ACTIVITY DEPENDENT REFINEMENT OF INHIBITORY NETWORKS IN BARREL CORTEX

桶状皮层抑制网络的活动依赖性细化

• 批准号: 8167716
• 负责人: Qian-Quan Sun
• 金额: $ 11.24万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167716
• 关键词: Brain; Cerebral cortex; Computer Retrieval of Information on Scientific Projects Database; Cortical Dysplasia; Development; Dyslexia; Epilepsy; Equilibrium; Funding; Glutamates; Grant; Inhibitory Synapse; Institution; Interneurons; Microscopic; Modification; Process; Property; Research; Research Personnel; Resources; Role; Schizophrenia; Sensory; Source; Synapses; System; Translating; United States National Institutes of Health; barrel cortex; experience; insight; neocortical; nervous system disorder; neuron development; postnatal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this proposal is to understand the mechanisms by which developing inhibitory brain circuits are able to adapt to sensory inputs, and to maintain their balance with the developing excitatory circuits. During early brain development, neurons in the cerebral cortex establish connections that are then fine tuned by experience-dependent mechanisms. Although much is now known regarding processes of glutamatergic maturation and activity-dependent modification of glutamatergic synapses for network formation, postnatal development of neocortical GABAergic synapses and their role in activity-dependent modification remains unclear. The proposed research will utilize a combination of electrophysiologic recording and microscopic analyses to examine how developmental changes of inhibitory synapses and interneuron network properties are translated into a mature, functional cortical system. This research will provide new information about mechanisms of cortical development and experience-dependant plasticity. It will help us gain further insights into mechanisms underlying several developmental related neurological disorders such as cortical dysplasia, schizophrenia, epilepsy and dyslexia, in which early endogenous and exogenous unfavorable conditions create long-lasting impacts on the mature cortex.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的目的是了解发育中的抑制性脑回路能够适应感觉输入的机制，并与发育中的兴奋性回路保持平衡。在大脑发育的早期，大脑皮层中的神经元建立了连接，然后通过经验依赖机制进行微调。虽然现在已经知道了很多关于多巴胺能神经元的成熟过程和多巴胺能神经元突触网络形成的活动依赖性修饰，但新皮层GABA能神经元突触的出生后发育及其在活动依赖性修饰中的作用仍然不清楚。拟议的研究将利用电生理记录和显微镜分析相结合，以研究抑制性突触和中间神经元网络特性的发育变化如何转化为成熟的功能性皮质系统。本研究将为皮层发育和经验依赖性可塑性的机制提供新的信息。 这将有助于我们进一步了解一些发育相关的神经系统疾病，如皮质发育不良，精神分裂症，癫痫和阅读障碍，其中早期内源性和外源性不利条件对成熟皮质产生长期影响的机制。