Center for Zoonotic and Emerging Infectious Diseases

人畜共患病和新发传染病中心

• 批准号: 8089421
• 负责人: MARK T QUINN
• 金额: $ 209.43万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-29 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089421
• 关键词: Center; Zoonotic; Emerging; Infectious; Diseases

DESCRIPTION (provided by applicant): Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent human contact. To address the need for infectious disease research capabilities, a COBRE Center of Excellence was established at Montana State University (MSU), with the goal of positioning Montana as a national leader in research on the pathogenesis of zoonotic infectious diseases. Over the past four years, the Center has been extremely successful, resulting in development of infrastructure, recruitment and support of junior investigators, and formation of a cohesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for expansion of infectious disease research in the region. With this infrastructure in place, we are now ideally poised to expand and strengthen the Center as a scalable and sustainable research enterprise. Our long term goal is to establish a sustainable Center of Excellence that is focused on understanding pathogenesis, host immune responses, and therapeutic development for zoonotic and emerging infectious diseases of regional and worldwide importance. While the foundation for this goal has been established through accomplishments realized during COBRE I, there is still a critical need for further faculty development, infrastructure enhancement, and recruitment of additional researchers in the area of zoonotic and emerging infectious diseases, and three specific aims are proposed to address these needs. First, we propose a pipeline to foster the development of current junior investigators so that funding and infrastructure resources are available at critical junctures in their careers. Secondly, we propose to increase the size, scope, and competitiveness of the Center through four new faculty hires. Together, accomplishment of these two aims will lead to establishment of the critical mass of investigators needed to sustain the Center and support future infectious disease research initiatives. Finally, we propose to strengthen the infectious disease research infrastructure in Montana through support and enhancement of established COBRE core facilities. Because of the success of COBRE I, the proven scientific abilities of the Center investigators, the outstanding institutional support, and the emphasis on a timely and increasingly important area of research, we believe that COBRE II support will lead to completion of a scalable and sustainable Center of Excellence in zoonotic and emerging infectious disease research. PUBLIC HEALTH RELEVANCE (provided by applicant): Many of the important and emerging Infectious diseases of humans are zoonotic, and most are also potential weapons of bioterrorism. Furthermore, a number of these diseases have reservoirs in the livestock and wildlife of our nation. COBRE II will strengthen and enrich our Center of Excellence in infectious disease research, providing the resources needed to advance our understanding of disease pathogenesis and facilitating development of novel therapeutic treatments.

描述（由申请方提供）：人畜共患病和新发传染病对全球健康构成日益严重的真实的威胁，由于人口密度增加、家畜种群暴露增加以及野生动物拥挤在人类频繁接触的有限区域，因此我们必须扩大对这些疾病的发病机制和预防的了解。为了满足对传染病研究能力的需求，在蒙大拿州立大学（MSU）建立了COBRE卓越中心，目标是将蒙大拿州定位为人畜共患传染病发病机制研究的国家领导者。在过去四年中，该中心取得了极大的成功，发展了基础设施，征聘和支持了初级调查员，并形成了一个有凝聚力的调查员中心。这些组成部分的协同作用为扩大该区域的传染病研究奠定了坚实的基础。有了这个基础设施，我们现在已经准备好扩大和加强中心作为一个可扩展的和可持续的研究企业。 我们的长期目标是建立一个可持续发展的卓越中心，专注于了解发病机制，宿主免疫反应，以及对区域和全球重要的人畜共患病和新发传染病的治疗开发。虽然这一目标的基础已经通过COBRE I期间实现的成就建立，但仍然迫切需要进一步发展教师队伍，加强基础设施，并在人畜共患病和新发传染病领域招募更多的研究人员，并提出了三个具体目标来满足这些需求。首先，我们提出了一个管道，以促进当前初级调查员的发展，以便在他们职业生涯的关键时刻获得资金和基础设施资源。其次，我们建议通过四名新教师的聘用来增加中心的规模，范围和竞争力。这两个目标的共同实现将导致建立维持中心和支持未来传染病研究计划所需的研究人员的临界质量。最后，我们建议通过支持和加强已建立的COBRE核心设施来加强蒙大拿州的传染病研究基础设施。由于COBRE I的成功，中心研究人员的科学能力，出色的机构支持，以及对及时和日益重要的研究领域的重视，我们相信COBRE II的支持将导致在人畜共患病和新兴传染病研究方面完成可扩展和可持续的卓越中心。 公共卫生相关性（由申请人提供）：许多重要的和新出现的人类传染病是人畜共患病，大多数也是生物恐怖主义的潜在武器。此外，其中一些疾病在我国的牲畜和野生动物中有宿主。COBRE II将加强和丰富我们在传染病研究方面的卓越中心，提供所需的资源，以促进我们对疾病发病机制的理解，并促进新型治疗方法的开发。

项目成果

Oral Escherichia coli colonization factor antigen I fimbriae ameliorate arthritis via IL-35, not IL-27.

• DOI: 10.4049/jimmunol.1302018
• 发表时间: 2014-01-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Kochetkova I;Thornburg T;Callis G;Holderness K;Maddaloni M;Pascual DW
• 通讯作者: Pascual DW

Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita.

• DOI: 10.1016/j.phytochem.2008.01.009
• 发表时间: 2008-04
• 期刊: Phytochemistry
• 影响因子: 3.8
• 作者: G. Xie;I. Schepetkin;D. Siemsen;Liliya N. Kirpotina;J. Wiley;M. Quinn

IgG Endopeptidase SeMac does not Inhibit Opsonophagocytosis of Streptococcus equi Subspecies equi by Horse Polymorphonuclear Leukocytes.

• DOI: 10.2174/1874285801004010020
• 发表时间: 2010-04-08
• 期刊: The open microbiology journal
• 作者: Liu M;Lei B
• 通讯作者: Lei B

Interactome for auxiliary splicing factor U2AF(65) suggests diverse roles.

辅助剪接因子U2AF（65）的互动组提出了各种作用。

• DOI: 10.1016/j.bbagrm.2009.06.002
• 发表时间: 2009-06
• 期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
• 影响因子: 4.7
• 作者: Prigge, Justin R.;Iverson, Sonya V.;Siders, Ashley M.;Schmidt, Edward E.
• 通讯作者: Schmidt, Edward E.

Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.

• DOI: 10.1111/j.1365-2958.2010.07254.x
• 发表时间: 2010-08
• 期刊: Molecular microbiology
• 影响因子: 3.6
• 作者: Puttikamonkul S;Willger SD;Grahl N;Perfect JR;Movahed N;Bothner B;Park S;Paderu P;Perlin DS;Cramer RA Jr
• 通讯作者: Cramer RA Jr