CLINICAL

核心B：临床 该核心评估并跟踪所有参与项目研究的参与者。它使用 建立临床和心理测量方案(包括统一的数据集评估) 此后每年获取临床、神经和行为数据，以仔细描述每个 参与者，包括痴呆症的诊断和分期。临床核心数据被所有核心和项目使用 探讨极轻度阿尔茨海默型痴呆(DAT)与健康脑的相关性 衰老。核心B：临床招募并保持足够的样本数量，以提供所需的参与者 这些项目。随着计划项目探索AD，对非痴呆症参与者的需求增加 痴呆症(临床前AD)发生前的大脑变化。核心课程将向学员推荐 核心E：成像以获得通用解剖方案，评估项目1(临床前AD)的参与者 预测卒中后痴呆“)卒中后1年，此后每年从所有参与者那里获取血液 在项目2(“脑脊液和血浆中AD的生物标志物”)和项目4(“序列”)中进行分析 生物标记物蛋白基因的变异和AD发病年龄“)，并让参与者参考脑脊液研究项目2 项目3(“DAT的标记物：控制性、变异性和个性”)，用于参与研究。 通过其成功的自愿尸检计划，Core为Core D：神经病理学提供了 神经病理诊断的尸检材料。核心B与核心C：生物统计密切合作，以确保 适当的数据管理。核心支持核心A：行政推动科学 所有研究人员之间的互动，以实现计划项目的整体目标。

Core B: Clinical This Core evaluates and follows all participants entered into the studies of the program project. It uses established clinical and psychometric protocols (including Uniform Data Set assessments) at entry and annually thereafter to obtain clinical, neurological, and behavioral data to carefully characterize each participant, including dementia diagnosis and staging. Clinical Core data are used by all Cores and Projects to explore the correlates of very mild dementia of the Alzheimer type (DAT) in comparison with healthy brain aging. Core B: Clinical recruits and maintains an adequate sample size to supply needed participants for the projects. There is an increased need for nondemented participants as the program project explores AD changes in the brain prior to the occurrence of dementia (preclinical AD). The Core will refer participants to Core E: Imaging to obtain the Common Anatomic Protocol, assess participants in Project 1 ("Preclinical AD predicts poststroke dementia") 1-year poststroke and annually thereafter, obtain blood from all participants for analysis in Project 2 ("Antecedent biomarkers of AD in CSF and plasma") and Project 4 ("Sequence variation in genes for biomarker proteins and age at onset of AD"), and refer participants to Project 2 for CSF collection and to Project 3 ("Markers for DAT: Control, variability, and personality") for study participation. Through its successful voluntary autopsy program the Core provides Core D: Neuropathology with autopsy material for neuropathologic diagnosis. Core B works closely with Core C: Biostatistics to ensure appropriate data management. The Core supports Core A: Administration in promoting scientific interactions among all investigators to accomplish the aims of the program project as a whole.