CLINICAL

核心B：临床 该核心评估并跟踪所有参与该计划项目研究的参与者。它使用 在入组时建立临床和心理测量方案（包括统一数据集评估）， 此后每年获得临床，神经和行为数据，以仔细表征每个 参与者，包括痴呆诊断和分期。临床核心数据由所有核心和项目使用 探讨阿尔茨海默型极轻度痴呆（DAT）与健康大脑的相关性 衰老核心B：临床招募并维持足够的样本量，以提供所需的参与者， 项目。有一个非痴呆参与者的需求增加，因为该计划项目探讨AD 在痴呆（临床前AD）发生之前大脑的变化。核心小组将向与会者介绍 核心E：成像以获得通用解剖方案，评估项目1（“临床前AD”）的参与者 预测卒中后痴呆”）卒中后1年，此后每年从所有参与者中采集血液 用于项目2（“CSF和血浆中AD的先行生物标志物”）和项目4（“序列分析”）中的分析 生物标志物蛋白基因变异和AD发病时的年龄”），并将参与者推荐至CSF项目2 收集和项目3（“DAT标记：控制、变异性和个性”）用于研究参与。 通过其成功的自愿尸检计划，核心提供核心D：神经病理学， 神经病理学诊断尸检材料。核心B与核心C：生物统计学密切合作，以确保 适当的数据管理。核心部分支持核心部分A：行政部门促进科学 所有研究人员之间的互动，以实现整个计划项目的目标。

Core B: Clinical This Core evaluates and follows all participants entered into the studies of the program project. It uses established clinical and psychometric protocols (including Uniform Data Set assessments) at entry and annually thereafter to obtain clinical, neurological, and behavioral data to carefully characterize each participant, including dementia diagnosis and staging. Clinical Core data are used by all Cores and Projects to explore the correlates of very mild dementia of the Alzheimer type (DAT) in comparison with healthy brain aging. Core B: Clinical recruits and maintains an adequate sample size to supply needed participants for the projects. There is an increased need for nondemented participants as the program project explores AD changes in the brain prior to the occurrence of dementia (preclinical AD). The Core will refer participants to Core E: Imaging to obtain the Common Anatomic Protocol, assess participants in Project 1 ("Preclinical AD predicts poststroke dementia") 1-year poststroke and annually thereafter, obtain blood from all participants for analysis in Project 2 ("Antecedent biomarkers of AD in CSF and plasma") and Project 4 ("Sequence variation in genes for biomarker proteins and age at onset of AD"), and refer participants to Project 2 for CSF collection and to Project 3 ("Markers for DAT: Control, variability, and personality") for study participation. Through its successful voluntary autopsy program the Core provides Core D: Neuropathology with autopsy material for neuropathologic diagnosis. Core B works closely with Core C: Biostatistics to ensure appropriate data management. The Core supports Core A: Administration in promoting scientific interactions among all investigators to accomplish the aims of the program project as a whole.