Center for Translational Neuroscience

转化神经科学中心

• 批准号: 7907250
• 负责人: Edgar E. Garcia-Rill
• 金额: $ 60.91万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-09 至 2012-09-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7907250
• 关键词: Center; Translational; Neuroscience

DESCRIPTION (provided by applicant): During the initial award, we generated >$13 million in new grants to investigators and recruits, and published >130 articles or chapters and >135 abstracts or presentations. We devised a new and effective treatment for tinnitus, developed a device as well as a new drug treatment for hyperreflexia and spasticity after spinal cord injury, we developed a cure (elimination of symptoms) for spatial neglect, discovered a novel mechanism for sleep-wake control that will also impact the mechanisms behind anesthesia, and have begun to decrease the death rate among low birth weight babies in the State. However, we need an additional period of support in order to increase our critical mass of investigators, secure PPG and P50 awards, graduate from the program, and become an independent Center for Translational Neuroscience. We propose to 1) strengthen and augment translational neuroscience research through mentoring promising Junior clinician and basic scientists by established, dedicated senior Mentors, 2) expand the research programs of Early career investigators by forming research teams including successful, previously supported investigators and new Junior investigators mentored by multiple established senior investigators, 3) enhance the infrastructure critical for expanding translational neuroscience research by supporting, upgrading and expanding our Core Facilities, 4) increase the critical mass of translational neuroscience researchers at UAMS by recruiting 5 additional junior scientists, 5) maintain our successful Career Development Program for junior investigators and institute a new Leadership Program for established, early career, and junior researchers, who will be required to meet specific performance milestones, and 6) develop a strategy to "graduate" from COBRE support that will ensure the continuity of the CTN. The Research Plan proposed is designed to meet these aims and create a permanent Center for Translational Neuroscience. Given the successes outlined in our Progress Report, and despite dramatic changes in funding availability, we are confident that we will meet our goals in achieving "graduation" from this program. We look forward to continuing to mentor additional promising clinician and basic scientists, and help improve health care for our citizens. PUBLIC HEALTH RELEVANCE (provided by applicant): Two blocks to translational research have been identified, lack of translation of basic science discoveries into clinical studies, and from clinical studies into medical practice. We designed the CTN to address blocks to these processes, while mentoring promising scientists to careers in translational research. The CTN is a beacon for translational research in the region, and is having an impact on the health of its constituents.

描述(由申请人提供)：在最初的奖项中，我们为调查人员和新人提供了1300万美元的新赠款，并发表了130篇文章或章节和135篇摘要或演示文稿。我们设计了一种新的有效的耳鸣治疗方法，开发了一种治疗脊髓损伤后反射亢进和痉挛的设备以及一种新的药物治疗方法，我们开发了一种治疗空间忽视的方法(消除症状)，发现了一种新的睡眠-唤醒控制机制，该机制也将影响麻醉背后的机制，并已开始降低该州低出生体重婴儿的死亡率。然而，我们需要额外的一段时间的支持，以增加我们的研究人员的临界数量，获得PPG和P50奖项，从该项目毕业，并成为一个独立的翻译神经科学中心。我们建议1)通过指导有前途的初级临床医生和基础科学家，由有经验的、敬业的高级导师来加强和扩大翻译神经科学研究，2)通过组建研究团队来扩大早期职业研究人员的研究计划，包括成功的、以前得到支持的研究人员和由多名知名高级调查人员指导的新的初级调查人员，3)通过支持、升级和扩展我们的核心设施来增强对扩大翻译神经科学研究至关重要的基础设施，4)通过额外招聘5名初级科学家来增加UAMS的翻译神经科学研究人员的临界质量，5)维持我们针对初级调查人员的成功职业发展计划，并为已经建立的、早期职业生涯和初级研究人员建立一个新的领导力计划，世卫组织将被要求达到具体的业绩里程碑，以及6)制定一项战略，从科布雷支助“毕业”，以确保CTN的连续性。提出的研究计划旨在满足这些目标，并创建一个永久的翻译神经科学中心。鉴于我们在进度报告中概述的成功，尽管资金来源发生了戏剧性的变化，但我们有信心实现我们的目标，实现从这一计划“毕业”的目标。我们期待着继续指导更多有前途的临床医生和基础科学家，并帮助改善我们公民的医疗保健。 公共卫生相关性(由申请者提供)：已经确定了转化研究的两个障碍，即缺乏将基础科学发现转化为临床研究，以及从临床研究转化为医疗实践。我们设计CTN来解决这些过程中的障碍，同时指导有前途的科学家从事翻译研究。CTN是该地区翻译研究的灯塔，正在对其成员的健康产生影响。