Vascular function, cardiovascular disease biomarkers and the Latino paradox

血管功能、心血管疾病生物标志物和拉丁裔悖论

基本信息

项目摘要

The Latino health paradox intrigues researchers because it seems too good to be true: Better health outcomes for individuals with fewer resources. Why does acculturation to norms in the US, despite being accompanied by increased access to health resources and income, seem to contribute to worse health outcomes? To date, the study of acculturation and health risk has focused on behavioral factors, rather than on physiological phenotypes. There is an urgent public health need to gain insight into the cardiovascular health of Latinos, especially Mexican-Americans, an ethnic group increasingly prone to obesity-related comorbidities but understudied for cardiovascular risk factors. This interdisciplinary project will determine cardiovascular function in younger and older related adults varying in generational and immigrant status to increase understanding of the basis for the Latino acculturation paradox. 200 subjects from 100 families in East Los Angeles, including one family member from both an older and a younger generation will be enrolled. The project aims are to 1) Evaluate cardiovascular phenotypes, including arterial stiffness, endothelial function, cardiovascular risk factors and metabolic syndrome in Latino families; and 2) Evaluate the extent to which the Latino paradox holds within these families, based on their generational status and level of acculturation. Measurements will be determined at baseline and after 24 months follow-up. The primary outcome is arterial stiffness measured by applanation tonometry. Secondary outcomes include endothelial function via brachial artery flow-mediated dilation, cardiorespiratory fitness via incremental exercise test, and cardiovascular disease risk biomarkers including markers of endothelial dysfunction (soluble intracellular adhesion molecule-1 and E-selectin), oxidative stress (oxidized LDL and myeloperoxidase), systemic inflammation (C-reactive protein), and fibrinolysis. Other outcomes required to test the hypotheses include components of metabolic syndrome, diet, physical activity level and measures of acculturation. If our hypotheses are supported, more importance may be placed on taking acculturation into account when designing lifestyle change interventions designed to improve Latino cardiovascular health.
拉丁美洲人的健康悖论引起了研究人员的兴趣,因为它似乎好得令人难以置信:更健康

项目成果

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CHRISTIAN K Roberts其他文献

CHRISTIAN K Roberts的其他文献

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{{ truncateString('CHRISTIAN K Roberts', 18)}}的其他基金

Glycemic Load and Resistance Training on Endothelial Function and Inflammation
血糖负荷和阻力训练对内皮功能和炎症的影响
  • 批准号:
    8241937
  • 财政年份:
    2011
  • 资助金额:
    $ 32.58万
  • 项目类别:
Glycemic Load and Resistance Training on Endothelial Function and Inflammation
血糖负荷和阻力训练对内皮功能和炎症的影响
  • 批准号:
    8447588
  • 财政年份:
    2011
  • 资助金额:
    $ 32.58万
  • 项目类别:
Glycemic Load and Resistance Training on Endothelial Function and Inflammation
血糖负荷和阻力训练对内皮功能和炎症的影响
  • 批准号:
    8583141
  • 财政年份:
    2011
  • 资助金额:
    $ 32.58万
  • 项目类别:
Glycemic Load and Resistance Training on Endothelial Function and Inflammation
血糖负荷和阻力训练对内皮功能和炎症的影响
  • 批准号:
    8116267
  • 财政年份:
    2011
  • 资助金额:
    $ 32.58万
  • 项目类别:
Effect of Diet on Oxidative Stress, NO and Hypertension
饮食对氧化应激、一氧化氮和高血压的影响
  • 批准号:
    6647161
  • 财政年份:
    2002
  • 资助金额:
    $ 32.58万
  • 项目类别:
Effect of Diet on Oxidative Stress, NO and Hypertension
饮食对氧化应激、一氧化氮和高血压的影响
  • 批准号:
    6527819
  • 财政年份:
    2002
  • 资助金额:
    $ 32.58万
  • 项目类别:
Effect of Diet on Oxidative Stress, NO and Hypertension
饮食对氧化应激、一氧化氮和高血压的影响
  • 批准号:
    6406389
  • 财政年份:
    2001
  • 资助金额:
    $ 32.58万
  • 项目类别:
Vascular function, cardiovascular disease biomarkers and the Latino paradox
血管功能、心血管疾病生物标志物和拉丁裔悖论
  • 批准号:
    8296590
  • 财政年份:
  • 资助金额:
    $ 32.58万
  • 项目类别:
Vascular function, cardiovascular disease biomarkers and the Latino paradox
血管功能、心血管疾病生物标志物和拉丁裔悖论
  • 批准号:
    8604732
  • 财政年份:
  • 资助金额:
    $ 32.58万
  • 项目类别:
Vascular function, cardiovascular disease biomarkers and the Latino paradox
血管功能、心血管疾病生物标志物和拉丁裔悖论
  • 批准号:
    8378328
  • 财政年份:
  • 资助金额:
    $ 32.58万
  • 项目类别:

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Doctoral Dissertation Research: Acculturation and Mental Health among Immigrant Communities
博士论文研究:移民社区的文化适应和心理健康
  • 批准号:
    2314850
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    2023
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Acculturation, Social Context, Loneliness, and the Development of Alcohol Problems in Latinx Individuals
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    10651527
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    10755947
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拉丁裔阿尔茨海默病的危险因素:心血管疾病风险、文化适应、小血管疾病和阿尔茨海默病生物标志物之间的关系
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了解巴基斯坦、孟加拉国和亚洲印度移民的健康差异:社会文化背景、文化适应和复原力资源的作用
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