MT VET COBRE CORE A: ADMINISTRATIVE CORE

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 蒙大拿州立大学 (MSU) COBRE 行政核心在报告年度更换了项目主管。马克·奎因 (Mark Quinn) 博士接替艾伦·哈姆森 (Allen Harmsen) 博士。奎因博士的研究重点是了解先天免疫细胞用于保护宿主免受病原体侵害的杀菌机制。 具体项目正在进行中，以研究吞噬细胞氧自由基产生的分子和生化基础，以及吞噬细胞产生的氧化剂在人类和动物炎症性疾病相关组织损伤中的作用。 其他工作重点是识别和表征用于增强先天免疫反应的新型免疫调节剂。 Quinn 博士发表了 120 多篇同行评审文章，目前担任兽医分子生物学系主任。 奎因博士的职责与哈姆森博士相同。具体来说，Quinn 博士提供行政监督、担任执行委员会主席，并担任 MSU COBRE 下开展的科学研究的研究倡导者和协调员。 该核心的目的是为项目负责人 (PL)、核心主任、研究导师、新聘教员以及从事拟议中心的科学项目和核心的所有研究人员和技术人员提供行政支持和服务。奎因博士直接与项目导师合作，指导和协调项目项目和新教师的聘用，正是通过这个核心，中心的项目和相关核心将相互交织并定期评估。在这一监督下，Quinn 博士负责领导、管理、人员配备和资源分配，并根据 NIH 政策管理 MSU COBRE。行政核心还包括一名行政和会计助理，负责组织 COBRE 活动和会议，并为项目的各个方面提供财务管理和支持；以及一名项目评估员，负责收集和分析数据并报告项目进展情况。 管理核心由几个附加组件组成。执行委员会（EC）包括项目总监（PD）和核心董事。该中心的核心成员包括基因组学和蛋白质组学核心（核心 B）、分子和细胞分析核心（核心 C）和 BSL-3 核心（核心 D）的主任。每个 COBRE 核心的主任都是兽医分子生物学教师，并且也是指导委员会的成员。总体而言，EC 将审查 COBRE 进度报告，确定计划项目研究工作的优先顺序，为所有核心活动提供指导，并向 PD 提出未来中心方向的建议。 外部咨询委员会 (EAC) 就 COBRE 计划的科学、管理和研究要素提供建议。 EAC 审查 MSU COBRE 的绩效、具体目标，并评估该计划和单个研究项目的纵向进展。 EAC 活动包括概念开发、项目规划、研究项目开发和指导、资源识别以及对既定目标进展情况的评估。在某些情况下，EAC 成员为项目负责人提供指导帮助，并确定潜在的国家导师和合作者。该委员会由国家认可的科学家组成，其中包括：约翰·科利尔 (John Collier)，哈佛大学、美国国家科学院院士、国际公认的炭疽毒素专家； Jerry McGhee，阿拉巴马大学伯明翰分校，国际知名粘膜免疫专家；华盛顿大学免疫学系主任、国际公认的传染病免疫专家克里斯托弗·威尔逊（Christopher Wilson）。在 2007-2008 年报告期间，Suzy Swain 博士因其研究项目的外部义务而要求离开 EAC。核心得以招募 John R. Perfect 博士代替她在 EAC 任职。这一变化是有益的，因为大多数新员工都专注于细菌和真菌发病机制，而这不是 Swain 博士的专长。 Perfect 博士凭借其专业知识，对研究重点的这一转变提供了全面的监督。 Perfect 博士是杜克大学真菌学研究室主任。 Perfect 博士的研究团队在念珠菌和隐球菌感染的动物模型中研究抗真菌药物。 行政核心组织了多项计划来增强研究经验并宣传 MSU COBRE 计划，即全国演讲者系列、年度研究会议、小额赠款计划的监督以及在跨校园和跨学科合作模式下对生物信息学设施和研究的支持。全国演讲系列将世界一流的传染病研究人员带到密歇根州立大学校园。 COBRE 赞助的演讲者参观了密歇根州立大学的实验室，并与 COBRE 研究人员和学生会面。这些访问让所有教师和学生接触到尖端科学，并对正在进行的研究进行非正式回顾。 COBRE 学生和教师在访问之前阅读有关演讲者研究的期刊文章和背景科学，为研讨会做准备。年度研究会议和研讨会是项目负责人和其他重要研究人员展示他们的研究、与具有相似兴趣的其他研究人员互动以及集思广益扩展或改进科学的新技术和方法的重要场所。小额赠款计划为已成功开发更大规模的联邦资助赠款的试点项目提供重要资金。对生物信息学的支持对于 COBRE 至关重要，对于密歇根州立大学的研究人员和学生也至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Montana State University (MSU) COBRE Administrative Core changed Program Directors during the reporting year. Dr. Mark Quinn took over for Dr. Allen Harmsen. Dr. Quinn's research is focused on understanding microbicidal mechanisms utilized by innate immune cells in defense of the host against pathogens. Specific projects are in progress to investigate the molecular & biochemical basis of phagocyte oxygen radical production, as well as the role of phagocyte-generated oxidants in tissue damage associated with inflammatory diseases in humans and animals. Additional work focuses on identifying and characterizing novel immunomodulatory agents for enhancing innate immune responses. Dr. Quinn has published over 120 peer-reviewed articles and is currently Head of the Department of Veterinary Molecular Biology. Dr. Quinn functions in the same capacities as did Dr. Harmsen. Specifically, Dr. Quinn provides administrative oversight, chairs the Executive Committee, and serves as a research advocate and coordinator of the scientific research conducted under MSU COBRE. The purpose of this core is to provide administrative support and services to the Project Leaders (PLs), Core Directors, Research Mentors, new faculty hires, and to all investigators and technical personnel working on the scientific projects and cores of the proposed center. Dr. Quinn works directly with the project mentors to guide and coordinate the program projects and new faculty hires, and it is through this Core that the projects and related cores of the center will be interwoven and regularly assessed. Under this oversight, Dr. Quinn is responsible for the leadership, management, staffing, and resource allocation, and for administering the MSU COBRE in accordance with NIH policies. The Administrative Core also includes an Administrative and Accounting Associate who organizes the COBRE events and conferences and provides