University of Michigan O'Brien Kidney Translational Resource Center (MKTC)

密歇根大学奥布莱恩肾脏转化资源中心 (MKTC)

• 批准号: 10746899
• 负责人: Subramaniam Pennathur
• 金额: $ 96.51万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746899
• 关键词: Acute; Acute Renal Failure with Renal Papillary Necrosis; Area; Basic Science; Big Data; Bioinformatics; Biological; Biological Markers; Biological Models; Cessation of life; Chronic Kidney Failure; Clinical; Clinical Research; Collaborations; Communities; Community Outreach; Complex; Data; Data Analyses; Data Analytics; Data Coordinating Center; Data Set; Databases; Development; Diagnosis; Disease; Education; End stage renal failure; Ensure; Faculty; Fostering; Functional disorder; Future; Genetic; Goals; Health; Hematology; Human; Human Resources; Individual; Infrastructure; Injury; Injury to Kidney; Intervention; Kidney; Kidney Diseases; Medicine; Methodology; Michigan; Mission; Modernization; Molecular; Multiomic Data; Online Systems; Pathway interactions; Patient Care; Patients; Physiology; Prognostic Marker; Proteomics; Public Health; Renal function; Research; Research Personnel; Research Training; Resource Development; Resources; Risk; Scientific Advances and Accomplishments; Services; Structure; Students; Surrogate Endpoint; System; Systems Biology; Technology; Therapeutic; Translational Research; Translations; Universities; Urology; Validation; Work; base; bench to bedside; biological systems; career; cohort; data mining; design; disability; diversity and equity; effective intervention; effective therapy; equity, diversity, and inclusion; experience; high school; improved; individual patient; innovation; interdisciplinary collaboration; lipidomics; metabolomics; mortality; mortality risk; multidimensional data; novel; novel diagnostics; novel therapeutics; operation; outreach; outreach program; patient oriented; premature; prognostic; programs; recruit; research study; tool; transcriptomics; treatment strategy; undergraduate student; user-friendly

ABSTRACT – CENTER OVERVIEW The main goal of the University of Michigan O'Brien Kidney Translational Resource Center (MKTC) is to provide an effective translational research pipeline to develop novel, mechanistic treatment strategies for patients with kidney diseases. The center will support all basic and patient-oriented kidney research investigators using a 3-pronged approach: Enable investigators to investigate the molecular causes and endpoints of acute and chronic kidney diseases; Dissemination and support of the most modern and powerful systems biological approaches for all investigators to help them effectively identify novel and robust biomarkers, endpoints and targets for diagnosis and treatment of AKI and CKD; Expert analysis and integration of cohort and systems data for our research base investigators through the use of sophisticated bioinformatics and database integration that promote identification of specific pathways and targets for treatments for individuals or groups of subjects with AKI and CKD. The Center's aims are to: 1) Introduce, stimulate and apply state-of-the-art systems biological approaches to kidney disease research investigators through the use of sophisticated but user-friendly genetic, transcriptomic, proteomic, metabolomic and lipidomic approaches through the Applied Systems Biology Core; 2) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that accompany systems biological approaches to their functional implications regarding kidney disease development, diagnosis, progression and therapeutic potential through the Data Analytic Services Core (DASC); 3) Serve as national resource and expand worldwide outreach efforts via Nephroseq, Nephrocell and tranSMART; 4) Use the Student Programs and robust enrichment programs to entice trainees and faculty into kidney research, improve diversity, equity and inclusion and support researchers in their ongoing kidney research. 5) Share best practices and resources with the other National Resource Centers under the U54 consortium and work with Data Coordinating Center to enable widespread dissemination.

摘要-中心概述 密歇根大学奥布莱恩肾脏转化资源中心（MKTC）的主要目标 是提供一个有效的转化研究管道，以开发新的， 肾病患者的治疗策略。该中心将支持所有基本的和以病人为导向的肾脏 研究人员使用三管齐下的方法：使研究人员能够研究分子 急性和慢性肾脏疾病的病因和终点;传播和支持 现代和强大的系统生物学方法，为所有研究人员，以帮助他们有效地识别 用于诊断和治疗阿基和CKD的新型稳健生物标志物、终点和靶点;专家 分析和整合队列和系统数据，为我们的研究基地研究人员通过使用 先进的生物信息学和数据库集成，促进识别特定的途径 以及用于治疗患有阿基和CKD的个体或受试者组的靶标。 该中心的目标是： 1)介绍，刺激和应用最先进的系统生物学方法治疗肾脏疾病 研究人员通过使用复杂但用户友好的遗传学，转录组学， 通过应用系统生物学核心的蛋白质组学、代谢组学和脂质组学方法; 2)增强对复杂肾脏疾病和多标量数据集的理解， 伴随系统生物学方法，以了解其对肾脏的功能影响 通过数据分析确定疾病发展、诊断、进展和治疗潜力 服务核心（DASC）; 3)作为国家资源，通过Nephroseq、Nephrocell扩大全球推广工作 和transSMART; 4)使用学生计划和强大的充实计划，以吸引学员和教师进入 肾脏研究，提高多样性，公平性和包容性，并支持研究人员在其持续的 肾脏研究 5)与U 54下的其他国家资源中心分享最佳做法和资源 联合会并与数据协调中心合作，以实现广泛传播。