Effect of Diet on Oxidative Stress, NO and Hypertension
饮食对氧化应激、一氧化氮和高血压的影响
基本信息
- 批准号:6406389
- 负责人:
- 金额:$ 4.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-09-30 至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The specific aim of this proposal is to
investigate potential mechanisms by which a diet high in saturated fat and
refined carbohydrates (sucrose) induces insulin resistance and hypertension
compared to a diet high in unrefined carbohydrate and low in fat. Hypertension
afflicts one quarter of the adult population in the United States and is a
hallmark risk factor for myocardial infarction, stroke and congestive heart
failure. Although its cause is largely unknown, it is associated with insulin
resistance/ hyperinsulinemia, oxidative stress and endothelial dysfunction. The
primary hypothesis to be tested in this grant is that a high-fat, refined
carbohydrate diet (HFS) increases the production of reactive oxygen/nitrogen
species (e.g. ONOO-), contributing to insulin resistance, as well as
sequestrating and inactivating NO leading to hypertension. To test this
hypothesis, male and female rats will be raised on either the HFS or a low-fat,
complex carbohydrate diet (LFCC) and blood pressure will be measured via the
tail-cuff and telemetry methods. Isolated arterial segments will be used to
test endothelial function. Plasma/urinary measurements will assess NO
metabotites, MDA and cGMP levels. Biochemical studies will be. conducted on
several tissues, including aorta, heart and kidney to measure eNOS, iNOS, nNOS
and SOD proteins, NOS and SOD activities, nitrotyrosine formation and tissue
cGMP levels. Studies will also be conducted to investigate the value of dietary
modification (switching to an LFCC diet or antioxidant supplementation) and
exercise training for controlling hypertension, as well as the role of caloric
restriction on the development of hypertension. The results of these studies
may provide a mechanism to explain how HFS type diets cause insulin resistance
and hypertension, and how a LFCC diet, antioxidant therapy or exercise training
aid in the control of insulin resistance and hypertension.
描述(由申请人提供):该提案的具体目的是
研究高饱和脂肪饮食和
精制碳水化合物(蔗糖)诱发胰岛素抵抗和高血压
与富含未精制碳水化合物和低脂肪的饮食相比。高血压
困扰着美国四分之一的成年人口,是一种
心肌梗塞、中风和充血性心脏病的标志性危险因素
失败。尽管其原因尚不清楚,但与胰岛素有关
抵抗/高胰岛素血症、氧化应激和内皮功能障碍。这
本次拨款要测试的主要假设是,高脂肪、精制的
碳水化合物饮食(HFS)增加活性氧/氮的产生
物种(例如 ONOO-),导致胰岛素抵抗,以及
隔离和灭活 NO,导致高血压。为了测试这个
假设,雄性和雌性大鼠将在 HFS 或低脂饮食中饲养,
复杂碳水化合物饮食 (LFCC) 和血压将通过
尾套和遥测方法。孤立的动脉段将用于
测试内皮功能。血浆/尿液测量将评估 NO
代谢物、MDA 和 cGMP 水平。生化研究将是。进行于
多种组织,包括主动脉、心脏和肾脏,可测量 eNOS、iNOS、nNOS
和 SOD 蛋白、NOS 和 SOD 活性、硝基酪氨酸形成和组织
cGMP 水平。还将进行研究以调查饮食的价值
改变(改用 LFCC 饮食或补充抗氧化剂)和
控制高血压的运动训练以及热量的作用
限制高血压的发展。这些研究的结果
可能提供一种机制来解释 HFS 型饮食如何导致胰岛素抵抗
和高血压,以及 LFCC 饮食、抗氧化疗法或运动训练如何
有助于控制胰岛素抵抗和高血压。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHRISTIAN K Roberts其他文献
CHRISTIAN K Roberts的其他文献
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{{ truncateString('CHRISTIAN K Roberts', 18)}}的其他基金
Glycemic Load and Resistance Training on Endothelial Function and Inflammation
血糖负荷和阻力训练对内皮功能和炎症的影响
- 批准号:
8241937 - 财政年份:2011
- 资助金额:
$ 4.02万 - 项目类别:
Glycemic Load and Resistance Training on Endothelial Function and Inflammation
血糖负荷和阻力训练对内皮功能和炎症的影响
- 批准号:
8447588 - 财政年份:2011
- 资助金额:
$ 4.02万 - 项目类别:
Glycemic Load and Resistance Training on Endothelial Function and Inflammation
血糖负荷和阻力训练对内皮功能和炎症的影响
- 批准号:
8583141 - 财政年份:2011
- 资助金额:
$ 4.02万 - 项目类别:
Glycemic Load and Resistance Training on Endothelial Function and Inflammation
血糖负荷和阻力训练对内皮功能和炎症的影响
- 批准号:
8116267 - 财政年份:2011
- 资助金额:
$ 4.02万 - 项目类别:
Vascular function, cardiovascular disease biomarkers and the Latino paradox
血管功能、心血管疾病生物标志物和拉丁裔悖论
- 批准号:
7881066 - 财政年份:2010
- 资助金额:
$ 4.02万 - 项目类别:
Effect of Diet on Oxidative Stress, NO and Hypertension
饮食对氧化应激、一氧化氮和高血压的影响
- 批准号:
6647161 - 财政年份:2002
- 资助金额:
$ 4.02万 - 项目类别:
Effect of Diet on Oxidative Stress, NO and Hypertension
饮食对氧化应激、一氧化氮和高血压的影响
- 批准号:
6527819 - 财政年份:2002
- 资助金额:
$ 4.02万 - 项目类别:
Vascular function, cardiovascular disease biomarkers and the Latino paradox
血管功能、心血管疾病生物标志物和拉丁裔悖论
- 批准号:
8296590 - 财政年份:
- 资助金额:
$ 4.02万 - 项目类别:
Vascular function, cardiovascular disease biomarkers and the Latino paradox
血管功能、心血管疾病生物标志物和拉丁裔悖论
- 批准号:
8604732 - 财政年份:
- 资助金额:
$ 4.02万 - 项目类别:
Vascular function, cardiovascular disease biomarkers and the Latino paradox
血管功能、心血管疾病生物标志物和拉丁裔悖论
- 批准号:
8378328 - 财政年份:
- 资助金额:
$ 4.02万 - 项目类别:
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