Clinical

核心支持成人儿童研究计划项目补助金通过招募，注册和纵向 随访入组时年龄为45-74岁的成年子女，父母患有和不患有阿尔茨海默型痴呆 （DAT）。年龄在45-64岁之间的ACS参与者将在入组时进行临床和心理评估， 年后（ACS参与者> 65岁每年）。核心是必不可少的，因为它仔细地提供 所有相关核心和项目的特征参与者。核心数据由核心人员输入 数据管理和生物统计核心（DMBC）。临床核心 每天与ACS PPG的几乎每个方面直接或间接交互。 核心的职能是： 1.招募、登记和维护ACS队列，以支持本申请中的项目。在最初的两年里 核心将招募60名ACS参与者，以补偿自然减员，并将总样本 约300名参与者平均分布在3个年龄范围：45-54岁，55-64岁和65-74岁。 在接下来的3年中，临床中心将每年招募约5名受试者，以维持 约300名活跃参与者的注册。 2.采用完善的临床和心理测量方法对ACS参与者进行全面评估 在入学时和每两年（参加者>65岁每年）。 3.在初始评估时从所有受试者中采集血液进行载脂蛋白E（apoE）基因分型， 提取的DNA和血浆的库（由ADRC的遗传学核心支持）。 4.协调ACS参与者参与生物标志物核心程序和所有项目： （项目1 -临床前AD中Ap积累的自然史。项目2 -前体CSF标志物 AD;项目3 -注意力控制的行为和神经标志物; AD的前因;项目4 - 先行神经影像学生物标志物。） 5.将所有核心数据与DMBC集成，并与PPG的所有组件进行协作交互。 6.通过保护ACS参与者的研究数据、监控 参与者在完成核心和项目协议时的负担，每年与他们分享 研究成果，并征求他们的投入到ACS的目标和业务。

The Core supports the Adult Children Study Program Project Grant by recruiting, enrolling and longitudinally following adult children, age 45-74 years at entry, of parents with and without dementia of the Alzheimer type (DAT). ACS participants age 45-64 will have clinical and psychometric assessments at entry and every 2 years thereafter (annually for ACS participants >65y). The Core is essential in that it supplies carefully characterized participants to all relevant Cores and Projects. Core data are entered by Core personnel into the database maintained by the Data Management and Biostatistics Core (DMBC). The Clinical Core interacts directly or indirectly on a daily basis with virtually every facet of the ACS PPG. The functions of the Core are to: 1. Recruit, enroll, and maintain the ACS cohort to support the Projects in this application. In the first 2 years of the grant, the Core will enroll 60 ACS participants to compensate for attrition and to bring the total sample to ~300 participants equally distributed across 3 age ranges: 45-54 years, 55-64 years, and 65-74 years. The following 3 years the Clinical Core will recruit an estimated 5 participants annually to maintain the registry of ~300 active participants. 2. Comprehensively assess the ACS participants with well-established clinical and psychometric instruments at entry and every two years (annually for participants >65 years of age). 3. Obtain blood at the initial assessment from all participants for apolipoprotein E (apoE) genotyping and banking of extracted DNA and plasma (supported by the Genetics Core of the ADRC). 4. Coordinate the participation of ACS participants in the procedures of the Biomarker Core and all Projects: (Project 1 - The natural history of Ap accumulation in preclinical AD. Project 2 - CSF markers of antecedent AD; Project 3 - Behavioral and Neural Markers of Attentional Control; Antecedents of AD; Project 4 - Antecedent Neuroimaging Biomarkers.) 5. Integrate all core data with the DMBC, and interact cooperatively with all components of the PPG. 6. Encourage the retention of ACS participants by safeguarding their research data, monitoring the participants' burden as they complete the protocols of the Cores and Projects, annually sharing with them research results, and soliciting their input into the aims and operations of the ACS.