Center for Zoonotic and Emerging Infectious Diseases

动物传染病和新出现的传染病对全球环境构成日益严重的真实的威胁， 我们必须扩大对这些疾病的发病机制和预防的了解， 由于人口密度的增加， 动物种群，以及野生动物拥挤到人类频繁接触的有限区域。解决 随着对传染病研究需求的不断增长，在密歇根州立大学建立了COBRE卓越中心， 目标是将蒙大拿州定位为动物传染病研究的国家领导者。超过 在过去的9年里，该中心取得了极大的成功，基础设施的发展， （设施和设备），招聘和支持初级调查员（7个COBRE项目，6名新雇员， 20个试点项目），并成立一个有凝聚力的调查中心。这些成分的协同作用 为该地区的传染病研究奠定了坚实的基础。 重要的是，这些努力促进了教师的职业发展，并创造了一个新的管道 对传染病发病机理感兴趣并具有专业知识的研究人员。有了这个坚实的基础设施 随着基础的建立，我们现在已经为中心向可持续研究企业的过渡做好了理想的准备。 我们的长期目标是保持一个可持续的卓越中心，专注于了解 人畜共患病的发病机制、宿主免疫应答和免疫发育 和新出现的具有区域和全球重要性的传染病。COBRE III的主要目标是 促进中心转变为一个可持续发展的实体，拥有最先进的研究核心设施， 充满活力的研究环境。通过COBRE III的努力，我们还寻求维持和加强 研究人员的临界质量需要支持未来的计划举措。虽然基金会和 在COBRE I/II期间已经建立了实现这些目标的基础设施，但仍然迫切需要 用于基础设施优化和获取传染病领域的更多研究人员， 丰富工作组并促进方案工作。将促进向中心可持续性的过渡 通过一个增强的试点赠款计划，将扩大中心研究的范围和影响， 增加合作努力的数量，以获得更大的方案类型赠款。同样， 向中心可持续性过渡将涉及巩固科学核心结构和优化利用 核心研究设施/资源。最后，通过职业发展促进中心转型 计划，如教育计划和指导活动，以满足所有中心相关的需求 investigators.重要的是，该中心将继续高度互动和协作， 将在扩大蒙大拿州的传染病研究事业中发挥重要作用。

Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent human contact. To address the growing need for infectious disease research, a COBRE Center of Excellence was established at MSU, with the goal of positioning Montana as a national leader in research on zoonotic infectious diseases. Over the past 9 years, the Center has been extremely successful, resulting in infrastructure development (facilities & equipment), recruitment and support of junior investigators (7 COBRE Projects, 6 new hires, and 20 Pilot Projects), and formation of a cohesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for infectious disease research in the region. Importantly, these efforts have fostered faculty career development and have created a pipeline of new researchers with interest and expertise in infectious disease pathogenesis. With this solid infrastructure foundation in place, we are now ideally poised for Center transition to a sustainable research enterprise. Our long term goal is to maintain a sustainable Center of Excellence that is focused on understanding the mechanisms of pathogenesis, host immune response, and immunotherapeutic development for zoonotic and emerging infectious diseases of regional and worldwide importance. The primary goal of COBRE III is to facilitate transition of the Center into a sustainable entity with state-of-the-art research core facilities and a vibrant research environment. Through COBRE III efforts, we also seek to maintain and enhance the critical mass of investigators needed to support future program initiatives. While the foundation and infrastructure for achieving these goals have been established during COBRE l/ll, there is still a critical need for infrastructure optimization and acquisition of additional researchers in the area of infectious diseases to enrich the group and facilitate programmatic efforts. The transition to Center sustainability will be stimulated by an enhanced Pilot Grants Program that will expand the scope and impact of Center research and increase the number of collaborative efforts leading toward larger program-type grants. Likewise, the transition to Center sustainability will involve solidfying scientific Core structure and optimizing utilization of Core research facilities/resources. Finally, Center transition will be enhanced by career development initiatives, such as educational programs and mentoring activities, to meet the needs of all Center-associated investigators. Importantly, this Center will continue to be highly interactive and collaborative and will play an important role in expanding the infectious disease research enterprise in Montana.