Technology and Comp Core

技术与核心竞争力

• 批准号: 7877966
• 负责人: GARY D PAIGE
• 金额: $ 16.57万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7877966
• 关键词: Anatomy; Animal Experimentation; Animals; Behavior; Behavioral; Clinical; Collaborations; Communication; Communities; Consultations; Custom; Devices; Diagnostic; Disease; Educational process of instructing; Electronics; Engineering; Ensure; Environment; Equipment; Faculty; Fostering; Future; Goals; Growth; Histology; Human; Image; Image Analysis; Individual; Laboratories; Labyrinth; Maintenance; Mass Spectrum Analysis; Mechanics; Mediating; Modification; Molecular; Molecular Analysis; Molecular Biology; Molecular Genetics; Mus; Neurobiology; Otolaryngology; Outcome; Patients; Perception; Physiological; Population; Preparation; Process; Productivity; Protein Analysis; Proteins; Proteomics; Psychophysics; Publications; Research; Research Personnel; Rodent; Rodent Model; Sampling; Science; Screening procedure; Services; Solutions; Structure; System; Techniques; Technology; Time; Tissues; base; design; digital; human subject; image processing; image reconstruction; improved; innovation; instrumentation; interest; member; mutant; neurophysiology; new technology; novel; programs; ranpirnase; reconstruction; relating to nervous system; repaired; technological innovation; tissue preparation; tool

The laboratories of the Core-Center are uniformly technologically sophisticated and automated. Further, the faculty are engaged in a broad range of approaches, from molecular biology to cellular neurophysiology to behavior and perception, and utilize a variety of animal subjects as well as humans and patients. These attributes form a common need for technical services across the Core-Center. The Research Services Core (RSC) provides four sets of key services. Each operates in complementary partnerships with other NIHsupported Centers and Programs, and with the Department of Neurobiology and Anatomy. This structure ensures the highest quality of services and facilities possible, while maximizing efficiency and economy. The Histology & Imaging Unit provides tissue preparation, image analysis and reconstruction technologies, An additional component is an Imaging Facility that includes digital and wet darkrooms that facilitate transforming research findings into figures and images for publication and teaching tools. All investigators in the Co re-Center that use animals have a need for histological services, and yet the need does not justify full-time commitments. A collective solution is ideal. The Electronic and Mechanical Shop provides essential services to all labs, given the common requirement for equipment repair and maintenance overtime, and modifications and construction of electronic and mechanical components and devices on a semi-regular basis. The Shop exploits modern automated design-build technologies routinely. New faculty have expanded cellular-molecular-genetic levels of inquiry within the CNCS, and these approaches entail the use of mouse and other rodent models, including mutant and genetically engineered populations. A new Animal Research Unit assists CNCS investigators using rodents with purchasing, husbandry, recordkeeping, and basic physiologic and diagnostic screening in support of their research goals. The new Proteomics Unit offers modern protein analysis technology and services, from design and consultation to purification strategies for proteins of interest and clinical sample analysis. The Unit also assists Pis in the preparation of materials mass spectrometry. The Units of the RSC provide sophisticated services across the Co re-Center that are well suited for a common and centralized structure and function. This Core offers a high quality and accessible set of services to CNCS faculty that enhances the productivity of our research and stimulates interactions across laboratories. The attractive environment produced in turn catalyzes technological and scientific collaboration, and attracts new investigators to our labs and research goals.

核心中心的实验室在技术上是统一的，并且是自动化的。更远， 从分子生物学到细胞神经生理学 行为和感知，并利用各种动物受试者以及人类和患者。这些 属性构成了整个核心中心技术服务的普遍需求。研究服务核心 （RSC）提供四组关键服务。每个人都与其他NIHSpport建立互补的合作伙伴关系 中心和计划，以及神经生物学和解剖学系。这个结构 确保最高质量的服务和设施，同时最大程度地提高效率和经济。 组织学和成像单元提供组织准备，图像分析和重建 Technologies，另一个组件是一个成像设施，包括数字和湿的暗室 促进将研究发现转换为出版和教学工具的图形和图像。全部 CO重新中心使用动物的调查人员需要组织学服务，但需要 没有证明全职承诺是合理的。集体解决方案是理想的。电子和机械商店 考虑到设备维修和维护的共同要求，为所有实验室提供基本服务 加班，对电子和机械组件和设备的修改和构建 半定期基础。该商店通常会定期利用现代自动化设计构建技术。新教师 已经扩大了CNC中的细胞分子遗传学水平，这些方法需要 使用小鼠和其他啮齿动物模型，包括突变体和基因工程种群。一个新 动物研究单位协助CNCS调查人员使用啮齿动物进行购买，饲养，记录保存， 以及基本的生理和诊断筛查，以支持其研究目标。新的 蛋白质组学单元提供现代蛋白质分析技术和服务，从设计和咨询到 感兴趣的蛋白质和临床样本分析的纯化策略。该部门还可以帮助PIS 制备材料质谱法。 RSC的单位提供了整个CO重新中心的复杂服务，非常适合A 通用和集中的结构和功能。该核心提供高质量且可访问的服务集 向CNC的教师提高我们的研究生产力并刺激跨越跨越的互动 实验室。产生的有吸引力的环境反过来催化技术和科学合作， 并吸引了新的研究人员进入我们的实验室和研究目标。