AR CAREER DEVELOPMENT COBRE: EXPERIMENTAL CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 实验核心现在有五个核心设施。人类电生理学核心设施承担与人类中潜伏期听觉诱发反应相关的研究，如唤醒(注意前)测量、精神运动警戒任务(PVT)反应时间测试所显示的注意测量、操作测试(OTB)性能所显示的认知功能以及使用近红外光谱(NIRS)测量的相对额叶血流量。图像分析核心是在获奖的第一年开发的，包括一个带有荧光和图像分析软件的共焦显微镜，以及一个用于在体外记录装置中可视化电压依赖和钙染料的高速相机。动物电生理学核心有P13电位和大鼠TMS设施。分子核心有BRT-PCR、Luminex和其他检测方法。TMS核心拥有用于治疗人类TMS的设施，以治疗一些疾病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Experimental Core now has five Core Facilities. The Human Electrophysiology Core Facility undertakes studies related to human midlatency uditory evoked responses as arousal (pre-attentional) measures, attentional measures as exhibited by performance of a Psychomotor Vigilance Task (PVT) reaction time test, cognitive functions as exhibited in the performance of an Operant Test Battery (OTB), and relative frontal lobe blood flow as measured using Near Infrared Spectroscopy (NIRS). The Image Analysis Core was developed during Year 1 of the award and consists of a confocal microscope with fluorescence and image analysis software, along with a high speed camera for visualizing voltage-dependent and calcium dyes in the in vitro recording rig. The Animal Electrophysiology Core has P13 potential and TMS facilities for rats. The Molecular Core has bRT-PCR, Luminex and other assays. The TMS Core has facilities for TMS in humans for a number of disorders.