Center for Translational Neuroscience

描述（申请人提供）：我们的总体目标是建立一个永久性的转化神经科学中心（CTN），致力于：a）为维持和扩大第一阶段和第二阶段期间开发的自给自足的研究核心提供支持，这些研究核心对于继续进行基础，临床，转化和基于社区的研究至关重要，以及B）维持合作，通过为试点研究项目提供支持以及指导和培训部分，促进多学科研究环境。为了实现这一目标，我们设计了以下具体目标：目标1：通过支持、升级和精简三个核心设施，加强对CTN至关重要的基础设施。目标二：加强和扩大翻译使命相关的研究，通过指导有前途的早期职业临床医生和基础科学家建立，专门的高级导师。目标3：为了扩大我们成功的职业发展计划为CTN调查员和研究所建立一个新的领导力计划的建立和年轻的研究人员，谁将被要求满足特定的性能里程碑。目标4：支持前沿科学的转化试点研究计划，促进全州范围内的和机构内的额外合作，并创造机会开发和维护有竞争力的研究计划。目标5：系统地收集、分析和使用CTN信息，以回答有关项目、核心和政策的问题，特别是有关其效率和有效性的问题。一个经验丰富的核心咨询委员会将监督所有核心设施的运作和使用情况。外部咨询委员会（EAC）将监督试点研究的科学竞争力，并审查职业发展计划和合作研究的进展。内部咨询委员会将监督早期职业调查员的整合以及与征聘、空间、晋升和任期有关的问题。这些目标将对像我们这样的小机构产生更大的影响，并促进巩固一个成功和富有成效的CTN，为国家计划树立榜样。我们可能的成功是通过产生超过3000万美元的新的赠款支持和出版超过450篇文章和章节的Phses I和II认证。

DESCRIPTION (provided by applicant): Our overall goal is the establishment of a permanent Center for Translational Neuroscience (CTN) dedicated to, a) providing support for maintaining and expanding self-sufficient research cores developed during Phases I and II that are essential for the continuing conduct of basic, clinical, translational, and community based research, and b) sustaining a collaborative, multidisciplinary research environment by providing support for pilot study projects, as well as mentoring and training components. To attain this goal, we designed the following specific aims: Aim 1: To enhance the infrastructure critical to the CTN by supporting, upgrading, and streamlining three Core Facilities. Aim 2: To strengthen and augment translational mission relevant research through mentoring promising early career clinicians and basic scientists by established, dedicated senior Mentors. Aim 3: To expand our successful Career Development Program for CTN investigators and institute a new Leadership Program for established and young researchers, who will be required to meet specific Performance Milestones. Aim 4: To support a translational pilot study research program of cutting edge science, promote state wide and additional collaborations within the institution, and create opportunities to develop and maintain competitive research programs. Aim 5: To systematically collect, analyze, and use CTN information to answer questions about projects, cores, and policies, especially about their efficiency and effectiveness. An experienced Core Advisory Committee (CAC) will oversee operation and utilization of all the Core Facilities. The External Advisory Committee (EAC) will oversee scientific competitiveness of pilot studies and review progress of the Career Development Program and collaborative research. The Internal Advisory Committee (lAC) will oversee integration of early career investigators and issues related to recruitment, space, and promotion and tenure. These aims will have a greater impact at a small institution such as ours and facilitate the solidification of a successful and productiv CTN that will set an example for national programs. Our likely success is certified by generating over $30 million in new grant support and publishing over 450 articles and chapters in Phses I and II.