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Reformulating Hearing Assessment: Translating recent discoveries through a large-

重新制定听力评估：通过大型研究转化最近的发现

基本信息

批准号：
8070368
负责人：
Sumitrajit Dhar
金额：
$ 65.53万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-01 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8070368
关键词：
Acoustics Age Alterations in Hearing Area Audiology Auditory Auditory Physiology Auditory system Awareness Behavioral Benchmarking Calibration Clinic Clinical Cochlea Collection Communication Computer software Data Development Devices Diagnostic Diagnostic tests Early Diagnosis Effectiveness Elements Engineering Environment Evaluation Exercise External auditory canal Frequencies General Population Glean Goals Health Hearing Individual Laboratories Life Maps Measurement Measures Medical Methods Monitor Nature Noise Output Pathology Patient Self-Report Patients Peripheral Phase Physiological Prevention Preventive Medicine Principal Investigator Procedures Process Protocols documentation Publishing Questionnaires Research Personnel Resources Sampling Screening procedure Sensitivity and Specificity Signal Transduction Site Societies Source Speech Perception Speed Stimulus System Techniques Technology Test Result Testing Time Translating Universities Validation Work behavior test clinical application cohort cost cost effective cost effectiveness evidence base experience hearing impairment improved infancy innovation insight new technology novel novel diagnostics otoacoustic emission programs prototype software development sound tool usability user friendly software user-friendly validation studies

项目摘要

DESCRIPTION (provided by applicant): As a society and nation we are increasingly aware of the value of preventive medicine. In the area of hearing health, prevention is achieved by awareness of elements hazardous to hearing and the early diagnosis of small changes in hearing status. The current diagnostic protocol used in audiology has been in place for over half a century and is insensitive to small changes in auditory physiology. We propose to evaluate novel methods of detecting alterations in hearing status. These novel methods are implemented within a test-battery that should effectively evaluate several aspects of hearing function and relate to communication difficulties experienced by individuals in the real world. Work during the first phase of the project evaluates the effectiveness of a new diagnostic system currently under development in our labs and examines the efficacy of methods of calibration, as well as recording of stimulus frequency otoacoustic emissions. This system will integrate the administration of all tests proposed here and be able to administer them over an unprecedented range of frequencies. The results of this phase are incorporated into a second phase where a battery of tests is evaluated in an age-distributed group of 400 subjects. In the final and largest phase of the study, we glean the most effective tests from the previous phase and evaluate their efficacy in a battery, as well as individually, on a sample of 1200 subjects. This phase is conducted over the last three years of the project period, at three sites. Two of the proposed study sites are functional audiology clinics in university and medical environments, respectively. Consistent with the translational goals of the project we develop a new measurement device which incorporates new methods of evaluating the auditory system. We evaluate these tests in a large cohort of diverse subjects. Finally, we engage in aggressive, evidence-based promotion of these new technologies and methods, as suggested by the overall findings of our study.

描述（由申请人提供）：作为一个社会和国家，我们越来越意识到预防医学的价值。在听力健康领域，预防是通过了解对听力有害的因素和早期诊断听力状况的微小变化来实现的。目前用于听力学的诊断协议已经存在了半个多世纪，并且对听觉生理学的微小变化不敏感。我们建议评估新的方法来检测听力状态的变化。这些新的方法是在一个测试电池内实现的，该测试电池应该有效地评估听力功能的几个方面，并与真实的世界中的个人所经历的沟通困难有关。该项目第一阶段的工作评估了我们实验室目前正在开发的新诊断系统的有效性，并检查了校准方法的有效性，以及刺激频率耳声发射的记录。这一系统将整合本文提出的所有测试的管理，并能够在前所未有的频率范围内管理这些测试。这一阶段的结果被纳入第二阶段，在第二阶段，在400名受试者的年龄分布组中评估一组测试。在研究的最后也是最大的阶段，我们从前一阶段收集了最有效的测试，并在1200名受试者的样本中评估了它们的有效性。这一阶段在项目期的最后三年在三个地点进行。两个拟议的研究地点分别是大学和医疗环境中的功能性听力学诊所。与该项目的翻译目标相一致，我们开发了一种新的测量设备，其中包括评估听觉系统的新方法。我们评估这些测试在一个大的队列不同的主题。最后，正如我们研究的总体结果所建议的那样，我们积极地、以证据为基础地推广这些新技术和方法。