Center for Zoonotic and Emerging Infectious Diseases

人畜共患病和新发传染病中心

• 批准号: 8705651
• 负责人: MARK T QUINN
• 金额: $ 108万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8705651
• 关键词: Address; Area; Bioterrorism; Centers of Research Excellence; Communicable Diseases; Core Facility; Crowding; Development; Disease; Domestic Animals; Emerging Communicable Diseases; Environment; Equipment; Exposure to; Faculty; Fostering; Foundations; Future; Goals; Grant; Human; Immune response; Immunotherapeutic agent; Infectious Diseases Research; Mentors; Montana; Pathogenesis; Pilot Projects; Play; Population; Population Density; Positioning Attribute; Research; Research Infrastructure; Research Personnel; Resources; Role; Solid; Structure; career development; disorder prevention; global health; infrastructure development; interest; meetings; novel therapeutics; programs; public health relevance; research facility; synergism; weapons

DESCRIPTION (provided by applicant): Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent human contact. To address the growing need for infectious disease research, a COBRE Center of Excellence was established at MSU, with the goal of positioning Montana as a national leader in research on zoonotic infectious diseases. Over the past 9 years, the Center has been extremely successful, resulting in infrastructure development (facilities & equipment), recruitment and support of junior investigators (7 COBRE Projects, 6 new hires, and 20 Pilot Projects), and formation of a cohesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for infectious disease research in the region. Importantly, these efforts have fostered faculty career development and have created a pipeline of new researchers with interest and expertise in infectious disease pathogenesis. With this solid infrastructure foundation in place, we are now ideally poised for Center transition to a sustainable research enterprise. Our long term goal is to maintain a sustainable Center of Excellence that is focused on understanding the mechanisms of pathogenesis, host immune response, and immunotherapeutic development for zoonotic and emerging infectious diseases of regional and worldwide importance. The primary goal of COBRE III is to facilitate transition of the Center into a sustainable entity with state-of-the-art research core facilities and a vibrant research environment. Through COBRE III efforts, we also seek to maintain and enhance the critical mass of investigators needed to support future program initiatives. While the foundation and infrastructure for achieving these goals have been established during COBRE l/ll, there is still a critical need for infrastructure optimization and acquisition of additional researchers in he area of infectious diseases to enrich the group and facilitate programmatic efforts. The transition to Center sustainability will be stimulated by an enhanced Pilot Grants Program that will expand the scope and impact of Center research and increase the number of collaborative efforts leading toward larger program-type grants. Likewise, the transition to Center sustainability will involve solidfying scientific Core structure and optimizing utilization of Core research facilities/resources. Finally, Center transition will be enhanced by career development initiatives such as educational programs and mentoring activities, to meet the needs of all Center associated investigators. Importantly, this Center will continue to be highly interactive and collaborative and will play an important role in expanding the infectious disease research enterprise in Montana.

描述（由申请人提供）：人畜共患病和新兴的传染病代表着对全球健康的日益增加和非常实际的威胁，至关重要的是，我们必须扩大人们对这些疾病的发病机理和预防人群密度的理解，因为人类人群的密度增加，对家养动物种群的暴露越来越大，以及对野生动物频繁的人类接触的群体拥挤。为了满足对传染病研究的日益增长的需求，在MSU建立了一个鞋底卓越中心，其目的是将蒙大拿州定位为人畜共患性传染病研究的国家领导者。在过去的9年中，该中心非常成功，导致基础设施开发（设施和设备），初级调查人员的招聘和支持（7个牢房项目，6名新员工和20个试点项目），以及组建一个凝聚力的调查人员中心。这些组成部分的协同作用导致在该地区建立了为传染病研究建立了坚实的基础。重要的是，这些努力促进了教师的职业发展，并创建了一条新的研究人员，这些研究人员对传染病发病机理有兴趣和专业知识。有了这个稳定的基础设施基金会，我们现在可以理想地进行中心过渡到可持续的研究企业。我们的长期目标是保持一个可持续的卓越中心，该中心侧重于理解发病机理的机制，宿主免疫反应以及对人畜共动性和新兴的地区和全球重要性的传染病的免疫治疗发展。 Cobre III的主要目标是促进中心向具有最先进的研究核心设施和充满活力的研究环境的中心过渡到可持续的实体。通过Cobre III的努力，我们还寻求维护和增强支持未来计划计划所需的关键调查人员。尽管在Cobre l/ll期间已经建立了实现这些目标的基础和基础设施，但仍然需要在传染病领域优化基础设施优化和收购其他研究人员，以丰富该小组并促进程序化努力。过渡 提高的试点赠款计划将刺激可持续性，该计划将扩大中心研究的范围和影响，并增加为更大的计划型赠款提供的协作努力的数量。同样，向中心可持续性的过渡将涉及固定科学核心结构并优化核心研究设施/资源的利用。最后，在职业发展计划（例如教育计划和指导活动）中，将增强中心过渡，以满足所有中心相关研究人员的需求。重要的是，该中心将继续具有高度互动性和协作性，并将在扩大蒙大拿州的传染病研究企业中发挥重要作用。