Glycemic Load and Resistance Training on Endothelial Function and Inflammation

血糖负荷和阻力训练对内皮功能和炎症的影响

基本信息

批准号：
8116267
负责人：
CHRISTIAN K Roberts
金额：
$ 75.75万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8116267
关键词：
Acute Address Adherence Aerobic Alternative Therapies American Area Biological Markers Blood Glucose Blood Vessels Body Composition Carbohydrates Cardiovascular Diseases Caring Chronic Comorbidity Coronary heart disease Data Development Diabetes prevention Diet Diet Modification Dietary Component Effectiveness Epidemic Epidemiologic Studies Epidemiology Exercise Fatty acid glycerol esters Flow Cytometry Functional disorder Future Glucose Glycemic Index Health Healthcare Hepatic Inflammation Inflammatory Inflammatory Response Insulin Insulin Resistance Intervention Intervention Studies Intervention Trial Knowledge Left Life Style Magnetic Resonance Imaging Mediating Metabolic Metabolic syndrome Monitor Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Overweight Oxidative Stress Pathology Patients Phenotype Plasma Population Prevention strategy Preventive Primary Prevention Protein Analysis Public Health RNA Randomized Randomized Controlled Trials Research Design Resistance Risk Risk Factors Sampling Specificity System Techniques Testing Time Training Training Programs Translating Variant Visceral Woman Work brachial artery cardiovascular disorder risk cardiovascular risk factor combat cytokine design diabetes prevention program diabetes risk diabetic dietary control efficacy testing efficacy trial follow-up glucose monitor glucose tolerance high standard improved inflammatory marker insight insulin sensitivity intravenous glucose tolerance test men monocyte novel novel therapeutics nutrition response strength training young adult

项目摘要

DESCRIPTION (provided by applicant): This project is prompted by the urgent public health need to find optimal nutrition and exercise prevention strategies to reduce future cardiovascular disease and type 2 diabetes risk in young adults. This project aims to investigate the efficacy of a low-glycemic load diet both alone, and in combination with resistance training, to ameliorate endothelial dysfunction, monocyte inflammation and 24-hr glycemic variations. 160 obese young adults will be randomly assigned to 1 of 4 groups for 12 weeks: 1) a control high-glycemic load diet; 2) a low- glycemic load diet; 3) a high-glycemic load diet + resistance training; or 4) low-glycemic load diet + resistance training. The aims are to determine if: 1) a low-GL diet improves endothelial function, monocyte inflammation and 24-hr glycemic variations compared to a standard high-glycemic load, Westernized diet and 2) a low-GL diet + RT has an additive effect with low-GL diet to improve endothelial function, monocyte inflammation and 24-hr glycemic variations. Dependent variables include endothelial function by brachial artery flow-mediated dilation (FMD), monocyte phenotyping by flow cytometry and PCR/protein analysis, 24-hr continuous glucose monitoring systems, insulin sensitivity by frequently sampled intravenous glucose tolerance test, whole body composition by DEXA, visceral and hepatic fat fraction by MRI, and acute responses to a high-glycemic index meal. The hypotheses are that a low-glycemic load diet will improve the above key cardiovascular risk related dependent variables and that the addition of resistance training will induce additive effects. This project will, for the first time, compare the isolated and combined effects of a low-glycemic load diet and/or resistance training on endothelial function, monocyte inflammation and 24-hr glycemic variations. If the hypotheses are upheld, new therapeutic options will become available to improve primary prevention of vascular dysfunction, chronic inflammation and insulin resistance, including in those young adults where alternative therapies may be less effective. PUBLIC HEALTH RELEVANCE: For the first time, a randomized controlled trial using a low glycemic-load diet and/or resistance training will be carried out in obese young men and women. This efficacy trial should have major public health implications to the tens of millions of Americans currently obese, presenting with less than optimal vascular function, chronic inflammatory status and insulin sensitivity, thus providing insight into novel preventive health strategies. Furthermore, due to individualized specificity of compliance issues for each patient, the arsenal of therapies for prescription needs to be large; the current proposal will potentially increase the range of therapies.

描述（由申请人提供）：该项目是由于公共卫生需要寻找最佳的营养和预防策略，以减少未来的心血管疾病和2型糖尿病风险。该项目旨在仅单独研究低血糖负荷饮食的功效，并结合耐药性训练，以改善内皮功能障碍，单核细胞炎症和24小时血糖变化。 160名肥胖年轻人将随机分配到4组中的1个，持续12周：1）对照高血糖负荷饮食； 2）低血糖负荷饮食； 3）高血糖负荷饮食 +耐药性训练；或4）低血糖负荷饮食 +耐药性训练。目的是确定：1）与标准的高血糖载荷，西式饮食和2）低GL饮食 + RT相比，低于GL饮食是否可以改善内皮功能，单核细胞炎症和24小时血糖变化。 Dependent variables include endothelial function by brachial artery flow-mediated dilation (FMD), monocyte phenotyping by flow cytometry and PCR/protein analysis, 24-hr continuous glucose monitoring systems, insulin sensitivity by frequently sampled intravenous glucose tolerance test, whole body composition by DEXA, visceral and hepatic fat fraction by MRI, and acute responses to a高血糖指数餐。假设是低血糖负荷饮食将改善上述关键心血管风险相关的因变量，并且添加耐药性训练将引起添加剂效应。该项目将首次比较低血糖负荷饮食和/或耐药训练对内皮功能，单核细胞炎症和24小时血糖变异的孤立和组合作用。如果维持假设，则将可以使用新的治疗选择，以改善对血管功能障碍，慢性炎症和胰岛素抵抗的主要预防，包括在那些替代疗法效果较低的年轻人中。公共卫生相关性：首次使用低血糖饮食和/或抵抗训练的随机对照试验将在肥胖的年轻人中进行。这项疗效试验应该对目前肥胖的数以百万计的美国人具有重大的公共卫生影响，其表现不足以最佳的血管功能，慢性炎症状态和胰岛素敏感性，从而提供了对新型预防健康策略的见识。此外，由于对每个患者的合规性问题的个性化特异性，处方疗法的武器库必须大；当前的建议将有可能增加疗法的范围。