Technology and Comp Core

技术与核心竞争力

• 批准号: 8094319
• 负责人: GARY D PAIGE
• 金额: $ 17.1万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8094319
• 关键词: Anatomy; Animal Experimentation; Animals; Behavior; Behavioral; Clinical; Collaborations; Communication; Communities; Consultations; Custom; Devices; Diagnostic; Disease; Educational process of instructing; Electronics; Engineering; Ensure; Environment; Equipment; Faculty; Fostering; Future; Goals; Growth; Histology; Human; Image; Image Analysis; Individual; Laboratories; Labyrinth; Maintenance; Mass Spectrum Analysis; Mechanics; Mediating; Modification; Molecular; Molecular Analysis; Molecular Biology; Molecular Genetics; Mus; Neurobiology; Otolaryngology; Outcome; Patients; Perception; Physiological; Population; Preparation; Process; Productivity; Protein Analysis; Proteins; Proteomics; Psychophysics; Publications; Research; Research Personnel; Rodent; Rodent Model; Sampling; Screening procedure; Services; Solutions; Structure; System; Techniques; Technology; Time; Tissues; base; design; digital; human subject; image processing; image reconstruction; improved; innovation; instrumentation; interest; member; mutant; neurophysiology; new technology; novel; programs; ranpirnase; reconstruction; relating to nervous system; repaired; technological innovation; tissue preparation; tool

The laboratories of the Core-Center are uniformly technologically sophisticated and automated. Further, the faculty are engaged in a broad range of approaches, from molecular biology to cellular neurophysiology to behavior and perception, and utilize a variety of animal subjects as well as humans and patients. These attributes form a common need for technical services across the Core-Center. The Research Services Core (RSC) provides four sets of key services. Each operates in complementary partnerships with other NIHsupported Centers and Programs, and with the Department of Neurobiology and Anatomy. This structure ensures the highest quality of services and facilities possible, while maximizing efficiency and economy. The Histology & Imaging Unit provides tissue preparation, image analysis and reconstruction technologies, An additional component is an Imaging Facility that includes digital and wet darkrooms that facilitate transforming research findings into figures and images for publication and teaching tools. All investigators in the Co re-Center that use animals have a need for histological services, and yet the need does not justify full-time commitments. A collective solution is ideal. The Electronic and Mechanical Shop provides essential services to all labs, given the common requirement for equipment repair and maintenance overtime, and modifications and construction of electronic and mechanical components and devices on a semi-regular basis. The Shop exploits modern automated design-build technologies routinely. New faculty have expanded cellular-molecular-genetic levels of inquiry within the CNCS, and these approaches entail the use of mouse and other rodent models, including mutant and genetically engineered populations. A new Animal Research Unit assists CNCS investigators using rodents with purchasing, husbandry, recordkeeping, and basic physiologic and diagnostic screening in support of their research goals. The new Proteomics Unit offers modern protein analysis technology and services, from design and consultation to purification strategies for proteins of interest and clinical sample analysis. The Unit also assists Pis in the preparation of materials mass spectrometry. The Units of the RSC provide sophisticated services across the Co re-Center that are well suited for a common and centralized structure and function. This Core offers a high quality and accessible set of services to CNCS faculty that enhances the productivity of our research and stimulates interactions across laboratories. The attractive environment produced in turn catalyzes technological and scientific collaboration, and attracts new investigators to our labs and research goals.

核心中心的实验室均技术先进且自动化。更远， 教师们从事从分子生物学到细胞神经生理学的广泛研究 行为和感知，并利用各种动物受试者以及人类和患者。这些 属性形成了整个核心中心对技术服务的共同需求。研究服务核心 (RSC) 提供四套关键服务。每个项目都与 NIH 支持的其他项目建立互补的合作伙伴关系 中心和项目，以及神经生物学和解剖学系。这个结构 确保尽可能提供最高质量的服务和设施，同时最大限度地提高效率和经济性。 组织学和成像单元提供组织制备、图像分析和重建 技术，另一个组成部分是成像设施，包括数字和湿暗室， 促进将研究成果转化为用于出版和教学工具的图形和图像。全部 核心研究中心使用动物的研究人员需要组织学服务，但需要 并不能证明全职承诺是合理的。集体解决方案是理想的。机电车间 鉴于设备维修和维护的共同要求，为所有实验室提供基本服务 加班，以及电子和机械部件和设备的修改和建造 半定期的基础上。该商店经常利用现代自动化设计构建技术。新教师 扩大了 CNCS 内的细胞分子遗传学研究水平，这些方法需要 使用小鼠和其他啮齿动物模型，包括突变体和基因工程种群。一个新的 动物研究单位协助 CNCS 研究人员使用啮齿动物进行采购、饲养、记录保存、 以及基本的生理和诊断筛查以支持他们的研究目标。新的 蛋白质组学部门提供现代蛋白质分析技术和服务，从设计和咨询到 感兴趣的蛋白质和临床样品分析的纯化策略。该股还协助 Pis 材料制备质谱。 RSC 各单位在整个核心中心提供完善的服务，非常适合 共同且集中的结构和功能。该核心提供了一套高质量且易于使用的服务 CNCS 教员提高了我们的研究生产力并刺激了跨领域的互动 实验室。所产生的有吸引力的环境反过来又促进了技术和科学合作， 并吸引新的研究人员来到我们的实验室和研究目标。