Enhanced Fluoropolymer Membrane Reactors for Production of Pharmaceutical Interme

描述（由申请人提供）：许多药物活性成分和中间体的商业合成需要酸催化剂和除去水以驱动反应完成。典型的反应包括羧酸与醇的酯化、Friedel-Crafts酰化和烷基化、席夫碱、缩醛和缩酮的形成以及芳香族化合物的硝化。虽然常见的无机酸通常用作催化剂，但它们会产生产品纯化，废物处理，安全，环境和国土安全等问题。Compact Membrane Systems，Inc. (CMS)提出开发膜反应器（MR）以增强这些方法并消除由现有酸催化剂产生的问题。CMS建议开发增强型膜反应器，并展示相关药物反应物的性能。CMS已经获得了关键的行业专家，以促进这一计划。在这个项目中，CMS将制造膜反应器。所得的MR将用于运行药学上感兴趣的反应，如芳族化合物的烷基化和硝化。预期CMS膜反应器相对于现有工艺将产生更高的产率、更快的反应和更少的污染产物，并且由于聚合物的全氟化性质将具有非常长的寿命。由于产品的生产成本较低，选择在较低温度下合成以最大化API功效，最大限度地减少废物以及消除强无机酸的运输和储存，社会将受益。 公共卫生相关性：在医药产品的合成中，使用催化膜反应器可以替代酸催化剂，降低成本，提高处理量。

DESCRIPTION (provided by applicant): The commercial syntheses of many pharmaceutical active ingredients and intermediates require acid catalysts and the removal of water to drive reactions to completion. Typical reactions include esterifications of carboxylic acids with alcohols, Friedel-Crafts acylations and alkylations, Schiff base, acetal and ketal formation and nitrations of aromatic compounds. Although common mineral acids are typically employed as catalysts, they create issues with product purification, waste disposal, safety, the environment and homeland security. Compact Membrane Systems, Inc. (CMS) proposes to develop membrane reactors (MR) to enhance these processes and eliminate the problems created by existing acid catalysts. CMS proposes developing enhanced membrane reactors and demonstrating performance on relevant pharmaceutical reactants. CMS has obtained key industry experts to facilitate this program. In this program, CMS will fabricate the membrane reactors. The resultant MR will be used to run reactions of pharmaceutical interest such as the alkylation and nitration of aromatic compounds. Expectation is that the CMS membrane reactor will result in higher yields, faster reactions and less contaminated products relative to incumbent processes and will have a very long lifetime due to the perfluorinated nature of the polymer. Society will benefit due to the lower production costs for the products, option for synthesis at lower temperature to maximize API efficacy, minimization of waste products and elimination of the transport and storage of strong mineral acids. PUBLIC HEALTH RELEVANCE: Project Narrative The use of catalytic membrane reactors can replace acid catalysts in the synthesis of pharmaceutical products at lower cost and higher processing throughput.