Enhanced Fluoropolymer Membrane Reactors for Production of Pharmaceutical Interme

描述(申请人提供)：许多药物活性成分和中间体的商业合成需要酸催化剂和水的去除来推动反应完成。典型的反应包括羧酸与醇的酯化反应、Friedel-Craft酰化和烷基化反应、席夫碱、缩醛和缩酮的生成以及芳香化合物的硝化反应。尽管常见的无机酸通常被用作催化剂，但它们在产品净化、废物处理、安全、环境和国土安全方面造成了问题。紧凑型膜系统公司(CMS)建议开发膜反应器(MR)来增强这些过程，并消除现有酸催化剂造成的问题。CMS建议开发增强型膜反应器，并展示相关药物反应物的性能。CMS已经获得了关键的行业专家来促进这一计划。在这个项目中，CMS将制造膜反应器。生成的MR将用于进行具有制药意义的反应，如芳香族化合物的烷基化和硝化。预计与现有工艺相比，CMS膜反应器将产生更高的产率、更快的反应速度和更少的污染产品，并且由于聚合物的全氟化性质，将具有非常长的寿命。社会将受益，因为产品的生产成本较低，可选择在较低温度下合成以最大限度地提高原料药的功效，最大限度地减少废物产品，以及消除运输和储存强矿物酸。 公共卫生相关性：项目简介：在医药产品的合成中，使用催化膜反应器可以以更低的成本和更高的处理能力取代酸催化剂。

DESCRIPTION (provided by applicant): The commercial syntheses of many pharmaceutical active ingredients and intermediates require acid catalysts and the removal of water to drive reactions to completion. Typical reactions include esterifications of carboxylic acids with alcohols, Friedel-Crafts acylations and alkylations, Schiff base, acetal and ketal formation and nitrations of aromatic compounds. Although common mineral acids are typically employed as catalysts, they create issues with product purification, waste disposal, safety, the environment and homeland security. Compact Membrane Systems, Inc. (CMS) proposes to develop membrane reactors (MR) to enhance these processes and eliminate the problems created by existing acid catalysts. CMS proposes developing enhanced membrane reactors and demonstrating performance on relevant pharmaceutical reactants. CMS has obtained key industry experts to facilitate this program. In this program, CMS will fabricate the membrane reactors. The resultant MR will be used to run reactions of pharmaceutical interest such as the alkylation and nitration of aromatic compounds. Expectation is that the CMS membrane reactor will result in higher yields, faster reactions and less contaminated products relative to incumbent processes and will have a very long lifetime due to the perfluorinated nature of the polymer. Society will benefit due to the lower production costs for the products, option for synthesis at lower temperature to maximize API efficacy, minimization of waste products and elimination of the transport and storage of strong mineral acids. PUBLIC HEALTH RELEVANCE: Project Narrative The use of catalytic membrane reactors can replace acid catalysts in the synthesis of pharmaceutical products at lower cost and higher processing throughput.