Improved Dehydration Process for Pharmaceutical Synthesis II

药物合成脱水工艺的改进 II

• 批准号: 8323263
• 负责人: Andrew Feiring
• 金额: $ 48.2万
• 依托单位: COMPACT MEMBRANE SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8323263
• 关键词: Affect; Amination; Area; Automobile Driving; Biological Assay; Bromides; Chemicals; Chemistry; Commit; Consumption; Dehydration; Delaware; Development; Devices; Equilibrium; Evaluation; Excision; Feeds; Foxes; Heating; High temperature of physical object; Lead; Life; Membrane; Methods; NIH Program Announcements; Nature; Oxygen; Pharmacologic Substance; Phase; Physical condensation; Poison; Poisoning; Process; Production; Reaction; Reagent; Resistance; Savings; Sertraline; Side; Solvents; Suggestion; System; Technology; Temperature; Universities; Water; aprepitant; base; catalyst; celecoxib; cold temperature; cost; design; drug discovery; enzyme activity; improved; innovation; manufacturing process; molecular sieving; operation; planetary Atmosphere; professor; programs; reaction rate; research and development; sildenafil; success; tool; wasting; water environment

DESCRIPTION (provided by applicant): Compact Membrane Systems (CMS) proposes to develop a perfluoro membrane reactor technology that will provide a generally applicable tool for removing water and oxygen from pharmaceutical synthesis processes. This innovation aims to improve product quality and reduce manufacturing costs of pharmaceutical end products. Manufacturing cost reductions will be derived from improved product yields, increased reaction rates and reduced energy input requirements of the manufacturing process. Product quality improvements will be derived from the elimination of entrainers, azeotropic distillation, and drying reagents in the process as well as operation at lower temperatures and driving the reactant. The project has been expanded to include the removal of both oxygen and water in an effort to reduce side reactions and/or catalyst poisoning which should be of broad use in pharmaceutical synthesis. This membrane system has the capability to withstand process temperatures of 2200C endowing it with universal applicability in almost any organic-water environment for water separation in the synthesis of products such as sildenafil, celecoxib, sertraline, and aprepitant. Given the large water-organic compound separation factors achievable, the inertness of the membrane, and the ability to withstand harsh operating conditions, we believe we have an ideal system for reaction water and oxygen removal. The proposer will develop the membrane system and processes while the subcontractors will demonstrate Pd-catalyzed amination reactions. These reactions have revolutionized drug discovery and process chemistry in the past decade. The efficiency of Pd-catalyzed amination reactions can be negatively affected by impurities such as water. The Fox group at the University of Delaware and recently hired synthesis chemists at CMS (and consultants) will demonstrate the efficacy of the membrane process in Pd-catalyzed amination reactions in a study that will consist of: synthesis of the aryl bromide intermediate from the Astra Zeneca AR-A2 process; synthesis of the Pd-catalyzed amination product from the AR-A2 process; development of GC assays for the reactions; study of a control reaction without water/oxygen removal; and, study of amination with drying of the aryl bromide intermediate using the proprietary membrane. With success in Phase I, numerous industrial partners have either already spent over $150,000 on evaluation or committed to major evaluations in Phase II.

描述（由申请人提供）：紧凑膜系统公司（CMS）提议开发一种全氟膜反应器技术，该技术将提供一种普遍适用的工具，用于从药物合成过程中去除水和氧。这项创新旨在提高产品质量，降低制药终端产品的制造成本。生产成本的降低将源于产品产量的提高、反应速率的提高和生产过程中能源投入需求的减少。产品质量的提高将来自于在过程中消除夹带剂、共沸蒸馏和干燥试剂，以及在较低温度下操作和驱动反应物。该项目已扩大到包括氧气和水的去除，以努力减少副反应和/或催化剂中毒，这应该在药物合成中广泛使用。该膜系统能够承受2200C的工艺温度，因此几乎适用于任何有机水环境，用于合成西地那非、塞来昔布、舍曲林和阿瑞吡坦等产品的水分离。考虑到可实现的大水-有机化合物分离因子，膜的惰性，以及承受恶劣操作条件的能力，我们相信我们有一个理想的反应水和氧气去除系统。提案人将开发膜系统和工艺，而分包商将演示pd催化的胺化反应。在过去的十年中，这些反应已经彻底改变了药物发现和过程化学。钯催化的胺化反应的效率会受到水等杂质的负面影响。特拉华大学的Fox小组和最近聘请的CMS合成化学家（和顾问）将在一项研究中证明膜工艺在pd催化胺化反应中的功效，该研究将包括：从Astra Zeneca AR-A2工艺合成芳基溴中间体；AR-A2工艺合成pd催化胺化产物；气相色谱法测定反应的发展；不除水除氧对照反应的研究并研究了用该专有膜干燥芳基溴中间体的胺化反应。随着第一阶段的成功，许多工业合作伙伴要么已经在评估上花费了超过15万美元，要么承诺在第二阶段进行主要评估。