Center for Zoonotic and Emerging Infectious Diseases

人畜共患病和新发传染病中心

• 批准号: 9100428
• 负责人: MARK T QUINN
• 金额: $ 108万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9100428
• 关键词: Address; Area; Bioterrorism; Centers of Research Excellence; Communicable Diseases; Core Facility; Crowding; Development; Disease; Domestic Animals; Emerging Communicable Diseases; Environment; Equipment; Exposure to; Faculty; Fostering; Foundations; Future; Goals; Grant; Human; Immune response; Immunotherapeutic agent; Infectious Diseases Research; Mentors; Montana; Pathogenesis; Pilot Projects; Play; Population; Positioning Attribute; Research; Research Infrastructure; Research Personnel; Resources; Role; Solid; Structure; career development; density; disorder prevention; global health; infrastructure development; interest; meetings; novel therapeutics; programs; research facility; synergism; weapons

Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent human contact. To address the growing need for infectious disease research, a COBRE Center of Excellence was established at MSU, with the goal of positioning Montana as a national leader in research on zoonotic infectious diseases. Over the past 9 years, the Center has been extremely successful, resulting in infrastructure development (facilities & equipment), recruitment and support of junior investigators (7 COBRE Projects, 6 new hires, and 20 Pilot Projects), and formation of a cohesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for infectious disease research in the region. Importantly, these efforts have fostered faculty career development and have created a pipeline of new researchers with interest and expertise in infectious disease pathogenesis. With this solid infrastructure foundation in place, we are now ideally poised for Center transition to a sustainable research enterprise. Our long term goal is to maintain a sustainable Center of Excellence that is focused on understanding the mechanisms of pathogenesis, host immune response, and immunotherapeutic development for zoonotic and emerging infectious diseases of regional and worldwide importance. The primary goal of COBRE III is to facilitate transition of the Center into a sustainable entity with state-of-the-art research core facilities and a vibrant research environment. Through COBRE III efforts, we also seek to maintain and enhance the critical mass of investigators needed to support future program initiatives. While the foundation and infrastructure for achieving these goals have been established during COBRE l/ll, there is still a critical need for infrastructure optimization and acquisition of additional researchers in the area of infectious diseases to enrich the group and facilitate programmatic efforts. The transition to Center sustainability will be stimulated by an enhanced Pilot Grants Program that will expand the scope and impact of Center research and increase the number of collaborative efforts leading toward larger program-type grants. Likewise, the transition to Center sustainability will involve solidfying scientific Core structure and optimizing utilization of Core research facilities/resources. Finally, Center transition will be enhanced by career development initiatives, such as educational programs and mentoring activities, to meet the needs of all Center-associated investigators. Importantly, this Center will continue to be highly interactive and collaborative and will play an important role in expanding the infectious disease research enterprise in Montana.

人畜共患传染病和新出现的传染病对全球 健康，我们必须扩大对这些疾病的发病机制和预防的了解 疾病，因为人口密度的增加，家庭接触的增加 动物种群，以及野生动物挤入人类频繁接触的有限区域。致信地址 由于对传染病研究的需求日益增长，密歇根州立大学成立了科布雷卓越中心， 目标是将蒙大拿州定位为人畜共患传染病研究的全国领先者。完毕 在过去的9年里，该中心取得了极大的成功，导致了基础设施的发展 (设施和设备)、征聘和支助初级调查员(7个科布雷项目、6名新雇用人员和 20个试点项目)，并成立了一个调查人员凝聚力中心。这些组件的协同作用 为该区域的传染病研究奠定了坚实的基础。 重要的是，这些努力促进了教师的职业发展，并创造了一条新的管道 对传染病发病机制有兴趣和专业知识的研究人员。有了这个坚实的基础设施 随着基础的建立，我们现在为中心向可持续发展的研究企业转型做好了理想的准备。 我们的长期目标是保持一个可持续的卓越中心，专注于理解 人畜共患病的发病机制、宿主免疫反应及免疫治疗进展 和新出现的具有区域和世界重要性的传染病。科布雷III的首要目标是 促进中心转变为一个可持续的实体，拥有最先进的研究核心设施和 充满活力的研究环境。通过Cobre III的努力，我们还寻求保持和加强 需要大量的调查人员来支持未来的项目倡议。虽然基金会和 实现这些目标的基础设施已在L科布雷期间建立，但仍有迫切需要 基础设施优化和获得传染病领域的更多研究人员，以 丰富群体，促进方案工作。向中心可持续性的过渡将受到刺激 通过增强的试点拨款计划，扩大中心研究和影响的范围和影响 增加合作努力的数量，从而获得更大规模的计划类型的赠款。同样， 向中心可持续性过渡将涉及巩固科学的核心结构和优化利用 核心研究设施/资源。最后，职业发展将促进中锋过渡。 计划，如教育计划和指导活动，以满足所有与中心相关的需求 调查人员。重要的是，该中心将继续保持高度互动性和协作性， 将在扩大蒙大拿州的传染病研究事业方面发挥重要作用。