An in vitro system to study antiviral strategies against Hepatitis C virus
An in vitro system to study antiviral strategies against Hepatitis C virus
批准号:
8073585
负责人:
DAVID L WYLES
金额:
$11.64万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-06-15 至 2013-05-31
关键词:
AmericanAntiviral AgentsBiological AssayCell Culture SystemChronic Hepatitis CChronic viral hepatitisClinicClinical ResearchClinical TrialsCollectionCountryDevelopmentDrug resistanceEscape MutantEscherichia coliFirefly LuciferasesGenomicsGenotypeGrowthHIV-1Hepatitis C virusHumanIn VitroInterferonsInvestigationLentivirus VectorLibrariesLuciferasesModificationMolecularMolecular TargetMorbidity - disease rateMutationPathway interactionsPersonsProcessProteinsRNA replicationRepliconReporterResearch PersonnelResistanceRibavirinSite-Directed MutagenesisSmall Interfering RNAStructural GenesStructural ProteinSystemTestingTherapeuticToxic effectTransfectionTranslational ResearchViral ProteinsVirusVirus InhibitorsVirus Replicationanti-hepatitis Cbasechemotherapyclinical practicedrug developmentdrug discoveryfitnessin vitro Assayin vivoinhibitor/antagonistmutantnovelpressureprogramsresearch studyresistance mechanismresistance mutationtoolvirology
中文摘要
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (provided by applicant): The Description section was not included in the original submission of the amended application.
期刊论文(9)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1093/infdis/jir802
发表时间:
2012-02
期刊:
The Journal of infectious diseases
影响因子:
--
作者:
[Haihong Zhu;F. Wong-Staal;Haekyung Lee;A. Syder;J. McKelvy;R. Schooley;D. Wyles]
通讯作者:
Haihong Zhu;F. Wong-Staal;Haekyung Lee;A. Syder;J. McKelvy;R. Schooley;D. Wyles
Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors.
丙型肝炎病毒 (HCV) NS4A 拮抗剂与 HCV 蛋白酶和聚合酶抑制剂联合使用的协同作用。
DOI:
10.1128/aac.01208-07
发表时间:
2008
期刊:
Antimicrobial agents and chemotherapy
影响因子:
4.9
作者:
[Wyles,DavidL, Kaihara,KellyA, Schooley,RobertT]
通讯作者:
Schooley,RobertT
DOI:
10.1038/nchembio.217
发表时间:
2009-11
期刊:
NATURE CHEMICAL BIOLOGY
影响因子:
14.8
作者:
[Parsons, Jerod, Castaldi, M. Paola, Dutta, Sanjay, Dibrov, Sergey M., Wyles, David L., Hermann, Thomas]
通讯作者:
Hermann, Thomas
Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication.
9-(S)-[3-烷氧基-2-(膦酰甲氧基)丙基]核苷烷氧基烷基酯的合成和抗病毒评价:丙型肝炎病毒和HIV-1复制的抑制剂。
DOI:
10.1016/j.bmc.2011.06.009
发表时间:
2011
期刊:
Bioorganic & medicinal chemistry
影响因子:
3.5
作者:
[Valiaeva,Nadejda, Wyles,DavidL, Schooley,RobertT, Hwu,JuliaB, Beadle,JamesR, Prichard,MarkN, Hostetler,KarlY]
通讯作者:
Hostetler,KarlY
Rong's numbers: accelerating progress in HCV therapeutic research.
荣的数字:加速丙肝治疗研究的进展。
DOI:
10.1126/scitranslmed.3001183
发表时间:
2010
期刊:
Science translational medicine
影响因子:
17.1
作者:
[Wyles,DavidL, Schooley,RobertT]
通讯作者:
Schooley,RobertT
Analysis of HIV/HCV Sexual Transmission Pairs Using Ultra-Deep Sequencing
-
批准号:8424954
-
项目类别:
-
资助金额:$19.38万
-
财政年份:2012
-
负责人:DAVID L WYLES
-
依托单位:
The Hepatitis Care Connection Program (Hep-Care Connect)
-
批准号:8511093
-
项目类别:
-
资助金额:$83.5万
-
财政年份:2012
-
负责人:DAVID L WYLES
-
依托单位:
The Hepatitis Care Connection Program (Hep-Care Connect)
-
批准号:8703253
-
项目类别:
-
资助金额:$92.6万
-
财政年份:2012
-
负责人:DAVID L WYLES
-
依托单位:
Analysis of HIV/HCV Sexual Transmission Pairs Using Ultra-Deep Sequencing
-
批准号:8330105
-
项目类别:
-
资助金额:$23.22万
-
财政年份:2012
-
负责人:DAVID L WYLES
-
依托单位:
An in vitro system to study antiviral strategies against Hepatitis C virus
-
批准号:7231131
-
项目类别:
-
资助金额:$10.56万
-
财政年份:2007
-
负责人:DAVID L WYLES
-
依托单位:
An in vitro system to study antiviral strategies against Hepatitis C virus
-
批准号:7434505
-
项目类别:
-
资助金额:$10.56万
-
财政年份:2007
-
负责人:DAVID L WYLES
-
依托单位:
An in vitro system to study antiviral strategies against Hepatitis C virus
-
批准号:7845718
-
项目类别:
-
资助金额:$11.64万
-
财政年份:2007
-
负责人:DAVID L WYLES
-
依托单位:
An in vitro system to study antiviral strategies against Hepatitis C virus
-
批准号:7623862
-
项目类别:
-
资助金额:$11.64万
-
财政年份:2007
-
负责人:DAVID L WYLES
-
依托单位:
海外基金