Center for Translational Neuroscience

描述（由申请人提供）：在最初的奖励期间，我们为研究人员和新兵提供了1300万美元的新拨款，并发表了130篇文章或章节，135篇摘要或演讲。我们设计了一种新的有效的耳鸣治疗方法，开发了一种设备和一种新的药物治疗脊髓损伤后的反射亢进和痉挛，我们开发了一种治疗（消除症状）空间忽视的方法，发现了一种新的睡眠-觉醒控制机制，这也将影响麻醉背后的机制，并开始降低该州低出生体重婴儿的死亡率。然而，我们需要额外的支持，以增加我们的研究人员的临界质量，确保PPG和P50奖，从项目毕业，成为一个独立的转化神经科学中心。我们建议：1)通过对有前途的初级临床医生和基础科学家的资深导师进行指导，加强和扩大转化神经科学研究；2)通过组建研究团队，扩大早期职业研究者的研究项目，包括成功的、以前支持过的研究者和由多位资深研究者指导的新初级研究者。3)通过支持、升级和扩展我们的核心设施，加强对扩展转化神经科学研究至关重要的基础设施；4)通过招聘5名额外的初级科学家，增加UAMS转化神经科学研究人员的临界质量；5)为初级研究人员维持我们成功的职业发展计划，并为成熟的、早期的职业和初级研究人员建立一个新的领导力计划。他们将被要求达到特定的绩效里程碑，以及6)制定一项战略，从COBRE的支持中“毕业”，以确保CTN的连续性。提出的研究计划旨在实现这些目标，并创建一个永久性的转化神经科学中心。鉴于我们在进度报告中概述的成功，尽管可获得的资金发生了巨大变化，但我们有信心实现我们的目标，实现这个项目的“毕业”。我们期待着继续指导更多有前途的临床医生和基础科学家，并帮助改善我们公民的医疗保健。

DESCRIPTION (provided by applicant): During the initial award, we generated >$13 million in new grants to investigators and recruits, and published >130 articles or chapters and >135 abstracts or presentations. We devised a new and effective treatment for tinnitus, developed a device as well as a new drug treatment for hyperreflexia and spasticity after spinal cord injury, we developed a cure (elimination of symptoms) for spatial neglect, discovered a novel mechanism for sleep-wake control that will also impact the mechanisms behind anesthesia, and have begun to decrease the death rate among low birth weight babies in the State. However, we need an additional period of support in order to increase our critical mass of investigators, secure PPG and P50 awards, graduate from the program, and become an independent Center for Translational Neuroscience. We propose to 1) strengthen and augment translational neuroscience research through mentoring promising Junior clinician and basic scientists by established, dedicated senior Mentors, 2) expand the research programs of Early career investigators by forming research teams including successful, previously supported investigators and new Junior investigators mentored by multiple established senior investigators, 3) enhance the infrastructure critical for expanding translational neuroscience research by supporting, upgrading and expanding our Core Facilities, 4) increase the critical mass of translational neuroscience researchers at UAMS by recruiting 5 additional junior scientists, 5) maintain our successful Career Development Program for junior investigators and institute a new Leadership Program for established, early career, and junior researchers, who will be required to meet specific performance milestones, and 6) develop a strategy to "graduate" from COBRE support that will ensure the continuity of the CTN. The Research Plan proposed is designed to meet these aims and create a permanent Center for Translational Neuroscience. Given the successes outlined in our Progress Report, and despite dramatic changes in funding availability, we are confident that we will meet our goals in achieving "graduation" from this program. We look forward to continuing to mentor additional promising clinician and basic scientists, and help improve health care for our citizens. PUBLIC HEALTH RELEVANCE (provided by applicant): Two blocks to translational research have been identified, lack of translation of basic science discoveries into clinical studies, and from clinical studies into medical practice. We designed the CTN to address blocks to these processes, while mentoring promising scientists to careers in translational research. The CTN is a beacon for translational research in the region, and is having an impact on the health of its constituents.