩大对这些疾病的发病机制和预防的了解。为了满足对传染病研究日益增长的需求，在密歇根州立大学建立了COBRE卓越中心，目标是将蒙大拿州定位为人畜共患传染病研究的国家领导者。在过去的9年里，该中心取得了极大的成功，导致基础设施的发展（设施和设备），招聘和支持初级调查员（7个COBRE项目，6个新员工和20个试点项目），并形成了一个有凝聚力的调查员中心。这些组成部分的协同作用为该区域的传染病研究奠定了坚实的基础。重要的是，这些努力促进了教师的职业发展，并创造了一个新的研究人员与传染病发病机制的兴趣和专业知识的管道。有了这个坚实的基础设施基础，我们现在已经做好了从中心过渡到可持续研究企业的理想准备。我们的长期目标是保持一个可持续的卓越中心，专注于了解区域和全球重要的人畜共患病和新发传染病的发病机制，宿主免疫反应和免疫发展。COBRE III的主要目标是促进中心转变为一个可持续的实体，拥有最先进的研究核心设施和充满活力的研究环境。通过COBRE III的努力，我们还寻求维持和加强支持未来计划举措所需的调查人员的临界质量。虽然在COBRE I/II期间已经建立了实现这些目标的基础和基础设施，但仍然迫切需要优化基础设施并在传染病领域获得更多的研究人员，以丰富该小组并促进方案工作。过渡 中心的可持续性将通过一个增强的试点赠款计划来刺激，该计划将扩大中心研究的范围和影响，并增加合作努力的数量，从而获得更大的计划类型的赠款。同样，向中心可持续发展的过渡将涉及巩固科学核心结构和优化核心研究设施/资源的利用。最后，将通过职业发展计划（如教育计划和指导活动）来加强中心过渡，以满足所有中心相关研究者的需求。重要的是，该中心将继续保持高度互动和协作，并将在扩大蒙大拿州传染病研究事业方面发挥重要作用。