CLINICAL PHARMACOLOGY AND ANALYTICAL CHEMISTRY CORE

临床药理学和分析化学核心

• 批准号: 8080831
• 负责人: Angela D Kashuba
• 金额: $ 36.4万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8080831
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Analytical Chemistry; Anti-Retroviral Agents; Applications Grants; Arts; Basic Science; Biological; Biological Assay; Bypass; Capillary Electrophoresis; Cerebrospinal Fluid; Clinical; Clinical Pharmacology; Collaborations; Computers and Advanced Instrumentation; Consultations; Contracts; Data; Development; Drug Kinetics; Funding; Gas Chromatography; Generations; Genital system; Grant; HIV; Hand; High Pressure Liquid Chromatography; Human Milk; Human Resources; Individual; Institution; International; Investigation; Knowledge; Laboratories; Leadership; Manuscripts; Mass Spectrum Analysis; Measures; Methods; Mission; NMR Spectroscopy; Opportunistic Infections; Pharmaceutical Preparations; Pharmacodynamics; Pharmacology; Plasma; Publishing; Research; Research Methodology; Research Personnel; Sampling; Science; Scientist; Services; Site; Specimen; Training; analytical method; cost; drug development; improved; instrumentation; interdisciplinary collaboration; interest; member; method development; novel; novel strategies; success; time use

The purpose of the Clinical Pharmacology and Analytical Chemistry Core (Core E) is to provide a centralized unit to facilitate the pharmacological and analytical studies of HIV/AIDS related clinical, translational, and basic science research at UNC-CH and at our collaborating institutions, and to establish collaboration with AIDS investigators at other national and international institutions. We bring together a group of established investigators, collaborators, and advisors in analytical chemistry, pharmacology, and related fields. These investigators oversee a modern and well-equipped, composite analytical laboratory. The services provided to the HIV/AIDS investigators by Core E include specimen procurement and handling of HIV infected and noninfected material; pharmacologic consultation and support for pharmacokinetic and pharmacodynamic investigations; analysis of samples; and interpretation of pharmacologic results. All analyses are conducted in a CLIA-certified, state of the art analytical laboratory that includes high performance liquid chromatography, gas chromatography, capillary electrophoresis, nuclear magnetic resonance spectroscopy, and mass spectrometry. The laboratory is centrally located and has convenient access for the HIV/AIDS investigators at UNC-CH. Prior to the establishment of Core E, HIV/AIDS investigators struggled through their analytical and pharmacologic needs by relying on the undependable timetables of unfunded colleagues or by contracting out the studies to costly private facilities. In most cases important pharmacological studies were bypassed for a lack of funding or reliable expertise. Core E now fills the analytical and pharmacological needs of HIV/AIDS researchers without undue financial burden on their primary grants. In addition, the availability of this facility has stimulated new and important HIV/AIDS related drug research, funding, and interdisciplinary collaborations.

临床药理学和分析化学核心(核心E)的目的是提供一个 促进艾滋病毒/艾滋病相关临床的药理学和分析研究的中央单位， 在北卡罗来纳大学和我们的合作机构进行翻译和基础科学研究，并建立 与其他国家和国际机构的艾滋病调查人员合作。我们带来了一个 由分析化学、药理学和其他领域的知名研究者、合作者和顾问组成 相关字段。这些调查人员监督着一个现代化的、设备齐全的综合分析实验室。 核心E向艾滋病毒/艾滋病调查员提供的服务包括样本采购和处理。 艾滋病毒感染和非感染材料；药理学咨询和药代动力学支持 药效学研究；样品分析；以及药理学结果的解释。全 分析在CLIA认证的最先进的分析实验室中进行，该实验室包括 高效液相色谱、气相色谱、毛细管电泳法、核磁法 共振光谱学和质谱学。实验室位于中心位置，拥有便利的 北卡罗来纳大学-CHS艾滋病毒/艾滋病调查员的准入。 在建立核心E之前，艾滋病毒/艾滋病调查人员努力完成他们的分析和 依靠没有资金的同事不可靠的时间表或通过签约来满足药物需求 把研究交给昂贵的私人机构。在大多数情况下，重要的药理学研究都被忽略了 因为缺乏资金或可靠的专业知识。Core E现在满足了分析和药物方面的需求 艾滋病毒/艾滋病研究人员在其主要补助金上没有不必要的财政负担。此外，还提供了 这一设施促进了与艾滋病毒/艾滋病有关的新的和重要的药物研究、资助和跨学科 合作。