CLINICAL PHARMACOLOGY AND ANALYTICAL CHEMISTRY CORE

临床药理学和分析化学核心（核心E）旨在提供 一个集中的单位，以促进艾滋病毒/艾滋病相关的临床， 在UNC-CH和我们的合作机构进行转化和基础科学研究，并建立 与其他国家和国际机构的艾滋病调查人员合作。我们汇集了一个 一组在分析化学、药理学和生物化学领域建立起来的研究人员、合作者和顾问， 相关领域这些研究人员监督一个现代化的、设备齐全的综合分析实验室。 核心E为艾滋病毒/艾滋病调查人员提供的服务包括标本的获取和处理 HIV感染和未感染材料的药理学咨询和药代动力学支持， 药效学研究;样品分析;和药理学结果的解释。所有 分析是在CLIA认证的最先进的分析实验室进行的， 高效液相色谱，气相色谱，毛细管电泳，核磁共振 共振光谱和质谱。实验室位于市中心， 为联合国日内瓦办事处艾滋病毒/艾滋病调查人员提供访问机会。 在核心E建立之前，艾滋病毒/艾滋病调查人员努力通过他们的分析和 药物需求的依赖于不可靠的时间表，没有资金的同事或承包 将研究转移到昂贵的私人机构。在大多数情况下，重要的药理学研究被忽略了 缺乏资金或可靠的专业知识。核心E现在满足了分析和药理学需求， 艾滋病毒/艾滋病研究人员的主要赠款没有不必要的财政负担。此外， 这一设施促进了新的和重要的艾滋病毒/艾滋病相关药物研究，资金和跨学科 合作。

The purpose of the Clinical Pharmacology and Analytical Chemistry Core (Core E) is to provide a centralized unit to facilitate the pharmacological and analytical studies of HIV/AIDS related clinical, translational, and basic science research at UNC-CH and at our collaborating institutions, and to establish collaboration with AIDS investigators at other national and international institutions. We bring together a group of established investigators, collaborators, and advisors in analytical chemistry, pharmacology, and related fields. These investigators oversee a modern and well-equipped, composite analytical laboratory. The services provided to the HIV/AIDS investigators by Core E include specimen procurement and handling of HIV infected and noninfected material; pharmacologic consultation and support for pharmacokinetic and pharmacodynamic investigations; analysis of samples; and interpretation of pharmacologic results. All analyses are conducted in a CLIA-certified, state of the art analytical laboratory that includes high performance liquid chromatography, gas chromatography, capillary electrophoresis, nuclear magnetic resonance spectroscopy, and mass spectrometry. The laboratory is centrally located and has convenient access for the HIV/AIDS investigators at UNC-CH. Prior to the establishment of Core E, HIV/AIDS investigators struggled through their analytical and pharmacologic needs by relying on the undependable timetables of unfunded colleagues or by contracting out the studies to costly private facilities. In most cases important pharmacological studies were bypassed for a lack of funding or reliable expertise. Core E now fills the analytical and pharmacological needs of HIV/AIDS researchers without undue financial burden on their primary grants. In addition, the availability of this facility has stimulated new and important HIV/AIDS related drug research, funding, and interdisciplinary collaborations.