CONTINUITY OF THE LIMBIC CIRCUIT THROUGH THE BASAL GANGLIA

边缘回路通过基底神经节的连续性

• 批准号: 8172463
• 负责人: JOCELYNE H BACHEVALIER
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172463
• 关键词: 1 year old; 3 year old; Age; Amygdaloid structure; Basal Ganglia; Behavioral; Birth; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Data; Development; Diffuse; Funding; Grant; Growth; Habits; Hippocampus (Brain); Incentives; Injection of therapeutic agent; Institution; Learning; Macaca mulatta; Mental Depression; Mental Health; Modeling; Nodal; Obsessive-Compulsive Disorder; Pathway interactions; Prefrontal Cortex; Research; Research Personnel; Resources; Schizophrenia; Source; Stress; System; Temporal Lobe; Time; Tracer; United States National Institutes of Health; addiction; age group; base; clinically relevant; infancy; postnatal; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project characterizes convergence of specific prefrontal cortex (PFC) inputs with the amygdala and temporal cortex in distinct striatal regions and investigates how this system undergoes refinement and reorganization consistent with postnatal milestones of behavioral development. We have currently ordered two rhesus monkeys (3-year-old and 1-year-old) to begin this project in January 2010 using MRI-guided injections of neuroanatomical tracers into the amygdala. We will (a) examine anatomical changes in cortex, striatum, amygdala and hippocampal pathways at the age of birth, 2-4 mo., 6 mo., 1 yr., and 3 years; (b) characterize the specific organization of cortical, amygdala, and hippocampal inputs to the striatum, with a particular focus on the refinement of diffuse projections and the convergence of focal projections; (c) will compare the models of convergent nodal regions across all age groups. Data obtained from such anatomical studies are clinically relevant because infancy through young adulthood is that critical time in which incentive-based learning forms the basis for behavioral guiding rules and the development of habits. Consistent with rapid behavioral development, the prefrontal cortex, amygdala, hippocampus and striatum undergo maturation during postnatal development. This time of developmental growth is associated with vulnerability to stress and the emergence of mental health problems including schizophrenia, depression, obsessive-compulsive disorders and addictions.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的特点是特定的前额叶皮层（PFC）的输入与杏仁核和颞叶皮层在不同的纹状体区域的收敛，并调查这个系统如何进行完善和重组符合出生后的行为发展的里程碑。 我们目前已经订购了两只恒河猴（3岁和1岁），在2010年1月开始使用MRI引导的神经解剖示踪剂注射到杏仁核中的项目。我们将（a）检查出生时、2-4个月时皮质、纹状体、杏仁核和海马通路的解剖学变化，6个月，1年，3年;（B）描述皮质、杏仁核和海马体向纹状体输入的特定组织特征，特别关注弥散投射的细化和局灶性投射的会聚;（C）将比较所有年龄组的会聚节点区域模型。 从这些解剖学研究中获得的数据与临床相关，因为从婴儿期到青年期是基于激励的学习形成行为指导规则和习惯发展基础的关键时期。与快速的行为发育相一致，前额皮质、杏仁核、海马和纹状体在出生后发育期间经历成熟。 这段发育期与易受压力和出现精神健康问题有关，包括精神分裂症、抑郁症、强迫症和成瘾。