fiscal management and support for all aspects of the program and a Program Evaluator who collects and analyzes data and reports on the progress of the programs. The Administrative Core is comprised of several additional components. The Executive Committee (EC) includes the Program Director (PD) and the Core Directors. The Cores of the Center include directors from the Genomics and Proteomics Core (Core B), Molecular and Cellular Analysis Core (Core C), and BSL-3 Core (Core D). Directors from each COBRE Core are Veterinary Molecular Biology faculty and also participate on the Mentoring Board. As a whole, the EC will review COBRE progress reports, set priorities for research efforts on the program projects, provide directives of all the cores' activities, and make recommendations to the PD for future center directions. The External Advisory Committee (EAC) advises on scientific, administrative, and research elements of the COBRE Program. The EAC reviews the MSU COBRE's performance, specific aims, and evaluates the longitudinal progress of the program and individual research projects. EAC activities include concept development, program planning, research project development and mentoring, identification of resources, and evaluation of progress toward stated goals. In some cases, EAC members provide mentoring assistance to Project Leaders and identify potential national mentors and collaborators. The committee is comprised of nationally recognized scientists that includes: John Collier, Harvard University, National Academy of Science Member, and internationally recognized expert on anthrax toxin; Jerry McGhee, University of Alabama-Birmingham and internationally known expert in mucosal immunity; and Christopher Wilson, Head of the Department of Immunology at the University of Washington and internationally recognized expert in immunity to infectious disease. During the 2007-2008 reporting period, Dr. Suzy Swain asked to leave the EAC because of outside obligations in her research program. In her place, the Core was able to recruit Dr. John R. Perfect to serve on the EAC. This change was beneficial because most of the new hires focus on bacterial and fungal pathogenesis, which is not the specialty of Dr. Swain. Dr. Perfect, given his expertise, thus provides an integral oversight to this shift in research focus. Dr. Perfect is the Director of Mycology Research Unit at Duke University. Dr. Perfect's research team investigates anti-fungal agents in animal models of candida and cryptococcal infections. The Administrative Core organizes several programs to enhance research experiences and publicize the MSU COBRE Program, namely the national speaker series, the Annual Research Conference, oversight of the Mini-Grants Program, and support for Bioinformatics Facility and Research within a cross-campus and interdisciplinary collaborative model. The national speaker series brings world-class infectious disease researchers to MSU campus. The COBRE-sponsored speakers tour labs at MSU and meet with COBRE researchers and students. These visits expose all faculty and students to cutting-edge science and provide informal review of ongoing research. COBRE students and faculty prepare for the seminars by reading journal articles and background science on the speakers' research prior to their visits. The annual research conferences and symposia are important venues that allow project leaders and other important researchers to showcase their research, interact with other researchers who share similar interests, and brainstorm new techniques and ways to expand or improve the science. The mini-grants program provides vital funds for pilot projects that have been successful in developing larger, federally-funded grants. Support for bioinformatics is crucial for COBRE, but also for researchers and students across MSU.