DEVELOPMENT OF MEDIAL TEMPORAL LOBE FUNCTIONS

内侧颞叶功能的发育

• 批准号: 8357420
• 负责人: JOCELYNE H BACHEVALIER
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357420
• 关键词: Adolescent; Adult; Age; Animals; Area; Award; Brain; Data; Data Analyses; Development; Emotional; Fright; Funding; Grant; Hippocampus (Brain); Learning; Lesion; Medial; Mediating; Memory; Memory impairment; Monkeys; National Center for Research Resources; Neonatal; Positron-Emission Tomography; Primates; Principal Investigator; Protocols documentation; Research; Research Infrastructure; Resources; Short-Term Memory; Social Interaction; Source; System; Temporal Lobe; Testing; Training; United States National Institutes of Health; cost; infancy; memory process; memory recognition; relating to nervous system; social attachment

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project investigates (a) the development of hippocampal and perirhinal cortex functions in monkeys, (b) the long-term consequences of early insult to these brain areas on the maturation of memory processes and social bonds, and (c) the anatomical reorganization of other brain systems resulting from these early lesions as compared to adult lesions. In the current year, we have trained animals with neonatal hippocampal (Neo-H) lesions and their controls in a spatial memory foraging task, contextual memory tasks, working memory tasks, and fear learning and its modulation. Neo-H lesions resulted in robust deficits in spatial learning and working memory, although the ability to use contextual memory and to learn and modulate fear was not altered. We also validated a PET imaging protocol to assess prefrontal functioning in Neo-H animals. To pursue the characterization of animals with neonatal perirhinal lesions (Neo-PRh), we assessed object and spatial recognition memory, social interactions and emotional reactivity in Neo-PRh animals and their controls as they were adolescent. The data analyzed so far show that, unlike Neo-H lesions, Neo-PRh lesions impaired incidental recognition memory at all ages and all delays tested. However, the recognition memory deficit in Group Neo-PRh was less in magnitude than that found after Adult-PRh lesions, suggesting that the neural substrate mediating item-specific memory processes is more widespread in early infancy. Data obtained in the other tasks are being currently analyzed. Renewal of this project for another 5 years was submitted in March 2010 and awarded in December 2010.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目研究（a）猴子海马和嗅周皮质功能的发展，（B）这些脑区早期损伤对记忆过程和社会联系成熟的长期影响，以及（c）与成年损伤相比，这些早期损伤导致的其他脑系统的解剖学重组。 在本年度，我们训练了新生儿海马（Neo-H）病变的动物及其控制空间记忆觅食任务，上下文记忆任务，工作记忆任务，恐惧学习及其调制。新-H病变导致空间学习和工作记忆的强大赤字，虽然使用上下文记忆和学习和调节恐惧的能力没有改变。 我们还验证了PET成像方案来评估Neo-H动物的前额叶功能。为了进一步研究新生儿鼻周病变（Neo-PRh）动物的特征，我们评估了Neo-PRh动物及其青少年对照组的对象和空间识别记忆、社会互动和情绪反应。 到目前为止分析的数据表明，与Neo-H病变不同，Neo-PRh病变在所有年龄和所有延迟测试中都损害了偶然识别记忆。然而，识别记忆缺陷组新PRh的幅度小于成人PRh病变后发现的，这表明神经基质介导的项目特定的记忆过程是更广泛的婴儿早期。目前正在分析在其他任务中获得的数据。2010年3月提交了将该项目再延长5年的申请，并于2010年12月授予。