Center for Zoonotic and Emerging Infectious Diseases

人畜共患病和新发传染病中心

• 批准号: 9100428
• 负责人: MARK T QUINN
• 金额: $ 108万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9100428
• 关键词: Address; Area; Bioterrorism; Centers of Research Excellence; Communicable Diseases; Core Facility; Crowding; Development; Disease; Domestic Animals; Emerging Communicable Diseases; Environment; Equipment; Exposure to; Faculty; Fostering; Foundations; Future; Goals; Grant; Human; Immune response; Immunotherapeutic agent; Infectious Diseases Research; Mentors; Montana; Pathogenesis; Pilot Projects; Play; Population; Positioning Attribute; Research; Research Infrastructure; Research Personnel; Resources; Role; Solid; Structure; career development; density; disorder prevention; global health; infrastructure development; interest; meetings; novel therapeutics; programs; research facility; synergism; weapons

Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent human contact. To address the growing need for infectious disease research, a COBRE Center of Excellence was established at MSU, with the goal of positioning Montana as a national leader in research on zoonotic infectious diseases. Over the past 9 years, the Center has been extremely successful, resulting in infrastructure development (facilities & equipment), recruitment and support of junior investigators (7 COBRE Projects, 6 new hires, and 20 Pilot Projects), and formation of a cohesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for infectious disease research in the region. Importantly, these efforts have fostered faculty career development and have created a pipeline of new researchers with interest and expertise in infectious disease pathogenesis. With this solid infrastructure foundation in place, we are now ideally poised for Center transition to a sustainable research enterprise. Our long term goal is to maintain a sustainable Center of Excellence that is focused on understanding the mechanisms of pathogenesis, host immune response, and immunotherapeutic development for zoonotic and emerging infectious diseases of regional and worldwide importance. The primary goal of COBRE III is to facilitate transition of the Center into a sustainable entity with state-of-the-art research core facilities and a vibrant research environment. Through COBRE III efforts, we also seek to maintain and enhance the critical mass of investigators needed to support future program initiatives. While the foundation and infrastructure for achieving these goals have been established during COBRE l/ll, there is still a critical need for infrastructure optimization and acquisition of additional researchers in the area of infectious diseases to enrich the group and facilitate programmatic efforts. The transition to Center sustainability will be stimulated by an enhanced Pilot Grants Program that will expand the scope and impact of Center research and increase the number of collaborative efforts leading toward larger program-type grants. Likewise, the transition to Center sustainability will involve solidfying scientific Core structure and optimizing utilization of Core research facilities/resources. Finally, Center transition will be enhanced by career development initiatives, such as educational programs and mentoring activities, to meet the needs of all Center-associated investigators. Importantly, this Center will continue to be highly interactive and collaborative and will play an important role in expanding the infectious disease research enterprise in Montana.

动物和新兴的传染病代表着对全球的越来越多的威胁 健康，至关重要的是，我们必须扩大对这些发病机理和预防的理解 疾病由于人口密度的增加，对国内的暴露量增加 动物种群，野生动植物频繁接触到有限的地区。解决 对传染病研究的需求日益增长，在MSU建立了一个鞋布的卓越中心 目的是将蒙大拿州定位为人畜共患性传染病研究的国家领导者。超过 在过去的9年中，该中心非常成功，导致基础设施开发 （设施和设备），初级调查人员的招聘和支持（7个工土项目，6名新员工，以及 20个试点项目），并形成了一个凝聚力的研究人员。这些组件的协同作用 导致在该地区建立了为传染病研究建立坚实的基础。 重要的是，这些努力促进了教师职业发展，并创建了新的 具有感兴趣和专业知识的研究人员在传染病发病机理中。使用这种扎实的基础设施 基金会到位，我们现在已经准备好向中心过渡到可持续研究企业。 我们的长期目标是维持可持续的卓越中心，该中心专注于理解 人畜共患病发病机理，宿主免疫反应和免疫治疗发育的机制 以及新兴的区域和全球重要性传染病。索贝尔三世的主要目标是 促进中心向具有最先进的研究核心设施的可持续实体过渡和 充满活力的研究环境。通过Cobre III的努力，我们还寻求维护和增强 需要支持未来计划计划的调查人员的关键质量。而基金会和 实现这些目标的基础架构是在cobre l/ll期间建立的，仍然有一个急需的需求 为了优化基础设施，并获得传染病领域的其他研究人员 丰富了小组并促进编程工作。向中心可持续性的过渡将受到刺激 通过增强的试点赠款计划，该计划将扩大中心研究的范围和影响 增加导致更大计划型赠款的协作努力数量。同样， 过渡到中心可持续性将涉及固定科学核心结构并优化利用 核心研究设施/资源。最后，职业发展将增强中心过渡 诸如教育计划和指导活动之类的举措，以满足所有中心相关的需求 调查人员。重要的是，该中心将继续具有高度互动性和协作性，并且 将在扩大蒙大拿州的传染病研究企业中发挥重要作用。