CONTINUITY OF THE LIMBIC CIRCUIT THROUGH THE BASAL GANGLIA

边缘回路通过基底神经节的连续性

• 批准号: 8357500
• 负责人: JOCELYNE H BACHEVALIER
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357500
• 关键词: 1 year old; 3 year old; Age; Amygdaloid structure; Basal Ganglia; Behavioral; Birth; Corpus striatum structure; Data; Development; Diffuse; Funding; Grant; Growth; Habits; Hippocampus (Brain); Incentives; Injection of therapeutic agent; Learning; Macaca mulatta; Magnetic Resonance Imaging; Mental Depression; Mental Health; Modeling; National Center for Research Resources; Nodal; Obsessive-Compulsive Disorder; Pathway interactions; Prefrontal Cortex; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Schizophrenia; Source; Stress; System; Temporal Lobe; Time; Tracer; United States National Institutes of Health; addiction; age group; base; clinically relevant; cost; infancy; postnatal; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project characterizes convergence of specific prefrontal cortex (PFC) inputs with the amygdala and temporal cortex in distinct striatal regions and investigates how this system undergoes refinement and reorganization consistent with postnatal milestones of behavioral development. We have currently ordered two rhesus monkeys (3-year-old and 1-year-old) to begin this project in January 2010 using MRI-guided injections of neuroanatomical tracers into the amygdala. We will (a) examine anatomical changes in cortex, striatum, amygdala and hippocampal pathways at the age of birth, 2-4 mo., 6 mo., 1 yr., and 3 years; (b) characterize the specific organization of cortical, amygdala, and hippocampal inputs to the striatum, with a particular focus on the refinement of diffuse projections and the convergence of focal projections; (c) will compare the models of convergent nodal regions across all age groups. Data obtained from such anatomical studies are clinically relevant because infancy through young adulthood is that critical time in which incentive-based learning forms the basis for behavioral guiding rules and the development of habits. Consistent with rapid behavioral development, the prefrontal cortex, amygdala, hippocampus and striatum undergo maturation during postnatal development. This time of developmental growth is associated with vulnerability to stress and the emergence of mental health problems including schizophrenia, depression, obsessive-compulsive disorders and addictions.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的特点是特定的前额叶皮层（PFC）的输入与杏仁核和颞叶皮层在不同的纹状体区域的收敛，并调查这个系统如何进行完善和重组符合出生后的行为发展的里程碑。 我们目前已经订购了两只恒河猴（3岁和1岁），在2010年1月开始使用MRI引导的神经解剖示踪剂注射到杏仁核中的项目。我们将（a）检查出生时、2-4个月时皮质、纹状体、杏仁核和海马通路的解剖学变化，6个月，1年，3年;（B）描述皮层、杏仁核和海马体对纹状体的输入的具体组织，特别关注弥散投射的细化和局灶投射的会聚;（c）将比较所有年龄组的会聚节点区域模型。 从这些解剖学研究中获得的数据与临床相关，因为从婴儿期到青年期是基于激励的学习形成行为指导规则和习惯发展基础的关键时期。与快速的行为发育相一致，前额皮质、杏仁核、海马和纹状体在出生后发育期间经历成熟。 这段发育期与易受压力和出现精神健康问题有关，包括精神分裂症、抑郁症、强迫症和成瘾。