University of Michigan O'Brien Kidney Translational Resource Center (MKTC)

摘要-中心概述 密歇根大学奥布莱恩肾脏翻译资源中心(MKTC)的主要目标 是提供一条有效的转化性研究管道，以开发新的、机械的治疗方法 肾脏疾病患者的治疗策略。该中心将支持所有基本的和以患者为中心的肾脏 研究人员使用三管齐下的方法：使调查人员能够调查分子 急慢性肾脏疾病的原因和终点；MOST的传播和支持 为所有研究人员提供现代和强大的系统生物学方法，帮助他们有效地识别 AKI和CKD诊断和治疗的新的和强大的生物标志物、终点和靶点；专家 为我们的研究基地调查人员分析和整合队列和系统数据 先进的生物信息学和数据库集成，促进特定途径的识别 以及AKI和CKD患者个人或群体的治疗目标。 该中心的目标是： 1)引进、激励和应用最先进的系统生物学方法来治疗肾脏疾病 研究人员通过使用复杂但用户友好的基因、转录本 通过应用系统生物学核心的蛋白质组、代谢组和脂组学方法； 2)加强对复杂肾脏疾病和多标量数据集的了解 伴随系统对肾脏功能影响的生物学研究 通过数据分析了解疾病的发展、诊断、进展和治疗潜力 服务核心(DASC)； 3)作为国家资源，并通过Nephroseq、Nephrocell扩大全球外联努力 和TransSMART； 4)使用学生计划和稳健充实计划来吸引学员和教职员工 肾脏研究，提高多样性、公平性和包容性，并支持研究人员进行 肾脏研究。 5)与U54下的其他国家资源中心分享最佳做法和资源 并与数据协调中心合作，以实现广泛传播。

ABSTRACT – CENTER OVERVIEW The main goal of the University of Michigan O'Brien Kidney Translational Resource Center (MKTC) is to provide an effective translational research pipeline to develop novel, mechanistic treatment strategies for patients with kidney diseases. The center will support all basic and patient-oriented kidney research investigators using a 3-pronged approach: Enable investigators to investigate the molecular causes and endpoints of acute and chronic kidney diseases; Dissemination and support of the most modern and powerful systems biological approaches for all investigators to help them effectively identify novel and robust biomarkers, endpoints and targets for diagnosis and treatment of AKI and CKD; Expert analysis and integration of cohort and systems data for our research base investigators through the use of sophisticated bioinformatics and database integration that promote identification of specific pathways and targets for treatments for individuals or groups of subjects with AKI and CKD. The Center's aims are to: 1) Introduce, stimulate and apply state-of-the-art systems biological approaches to kidney disease research investigators through the use of sophisticated but user-friendly genetic, transcriptomic, proteomic, metabolomic and lipidomic approaches through the Applied Systems Biology Core; 2) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that accompany systems biological approaches to their functional implications regarding kidney disease development, diagnosis, progression and therapeutic potential through the Data Analytic Services Core (DASC); 3) Serve as national resource and expand worldwide outreach efforts via Nephroseq, Nephrocell and tranSMART; 4) Use the Student Programs and robust enrichment programs to entice trainees and faculty into kidney research, improve diversity, equity and inclusion and support researchers in their ongoing kidney research. 5) Share best practices and resources with the other National Resource Centers under the U54 consortium and work with Data Coordinating Center to enable widespread dissemination.