CENTER FOR NAVIGATION AND COMMUNICATION SCIENCE

描述(由申请人提供)：日常生活中最引人注目的特征包括在我们的环境中导航和相互交流的能力。这些功能是生存的基础，但也是最先遇到疾病或老化的神经系统问题的功能之一。罗切斯特大学拥有一套由NIH支持的研究项目，致力于导航和通信背后的感觉、运动、综合和细胞机制。研究范围从分子和遗传方法到清醒动物的细胞神经生理学，再到人类感知，并包括强大的翻译和临床元素。这些特点为我们的P-30导航和通信科学中心(CNCS)提供了一个令人信服的框架。在过去的拨款期间，CNCS现在以超出所有预期的稳定状态运行，这在很大程度上要归功于与之相匹配的敬业和敬业的教职员工的坚定领导，合作和共享的核心服务，强大的咨询和质量保证流程，以及事实证明对新的合作和新的研究人员具有吸引力的基础设施和社区。 CNCS使研究人员能够高效地共享昂贵、耗时、必要但繁琐的创新研究服务。CNCS包括三个核心：1)人类受试者核心，以整合和协调各项目受试者的招募、筛选、调度和数据库；2)研究服务核心，包括组织学和成像股(组织准备、图像分析和重建)、电子/机械车间(修复和建造实验室部件和设备)、动物研究股(突变和基因敲除准备、饲养和筛选)和蛋白质组学股(专门蛋白质分析)；3)技术和计算核心，包括实验室技术单元(用于刺激和行为控制、数据和分析的自动化实验室系统)和计算单元，以支持PC和网络操作、软件库、网络支持和员工培训。一些服务单位与神经生物学和解剖学系、视觉科学中心(NEI-P30)和两个项目(NIA-P01和NINDS-P01)共享支持。CNCS利用了我们固有的大学生态，并通过在专用空间中的杰出核心人员和设施来增强我们的实验室能力。所有的核心和单元都高效地运行，并平衡了提供所需的有时平凡的服务以及转变为未来能力的新颖和创新解决方案的综合目标。这确保了在强大的基础设施中为所有人提供高质量、高效和多样化的服务，从而丰富了我们研究的生产力，促进了研究人员之间的合作，吸引了新的教职员工和学生加入我们的研究任务，促进了进一步的机构支持，并最终为社区和国家的健康做出了贡献。

DESCRIPTION (provided by applicant): The most compelling features of daily life include the ability to navigate through our environment and to communicate with each other. These functions are fundamental to survival, but are also among the first to encounter trouble in the diseased or aging nervous system. The University of Rochester holds a set of NIH-supported research programs dedicated to the sensory, motor, integrative, and cellular mechanisms underlying navigation and communication. Research ranges from molecular and genetic approaches to cellular neurophysiology in awake animals to human perception, and includes strong translational and clinical elements. These characteristics provide a compelling framework for our P-30, Center for Navigation and Communication Sciences (CNCS). New this past grant period, the CNCS is now operating at a steady-state that exceeds all expectations, largely due to committed leadership matched by a dedicated and engaged faculty and staff, cooperative and shared Core services, a strong advisory and quality assurance process, and an infrastructure and community that has proven attractive to new collaborations and new investigators. The CNCS allows investigators to efficiently share costly, time-consuming, essential but cumbersome, and innovative research services. The CNCS includes three Cores: 1) a Human Subjects Core to consolidate and coordinate the recruitment, screening, scheduling, and databasing of subjects across projects; 2) a Research Services Core that includes a Histology & Imaging Unit (tissue preparation, image analysis & reconstruction), an Electronic/Mechanical Shop (repair and construction of lab components and devices), an Animal Research Unit (mutant and knockout preparations, husbandry and screening), and a Proteomics Unit (specialized protein analysis); and 3) a Technology and Computation Core, including a Lab Technology Unit (automated lab systems for stimulus and behavioral control, data and analysis) and a Computation Unit to support PC and network operations, software library, web support, and staff training. Some service Units share support with the Department of Neurobiology & Anatomy, the Center for Visual Science (an NEI-P30), and two program projects (an NIA-P01 and an NINDS-P01). The CNCS exploits our inherently collegiate ecology and augments our lab capabilities through outstanding Core personnel and facilities in dedicated space. All Cores and Units operate efficiently and balance the combined goals of providing both needed though sometimes-mundane services as well as novel and innovative solutions that transform into tomorrow's capabilities. This ensures high-quality, efficient, and diverse services to all, in a robust infrastructure that enriches the productivity of our research, promotes collaborations among investigators, attracts new faculty and students to our research mission, facilitates further institutional support, and ultimately contributes to the health of the community and the nation.