Compound Management System with High-Throughput Tube and Vial Picking Workstation

具有高通量试管和小瓶拾取工作站的化合物管理系统

• 批准号: 7840360
• 负责人: LIDIA C SAMBUCETTI
• 金额: $ 82.65万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7840360
• 关键词: Agonist; Basic Science; Biology; Carbon; Chemicals; Clinical; Collection; Communicable Diseases; Controlled Environment; Employee; Funding; Inflammation; Libraries; Ligands; Malignant Neoplasms; Mechanics; Methods; Neurosciences; Nicotinic Receptors; Occupations; Output; Productivity; Refrigeration; Research; Research Personnel; Resources; Retrieval; Sampling; Screening procedure; Source; System; Temperature; Therapeutic; Time; Training; Translations; Tube; United States National Institutes of Health; Vial device; hypocretin; inhibitor/antagonist; interest; malignant neurologic neoplasms; mu opioid receptors; novel therapeutics

DESCRIPTION (provided by applicant): The SRI Screening Center (SSC) requests funds to purchase a Compound Management System (ASM- Store/Server System), with high-throughput sample input and output for tubes and vials, from Hamilton Inc, Hopkinton, MA USA. The SSC provides centralized high-throughput storage capabilities and makes SRI's proprietary compounds accessible to SRI investigators involved in research on cancer, neurological conditions, inflammation, and infectious diseases. The long-term objective of purchasing the ASM-Store is to accelerate the translation of NIH-funded basic research into discovery of novel therapeutic compounds. SRI's library includes over 100,000 compounds, and the ASM-Store, which inputs and retrieves samples robotically, will increase research productivity by reducing the effort required to access compounds. Efficient utilization of SRI compounds will immediately benefit the research of 5-10 NIH-funded projects involving discovery of chemical probes and therapeutic molecules; and will ultimately permit all basic and applied researchers at SRI to productively utilize the compound library. Efficient access to medicinal-quality compounds is crucial to promote the translation of concepts and targets from basic research into novel therapeutics. SRI's compound collection is a rich source of biologically active molecules with excellent optimization potential, many of which have yielded clinical candidates. An automated system is needed to fully utilize the library and permit rapid collection of screening sets or cherry picking of compounds from computational searches. All aspects of compound storage and retrieval will be reliable and efficient, benefiting all investigators seeking to identify chemicals with activity against a target of interest. NIH- funded projects in cancer and neurosciences that will immediately use this resource include AMPK modulators, MTF inhibitors, hypocretin agonists, selective nicotinic receptor ligands, mixed NOP/mu receptor ligands and TGF-B activators. Our participation as a "Comprehensive Screening Center" for NCI's Chemical Biology Consortium, starting June 2009, will also be enhanced by this compound storage system. Specific aims: ' Achieve reliable and rapid compound storage and retrieval through purchase of a Hamilton ASM-store. ' Organize and store SRI's compound library in a controlled environment and train potential users. ' Facilitate and catalyze the use of SRI's compound library by NIH funded investigators. The purchase of an ASM-Store will support the economy by creating jobs at Hamilton Inc, Hopkinton, MA, and its 75-100 local parts suppliers. Use and training of potential users will require one full-time SRI employee, and additional jobs may be created by the new projects that are created from increased use of the compound library. The ASM-Store keeps compounds at a controlled temperature of -200C, using an efficient mechanical refrigeration method that has a significantly lower carbon footprint than comparable refrigeration systems.

描述（由申请人提供）： SRI筛选中心（SSC）申请资金从汉密尔顿公司（Hopkinton，MA USA）购买化合物管理系统（ASM-存储/服务器系统），该系统具有试管和小瓶的高通量样本输入和输出。SSC提供集中的高通量存储能力，使SRI的专有化合物可供参与癌症、神经系统疾病、炎症和传染病研究的SRI研究人员使用。收购ASM商店的长期目标是加速NIH资助的基础研究转化为新型治疗化合物的发现。SRI的库包括超过100，000种化合物，而自动输入和检索样品的ASM-Store将通过减少访问化合物所需的工作量来提高研究生产力。SRI化合物的有效利用将立即有利于5-10个NIH资助的涉及发现化学探针和治疗分子的项目的研究;并最终允许SRI的所有基础和应用研究人员有效地利用化合物库。有效获得具有药用质量的化合物对于促进概念和目标从基础研究转化为新疗法至关重要。SRI的化合物集合是具有优异优化潜力的生物活性分子的丰富来源，其中许多已经产生了临床候选物。需要一个自动化系统来充分利用库，并允许快速收集筛选集或从计算搜索中挑选化合物。化合物存储和检索的所有方面都将是可靠和有效的，有利于所有寻求识别具有针对感兴趣目标的活性的化学品的研究人员。NIH资助的癌症和神经科学项目将立即使用该资源，包括AMPK调节剂，MTF抑制剂，下丘脑分泌素激动剂，选择性烟碱受体配体，混合NOP/mu受体配体和TGF-B激活剂。从2009年6月开始，我们作为NCI化学生物学联盟的“综合筛选中心”的参与也将通过这种化合物储存系统得到加强。具体目标：“通过购买汉密尔顿ASM存储，实现可靠和快速的化合物存储和检索。 在受控环境中组织和储存SRI的化合物库，并培训潜在用户。 “促进和促进NIH资助的研究人员使用SRI的化合物库。购买ASM商店将通过在马萨诸塞州霍普金顿的汉密尔顿公司及其75-100家当地零件供应商创造就业机会来支持经济。潜在用户的使用和培训将需要一名全职的SRI员工，并且由于化合物库的使用增加而产生的新项目可能会创造更多的就业机会。ASM-Store采用高效的机械制冷方法，将化合物保持在-200 ℃的受控温度下，与同类制冷系统相比，其碳足迹显著降低。